Chronic Wound Fluid Suppresses Proliferation of Dermal Fibroblasts Through a Ras-Mediated Signaling Pathway

Wound fluid collected from chronic venous leg ulcers (chronic wound fluid (CWF)) has been shown to inhibit the growth of dermal fibroblasts by interfering with cell-cycle progression from G1 into S phase. Specifically, CWF was shown to downregulate the levels of hyperphosphorylated retinoblastoma tu...

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