Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells

High-density lipoprotein (HDL)-induced activation of the Ras/MAPK pathway can be mediated by protein kinase C (PKC)-dependent and independent pathways. Although both pathways co-exist in cells, we showed that binding of HDL to scavenger receptor BI (SR-BI) in CHO cells activates Ras and MAPK in a PK...

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Veröffentlicht in:	Cellular signalling 2006-07, Vol.18 (7), p.1006-1016
Hauptverfasser:	Rentero, Carles, Evans, Rachael, Wood, Peta, Tebar, Francesc, Vilà de Muga, Sandra, Cubells, Laia, de Diego, Iñaki, Hayes, Toni E., Hughes, William E., Pol, Albert, Rye, Kerry-Anne, Enrich, Carlos, Grewal, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A6 Annexin A6 - biosynthesis Calcium - metabolism Cell Membrane - metabolism CHO Cells Cholesterol - metabolism Cricetinae Cricetulus Enzyme Activation Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors H-Ras HDL Humans Lipoproteins, HDL - physiology Lipoproteins, HDL3 MAP Kinase Kinase 1 - metabolism MAP Kinase Kinase 2 - metabolism MAPK Phosphatidylinositol 3-Kinases - physiology Phosphorylation PKC Protein Kinase C - physiology ras Proteins - antagonists & inhibitors Signal Transduction
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