Ras pathway signaling on endomembranes
Until recently, the plasma membrane has been considered to be a unique platform from which emanate the signaling events regulating or regulated by Ras and its close relatives. For the past few years, the role of endosomes derived from the plasma membrane as platforms for Ras/mitogen-activated protei...
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| Veröffentlicht in: | Current opinion in cell biology 2003-04, Vol.15 (2), p.136-142 |
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| container_title | Current opinion in cell biology |
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| creator | Bivona, Trever G Philips, Mark R |
| description | Until recently, the plasma membrane has been considered to be a unique platform from which emanate the signaling events regulating or regulated by Ras and its close relatives. For the past few years, the role of endosomes derived from the plasma membrane as platforms for Ras/mitogen-activated protein kinase signaling has been appreciated. More recently, the cytoplasmic face of the Golgi apparatus and endoplasmic reticulum have been shown to host Ras signaling. The biological implications of compartmentalized signaling are only beginning to emerge. |
| doi_str_mv | 10.1016/S0955-0674(03)00016-4 |
| format | Article |
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The biological implications of compartmentalized signaling are only beginning to emerge.</description><identifier>ISSN: 0955-0674</identifier><identifier>EISSN: 1879-0410</identifier><identifier>DOI: 10.1016/S0955-0674(03)00016-4</identifier><identifier>PMID: 12648668</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cell Compartmentation - physiology ; Endoplasmic Reticulum - physiology ; Endosomes - metabolism ; Eukaryotic Cells - metabolism ; Golgi Apparatus - physiology ; Humans ; Intracellular Membranes - metabolism ; MAP Kinase Signaling System - physiology ; ras Proteins - metabolism</subject><ispartof>Current opinion in cell biology, 2003-04, Vol.15 (2), p.136-142</ispartof><rights>2003 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-7dff569e1ae61f996ad0ae09feb3d001a93f9a2d2e690b9e355b0e19afe0bb723</citedby><cites>FETCH-LOGICAL-c393t-7dff569e1ae61f996ad0ae09feb3d001a93f9a2d2e690b9e355b0e19afe0bb723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0955067403000164$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12648668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bivona, Trever G</creatorcontrib><creatorcontrib>Philips, Mark R</creatorcontrib><title>Ras pathway signaling on endomembranes</title><title>Current opinion in cell biology</title><addtitle>Curr Opin Cell Biol</addtitle><description>Until recently, the plasma membrane has been considered to be a unique platform from which emanate the signaling events regulating or regulated by Ras and its close relatives. For the past few years, the role of endosomes derived from the plasma membrane as platforms for Ras/mitogen-activated protein kinase signaling has been appreciated. More recently, the cytoplasmic face of the Golgi apparatus and endoplasmic reticulum have been shown to host Ras signaling. The biological implications of compartmentalized signaling are only beginning to emerge.</description><subject>Animals</subject><subject>Cell Compartmentation - physiology</subject><subject>Endoplasmic Reticulum - physiology</subject><subject>Endosomes - metabolism</subject><subject>Eukaryotic Cells - metabolism</subject><subject>Golgi Apparatus - physiology</subject><subject>Humans</subject><subject>Intracellular Membranes - metabolism</subject><subject>MAP Kinase Signaling System - physiology</subject><subject>ras Proteins - metabolism</subject><issn>0955-0674</issn><issn>1879-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaCsCiwC4zhx4hVCFS-pEhKPteXE42KUR7FTUP8e9yHYwWqk0blzR4eQYwoXFCi_fAaRZTHwPD0Ddg4QdnG6Q4a0yEUMKYVdMvxBBuTA-_cAcUjEPhnQhKcF58WQjJ-Uj-aqf_tSy8jbWatq286iro2w1V2DTelUi_6Q7BlVezzazhF5vb15mdzH08e7h8n1NK6YYH2ca2MyLpAq5NQIwZUGhSAMlkyHF5VgRqhEJ8gFlAJZlpWAVCiDUJZ5wkbkdHN37rqPBfpeNtZXWNfhiW7hZcFEVuQph0CO_yRzRhNRiCKA2QasXOe9QyPnzjbKLSUFuVIp1yrlypMEJtcqZRpyJ9uCRdmg_k1t3QXgagNgEPJp0UlfWWwr1NZh1Uvd2X8qvgE0SoJj</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Bivona, Trever G</creator><creator>Philips, Mark R</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20030401</creationdate><title>Ras pathway signaling on endomembranes</title><author>Bivona, Trever G ; Philips, Mark R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-7dff569e1ae61f996ad0ae09feb3d001a93f9a2d2e690b9e355b0e19afe0bb723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Cell Compartmentation - physiology</topic><topic>Endoplasmic Reticulum - physiology</topic><topic>Endosomes - metabolism</topic><topic>Eukaryotic Cells - metabolism</topic><topic>Golgi Apparatus - physiology</topic><topic>Humans</topic><topic>Intracellular Membranes - metabolism</topic><topic>MAP Kinase Signaling System - physiology</topic><topic>ras Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bivona, Trever G</creatorcontrib><creatorcontrib>Philips, Mark R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Current opinion in cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bivona, Trever G</au><au>Philips, Mark R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ras pathway signaling on endomembranes</atitle><jtitle>Current opinion in cell biology</jtitle><addtitle>Curr Opin Cell Biol</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>15</volume><issue>2</issue><spage>136</spage><epage>142</epage><pages>136-142</pages><issn>0955-0674</issn><eissn>1879-0410</eissn><abstract>Until recently, the plasma membrane has been considered to be a unique platform from which emanate the signaling events regulating or regulated by Ras and its close relatives. 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| ispartof | Current opinion in cell biology, 2003-04, Vol.15 (2), p.136-142 |
| issn | 0955-0674 1879-0410 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Compartmentation - physiology Endoplasmic Reticulum - physiology Endosomes - metabolism Eukaryotic Cells - metabolism Golgi Apparatus - physiology Humans Intracellular Membranes - metabolism MAP Kinase Signaling System - physiology ras Proteins - metabolism |
| title | Ras pathway signaling on endomembranes |
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