Clinical and radiological features of invasive pulmonary aspergillosis in transplant recipients and neutropenic patients

S.Y. Park, S.‐H. Kim, S.‐H. Choi, H. Sung, M.‐N. Kim, J.H. Woo, Y.S. Kim, S.‐K. Park, J.‐H. Lee, K.‐H. Lee, S.‐G. Lee, D.J. Han, S.‐O. Lee. Clinical and radiological features of invasive pulmonary aspergillosis in transplant recipients and neutropenic patients.
Transpl Infect Dis 2010: 12: 309–315....

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Veröffentlicht in:Transplant infectious disease 2010-08, Vol.12 (4), p.309-315
Hauptverfasser: Park, S.Y., Kim, S.-H., Choi, S.-H., Sung, H., Kim, M.-N., Woo, J.H., Kim, Y.S., Park, S.-K., Lee, J.-H., Lee, K.-H., Lee, S.-G., Han, D.J., Lee, S.-O.
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container_end_page 315
container_issue 4
container_start_page 309
container_title Transplant infectious disease
container_volume 12
creator Park, S.Y.
Kim, S.-H.
Choi, S.-H.
Sung, H.
Kim, M.-N.
Woo, J.H.
Kim, Y.S.
Park, S.-K.
Lee, J.-H.
Lee, K.-H.
Lee, S.-G.
Han, D.J.
Lee, S.-O.
description S.Y. Park, S.‐H. Kim, S.‐H. Choi, H. Sung, M.‐N. Kim, J.H. Woo, Y.S. Kim, S.‐K. Park, J.‐H. Lee, K.‐H. Lee, S.‐G. Lee, D.J. Han, S.‐O. Lee. Clinical and radiological features of invasive pulmonary aspergillosis in transplant recipients and neutropenic patients.
Transpl Infect Dis 2010: 12: 309–315. All rights reserved : Invasive pulmonary aspergillosis (IPA) is an important cause of mortality in transplant recipients and in patients with neutropenia. Although IPA has been studied extensively in neutropenic patients, there are limited data on IPA in recipients of solid organ transplants (SOTs). We compared the clinical features and radiologic findings of 27 SOT recipients with IPA with those of 35 neutropenic patients with IPA. The SOT recipients were more likely than neutropenic patients to show peribronchial consolidation (31% vs. 7%; P=0.03) or ground‐glass opacity (38% vs. 7%; P=0.007) and less likely to have fever (22% vs. 80%; P
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Transpl Infect Dis 2010: 12: 309–315. All rights reserved : Invasive pulmonary aspergillosis (IPA) is an important cause of mortality in transplant recipients and in patients with neutropenia. Although IPA has been studied extensively in neutropenic patients, there are limited data on IPA in recipients of solid organ transplants (SOTs). We compared the clinical features and radiologic findings of 27 SOT recipients with IPA with those of 35 neutropenic patients with IPA. The SOT recipients were more likely than neutropenic patients to show peribronchial consolidation (31% vs. 7%; P=0.03) or ground‐glass opacity (38% vs. 7%; P=0.007) and less likely to have fever (22% vs. 80%; P&lt;0.001), macro‐nodules (35% vs. 67%; P=0.02), mass‐like consolidation (27% vs. 67%; P=0.004), halo signs (8% vs. 56%; P&lt;0.001), or air‐crescent signs (0% vs. 22%; P=0.01).</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/j.1399-3062.2010.00499.x</identifier><identifier>PMID: 20202177</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aspergillosis ; Aspergillus ; Child ; Female ; Humans ; Immunocompromised Host ; invasive pulmonary aspergillosis ; Invasive Pulmonary Aspergillosis - diagnostic imaging ; Invasive Pulmonary Aspergillosis - mortality ; Invasive Pulmonary Aspergillosis - physiopathology ; Lung - diagnostic imaging ; Lung transplantation ; Male ; Neutropenia ; Neutropenia - complications ; Organ Transplantation - adverse effects ; Parks ; Republic of Korea ; solid organ transplantation ; Tomography, X-Ray Computed - methods ; Young Adult</subject><ispartof>Transplant infectious disease, 2010-08, Vol.12 (4), p.309-315</ispartof><rights>2010 John Wiley &amp; Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4549-b3ba39b862788c83db91faa1ab08dc9fe44d27a84b79e41a76dfc8efc5a1343c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-3062.2010.00499.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-3062.2010.00499.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20202177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, S.Y.</creatorcontrib><creatorcontrib>Kim, S.-H.</creatorcontrib><creatorcontrib>Choi, S.-H.</creatorcontrib><creatorcontrib>Sung, H.</creatorcontrib><creatorcontrib>Kim, M.-N.</creatorcontrib><creatorcontrib>Woo, J.H.</creatorcontrib><creatorcontrib>Kim, Y.S.</creatorcontrib><creatorcontrib>Park, S.-K.</creatorcontrib><creatorcontrib>Lee, J.-H.</creatorcontrib><creatorcontrib>Lee, K.-H.</creatorcontrib><creatorcontrib>Lee, S.-G.</creatorcontrib><creatorcontrib>Han, D.J.</creatorcontrib><creatorcontrib>Lee, S.-O.</creatorcontrib><title>Clinical and radiological features of invasive pulmonary aspergillosis in transplant recipients and neutropenic patients</title><title>Transplant infectious disease</title><addtitle>Transpl Infect Dis</addtitle><description>S.Y. Park, S.‐H. Kim, S.‐H. Choi, H. Sung, M.‐N. Kim, J.H. Woo, Y.S. Kim, S.‐K. Park, J.‐H. Lee, K.‐H. Lee, S.‐G. Lee, D.J. Han, S.‐O. Lee. Clinical and radiological features of invasive pulmonary aspergillosis in transplant recipients and neutropenic patients.
Transpl Infect Dis 2010: 12: 309–315. All rights reserved : Invasive pulmonary aspergillosis (IPA) is an important cause of mortality in transplant recipients and in patients with neutropenia. Although IPA has been studied extensively in neutropenic patients, there are limited data on IPA in recipients of solid organ transplants (SOTs). We compared the clinical features and radiologic findings of 27 SOT recipients with IPA with those of 35 neutropenic patients with IPA. The SOT recipients were more likely than neutropenic patients to show peribronchial consolidation (31% vs. 7%; P=0.03) or ground‐glass opacity (38% vs. 7%; P=0.007) and less likely to have fever (22% vs. 80%; P&lt;0.001), macro‐nodules (35% vs. 67%; P=0.02), mass‐like consolidation (27% vs. 67%; P=0.004), halo signs (8% vs. 56%; P&lt;0.001), or air‐crescent signs (0% vs. 22%; P=0.01).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aspergillosis</subject><subject>Aspergillus</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>invasive pulmonary aspergillosis</subject><subject>Invasive Pulmonary Aspergillosis - diagnostic imaging</subject><subject>Invasive Pulmonary Aspergillosis - mortality</subject><subject>Invasive Pulmonary Aspergillosis - physiopathology</subject><subject>Lung - diagnostic imaging</subject><subject>Lung transplantation</subject><subject>Male</subject><subject>Neutropenia</subject><subject>Neutropenia - complications</subject><subject>Organ Transplantation - adverse effects</subject><subject>Parks</subject><subject>Republic of Korea</subject><subject>solid organ transplantation</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Young Adult</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0Eoh_wF5BvnLK1Y29sS1zQQj-kFqqqwNGaOJPKizcJdlK2_77ebNkr9sGjmecdj-YlhHK24PmcrRdcGFMIVpWLkuUsY9KYxfYVOT4UXs-xLspSiSNyktKaMa6MNG_JUcny5Uodk-0q-M47CBS6hkZofB_6hznRIoxTxET7lvruEZJ_RDpMYdN3EJ8opAHjgw-hTz5lgI4RujQE6EYa0fnBYzemuW2H0xj7AfNHdIBxLrwjb1oICd-_vKfkx_nX-9Vlcf394mr1-bpwcilNUYsahKl1VSqtnRZNbXgLwKFmunGmRSmbUoGWtTIoOaiqaZ3G1i2BCymcOCUf932H2P-ZMI1245PDkOfEfkpWC1NVQlfyv6SS2qg8hsrkhxdyqjfY2CH6TV6J_bfWDHzaA399wKdDnTO7s8-u7c4lu3PJ7uyzs312a--vvuQgy4u93KcRtwc5xN-2UkIt7a9vF_bnbanubi7PrRTP6tegXg</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Park, S.Y.</creator><creator>Kim, S.-H.</creator><creator>Choi, S.-H.</creator><creator>Sung, H.</creator><creator>Kim, M.-N.</creator><creator>Woo, J.H.</creator><creator>Kim, Y.S.</creator><creator>Park, S.-K.</creator><creator>Lee, J.-H.</creator><creator>Lee, K.-H.</creator><creator>Lee, S.-G.</creator><creator>Han, D.J.</creator><creator>Lee, S.-O.</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>M7N</scope></search><sort><creationdate>201008</creationdate><title>Clinical and radiological features of invasive pulmonary aspergillosis in transplant recipients and neutropenic patients</title><author>Park, S.Y. ; Kim, S.-H. ; Choi, S.-H. ; Sung, H. ; Kim, M.-N. ; Woo, J.H. ; Kim, Y.S. ; Park, S.-K. ; Lee, J.-H. ; Lee, K.-H. ; Lee, S.-G. ; Han, D.J. ; Lee, S.-O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4549-b3ba39b862788c83db91faa1ab08dc9fe44d27a84b79e41a76dfc8efc5a1343c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aspergillosis</topic><topic>Aspergillus</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>invasive pulmonary aspergillosis</topic><topic>Invasive Pulmonary Aspergillosis - diagnostic imaging</topic><topic>Invasive Pulmonary Aspergillosis - mortality</topic><topic>Invasive Pulmonary Aspergillosis - physiopathology</topic><topic>Lung - diagnostic imaging</topic><topic>Lung transplantation</topic><topic>Male</topic><topic>Neutropenia</topic><topic>Neutropenia - complications</topic><topic>Organ Transplantation - adverse effects</topic><topic>Parks</topic><topic>Republic of Korea</topic><topic>solid organ transplantation</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, S.Y.</creatorcontrib><creatorcontrib>Kim, S.-H.</creatorcontrib><creatorcontrib>Choi, S.-H.</creatorcontrib><creatorcontrib>Sung, H.</creatorcontrib><creatorcontrib>Kim, M.-N.</creatorcontrib><creatorcontrib>Woo, J.H.</creatorcontrib><creatorcontrib>Kim, Y.S.</creatorcontrib><creatorcontrib>Park, S.-K.</creatorcontrib><creatorcontrib>Lee, J.-H.</creatorcontrib><creatorcontrib>Lee, K.-H.</creatorcontrib><creatorcontrib>Lee, S.-G.</creatorcontrib><creatorcontrib>Han, D.J.</creatorcontrib><creatorcontrib>Lee, S.-O.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, S.Y.</au><au>Kim, S.-H.</au><au>Choi, S.-H.</au><au>Sung, H.</au><au>Kim, M.-N.</au><au>Woo, J.H.</au><au>Kim, Y.S.</au><au>Park, S.-K.</au><au>Lee, J.-H.</au><au>Lee, K.-H.</au><au>Lee, S.-G.</au><au>Han, D.J.</au><au>Lee, S.-O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and radiological features of invasive pulmonary aspergillosis in transplant recipients and neutropenic patients</atitle><jtitle>Transplant infectious disease</jtitle><addtitle>Transpl Infect Dis</addtitle><date>2010-08</date><risdate>2010</risdate><volume>12</volume><issue>4</issue><spage>309</spage><epage>315</epage><pages>309-315</pages><issn>1398-2273</issn><eissn>1399-3062</eissn><abstract>S.Y. Park, S.‐H. Kim, S.‐H. Choi, H. Sung, M.‐N. Kim, J.H. Woo, Y.S. Kim, S.‐K. Park, J.‐H. Lee, K.‐H. Lee, S.‐G. Lee, D.J. Han, S.‐O. Lee. Clinical and radiological features of invasive pulmonary aspergillosis in transplant recipients and neutropenic patients.
Transpl Infect Dis 2010: 12: 309–315. All rights reserved : Invasive pulmonary aspergillosis (IPA) is an important cause of mortality in transplant recipients and in patients with neutropenia. Although IPA has been studied extensively in neutropenic patients, there are limited data on IPA in recipients of solid organ transplants (SOTs). We compared the clinical features and radiologic findings of 27 SOT recipients with IPA with those of 35 neutropenic patients with IPA. The SOT recipients were more likely than neutropenic patients to show peribronchial consolidation (31% vs. 7%; P=0.03) or ground‐glass opacity (38% vs. 7%; P=0.007) and less likely to have fever (22% vs. 80%; P&lt;0.001), macro‐nodules (35% vs. 67%; P=0.02), mass‐like consolidation (27% vs. 67%; P=0.004), halo signs (8% vs. 56%; P&lt;0.001), or air‐crescent signs (0% vs. 22%; P=0.01).</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>20202177</pmid><doi>10.1111/j.1399-3062.2010.00499.x</doi><tpages>7</tpages></addata></record>
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subjects Adolescent
Adult
Aged
Aged, 80 and over
Aspergillosis
Aspergillus
Child
Female
Humans
Immunocompromised Host
invasive pulmonary aspergillosis
Invasive Pulmonary Aspergillosis - diagnostic imaging
Invasive Pulmonary Aspergillosis - mortality
Invasive Pulmonary Aspergillosis - physiopathology
Lung - diagnostic imaging
Lung transplantation
Male
Neutropenia
Neutropenia - complications
Organ Transplantation - adverse effects
Parks
Republic of Korea
solid organ transplantation
Tomography, X-Ray Computed - methods
Young Adult
title Clinical and radiological features of invasive pulmonary aspergillosis in transplant recipients and neutropenic patients
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