A novel mechanism for the modulation of the Ras-effector interaction by small molecules

When proteins require different conformations for their biological function, all these functional states have to coexist simultaneously in solution. However, the corresponding Gibbs free energy differences are usually rather high and thus the conformation with lowest energy predominates in solution...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical and biophysical research communications 2005-08, Vol.334 (2), p.709-713
Hauptverfasser:	Spoerner, Michael, Graf, Thorsten, König, Burkhard, Kalbitzer, Hans Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	31P NMR Anti-tumor therapy Conformational equilibrium Humans Magnetic Resonance Spectroscopy Molecular Weight Phosphorus Radioisotopes Protein Conformation Ras ras Proteins - analysis ras Proteins - chemistry Solutions Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!