DNA hydrolysis by monoclonal autoantibody BV 04-01

Monoclonal anti-DNA autoantibody BV 04-01 catalyzed hydrolysis of DNA in the presence of Mg2+. Catalysis was associated with BV 04-01 IgG, Fab, and single-chain-antibody (SCA) proteins. Cleavage of both ss and dsDNA was observed with efficient hydrolysis of the C-rich region of A7C7ATATAGCGCGT2, as...

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Veröffentlicht in:	Applied biochemistry and biotechnology 2000-01, Vol.83 (1-3), p.95-105
Hauptverfasser:	Rodkey, L S, Gololobov, G, Rumbley, C A, Rumbley, J, Schourov, D V, Makarevich, O I, Gabibov, A G, Voss, Jr, E W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Antinuclear - chemistry Antibodies, Antinuclear - genetics Antibodies, Antinuclear - metabolism Antibodies, Catalytic - chemistry Antibodies, Catalytic - genetics Antibodies, Catalytic - metabolism Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Autoantibodies Base Sequence Binding Sites Biochemistry Catalysis Catalytic activity Chains Coordination compounds Deoxyribonucleic acid DNA DNA - chemistry DNA - immunology DNA - metabolism Enzymes Hydrolysis Immunoglobulin G In Vitro Techniques Kinetics Magnesium Mice Models, Molecular Mutation Nucleotide sequence Protein Conformation Proteins Studies
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