Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38

Activating mutations in the K- ras gene are genetic alterations frequently found in human carcinomas, particularly in pancreatic adenocarcinomas. Mutation of the K- ras gene is thought to be an early and important event in pancreatic tumor initiation, but the precise role of the mutant K-Ras protein...

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