JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53

The extracellular matrix regulates many cellular processes, including survival, and alterations in the matrix or in matrix survival signals can trigger apoptosis. Previously, we showed that an altered fibronectin matrix triggers apoptosis in primary cells via a novel pathway regulated by transcripti...

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Veröffentlicht in:	The Journal of biological chemistry 2005-05, Vol.280 (20), p.19992-19999
Hauptverfasser:	Tafolla, Elizabeth, Wang, Shaohui, Wong, Benita, Leong, Jeffrey, Kapila, Yvonne L
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Base Sequence Cells, Cultured Extracellular Matrix - metabolism Feedback Fibronectins - metabolism Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Humans Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - genetics Mitogen-Activated Protein Kinase 8 - metabolism Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Mitogen-Activated Protein Kinase 9 - genetics Mitogen-Activated Protein Kinase 9 - metabolism Models, Biological Oligodeoxyribonucleotides, Antisense - genetics Phosphorylation Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Signal Transduction Tumor Suppressor Protein p53 - metabolism
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