Effects of a Prolonged Vitamin E Deficiency in the Rat
Rats fed a vitamin E-deficient diet containing 10% “stripped” corn oil had reduced growth rate and elevated platelet count by 12 weeks of age, and a normocytic anemia with elevated reticulocytes by 16 weeks of age. After 5 months, rats became emaciated and developed kyphoscoliosis. Some rats develop...
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| Veröffentlicht in: | The Journal of nutrition 1977-07, Vol.107 (7), p.1200-1208 |
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| container_title | The Journal of nutrition |
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| creator | Machlin, L.J. Filipski, R. Horn, L.R. Brin, M. Nelson, J. |
| description | Rats fed a vitamin E-deficient diet containing 10% “stripped” corn oil had reduced growth rate and elevated platelet count by 12 weeks of age, and a normocytic anemia with elevated reticulocytes by 16 weeks of age. After 5 months, rats became emaciated and developed kyphoscoliosis. Some rats developed skin ulcers and tremors, and mortality was high. Neuromuscular lesions included a chronic necrotizing myopathy and localized axonal dystrophy. There was also a selective activation of lysosomes in the central nervous system microcirculation. Liver ascorbic acid of deficient rats was the same as in those receiving vitamin E. Urinary excretion of p-hydroxyphenylpyruvate after a tyrosine load was also the same in deficient and control rats. It was concluded that neither vitamin C synthesis or utilization was affected in the E-deficient rats. |
| doi_str_mv | 10.1093/jn/107.7.1200 |
| format | Article |
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After 5 months, rats became emaciated and developed kyphoscoliosis. Some rats developed skin ulcers and tremors, and mortality was high. Neuromuscular lesions included a chronic necrotizing myopathy and localized axonal dystrophy. There was also a selective activation of lysosomes in the central nervous system microcirculation. Liver ascorbic acid of deficient rats was the same as in those receiving vitamin E. Urinary excretion of p-hydroxyphenylpyruvate after a tyrosine load was also the same in deficient and control rats. It was concluded that neither vitamin C synthesis or utilization was affected in the E-deficient rats.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/107.7.1200</identifier><identifier>PMID: 874563</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age Factors ; anemia ; Anemia - etiology ; Animals ; Ascorbic Acid - metabolism ; ascorbic acid synthesis ; Female ; kyphoscoliosis ; Kyphosis - etiology ; Male ; Muscular Diseases - etiology ; myopathy ; Necrosis ; Nervous System Diseases - etiology ; neuropathy ; Rats - metabolism ; Scoliosis - etiology ; Skin Ulcer - etiology ; thrombocythemia ; Thrombocytosis - complications ; vitamin E deficiency ; Vitamin E Deficiency - complications ; Vitamin E Deficiency - metabolism ; Vitamin E Deficiency - pathology</subject><ispartof>The Journal of nutrition, 1977-07, Vol.107 (7), p.1200-1208</ispartof><rights>1977 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-694d7757e5c5ddd23593fb2afeff09eccb49a81eebb04d5f49101b2880e568953</citedby><cites>FETCH-LOGICAL-c424t-694d7757e5c5ddd23593fb2afeff09eccb49a81eebb04d5f49101b2880e568953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/874563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machlin, L.J.</creatorcontrib><creatorcontrib>Filipski, R.</creatorcontrib><creatorcontrib>Horn, L.R.</creatorcontrib><creatorcontrib>Brin, M.</creatorcontrib><creatorcontrib>Nelson, J.</creatorcontrib><title>Effects of a Prolonged Vitamin E Deficiency in the Rat</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Rats fed a vitamin E-deficient diet containing 10% “stripped” corn oil had reduced growth rate and elevated platelet count by 12 weeks of age, and a normocytic anemia with elevated reticulocytes by 16 weeks of age. 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It was concluded that neither vitamin C synthesis or utilization was affected in the E-deficient rats.</description><subject>Age Factors</subject><subject>anemia</subject><subject>Anemia - etiology</subject><subject>Animals</subject><subject>Ascorbic Acid - metabolism</subject><subject>ascorbic acid synthesis</subject><subject>Female</subject><subject>kyphoscoliosis</subject><subject>Kyphosis - etiology</subject><subject>Male</subject><subject>Muscular Diseases - etiology</subject><subject>myopathy</subject><subject>Necrosis</subject><subject>Nervous System Diseases - etiology</subject><subject>neuropathy</subject><subject>Rats - metabolism</subject><subject>Scoliosis - etiology</subject><subject>Skin Ulcer - etiology</subject><subject>thrombocythemia</subject><subject>Thrombocytosis - complications</subject><subject>vitamin E deficiency</subject><subject>Vitamin E Deficiency - complications</subject><subject>Vitamin E Deficiency - metabolism</subject><subject>Vitamin E Deficiency - pathology</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS3EqxSW7BDKil3acWLH8RKV8pCQQLy2lmOPwVWbgJ0i9e8xBLFjdTWaozuaQ8gxhQkFWU4X7ZSCmIgJLQC2yIhyRvOKAmyTEUBR5CWtqn1yEOMCACiT9R7ZrQXjVTki1dw5NH3MOpfp7D50y659RZu9-F6vfJvNswt03nhszSZLc_-G2YPuD8mO08uIR785Js-X86fZdX57d3UzO7_NDStYn1eSWSG4QG64tbYouSxdU2iHzoFEYxomdU0RmwaY5Y5JCrQp6hqQV7Xk5ZicDb3voftYY-zVykeDy6VusVtHVZeyolzQBOYDaEIXY0Cn3oNf6bBRFNS3JrVoUwol1LemxJ_8Fq-bFdo_evCS1qfD2ulO6dfgo3p-pFKI5LMQiRgTMQCYvv_0GFT8kYTWh-RT2c7_c_kLXJF8kQ</recordid><startdate>197707</startdate><enddate>197707</enddate><creator>Machlin, L.J.</creator><creator>Filipski, R.</creator><creator>Horn, L.R.</creator><creator>Brin, M.</creator><creator>Nelson, J.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197707</creationdate><title>Effects of a Prolonged Vitamin E Deficiency in the Rat</title><author>Machlin, L.J. ; Filipski, R. ; Horn, L.R. ; Brin, M. ; Nelson, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-694d7757e5c5ddd23593fb2afeff09eccb49a81eebb04d5f49101b2880e568953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Age Factors</topic><topic>anemia</topic><topic>Anemia - etiology</topic><topic>Animals</topic><topic>Ascorbic Acid - metabolism</topic><topic>ascorbic acid synthesis</topic><topic>Female</topic><topic>kyphoscoliosis</topic><topic>Kyphosis - etiology</topic><topic>Male</topic><topic>Muscular Diseases - etiology</topic><topic>myopathy</topic><topic>Necrosis</topic><topic>Nervous System Diseases - etiology</topic><topic>neuropathy</topic><topic>Rats - metabolism</topic><topic>Scoliosis - etiology</topic><topic>Skin Ulcer - etiology</topic><topic>thrombocythemia</topic><topic>Thrombocytosis - complications</topic><topic>vitamin E deficiency</topic><topic>Vitamin E Deficiency - complications</topic><topic>Vitamin E Deficiency - metabolism</topic><topic>Vitamin E Deficiency - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Machlin, L.J.</creatorcontrib><creatorcontrib>Filipski, R.</creatorcontrib><creatorcontrib>Horn, L.R.</creatorcontrib><creatorcontrib>Brin, M.</creatorcontrib><creatorcontrib>Nelson, J.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machlin, L.J.</au><au>Filipski, R.</au><au>Horn, L.R.</au><au>Brin, M.</au><au>Nelson, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a Prolonged Vitamin E Deficiency in the Rat</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1977-07</date><risdate>1977</risdate><volume>107</volume><issue>7</issue><spage>1200</spage><epage>1208</epage><pages>1200-1208</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Rats fed a vitamin E-deficient diet containing 10% “stripped” corn oil had reduced growth rate and elevated platelet count by 12 weeks of age, and a normocytic anemia with elevated reticulocytes by 16 weeks of age. After 5 months, rats became emaciated and developed kyphoscoliosis. Some rats developed skin ulcers and tremors, and mortality was high. Neuromuscular lesions included a chronic necrotizing myopathy and localized axonal dystrophy. There was also a selective activation of lysosomes in the central nervous system microcirculation. Liver ascorbic acid of deficient rats was the same as in those receiving vitamin E. Urinary excretion of p-hydroxyphenylpyruvate after a tyrosine load was also the same in deficient and control rats. It was concluded that neither vitamin C synthesis or utilization was affected in the E-deficient rats.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>874563</pmid><doi>10.1093/jn/107.7.1200</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 1977-07, Vol.107 (7), p.1200-1208 |
| issn | 0022-3166 1541-6100 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Age Factors anemia Anemia - etiology Animals Ascorbic Acid - metabolism ascorbic acid synthesis Female kyphoscoliosis Kyphosis - etiology Male Muscular Diseases - etiology myopathy Necrosis Nervous System Diseases - etiology neuropathy Rats - metabolism Scoliosis - etiology Skin Ulcer - etiology thrombocythemia Thrombocytosis - complications vitamin E deficiency Vitamin E Deficiency - complications Vitamin E Deficiency - metabolism Vitamin E Deficiency - pathology |
| title | Effects of a Prolonged Vitamin E Deficiency in the Rat |
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