Nocodazole induces mitotic cell death with apoptotic-like features in Saccharomyces cerevisiae

We investigated the fate of budding yeast treated with nocodazole, a microtubule-depolymerizing drug. Cells died after mitotic arrest while staying in mitosis, suggesting that mitotic cell death, but not mitotic slippage, mainly occurs in nocodazole-treated cells. Nocodazole-treated cells showed fea...

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Veröffentlicht in:	FEBS letters 2010-06, Vol.584 (11), p.2387-2392
Hauptverfasser:	Endo, Kingo, Mizuguchi, Mayumi, Harata, Aoi, Itoh, Go, Tanaka, Kozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase-Promoting Complex-Cyclosome APC/C Apoptosis Budding yeast Cell Death - drug effects Cell Nucleus - metabolism GFP green fluorescent protein Humans Microtubules - metabolism Mitosis - drug effects Mitotic arrest Mitotic cell death Nocodazole Nocodazole - pharmacology propidium iodide reactive oxygen species ROS SAC Saccharomyces cerevisiae Saccharomyces cerevisiae - metabolism spindle assembly checkpoint terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling TUNEL Ubiquitin-Protein Ligase Complexes - metabolism
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