The ras-binding domain of ral GDS-like protein-2 as a ras inhibitor in smooth muscle cells

This study was undertaken to determine whether the response of smooth muscle cells to mitogens can be inhibited by inactivating ras with the ral GDS like protein-2 ras-binding domain (RGL2-RBD). RGL2 is a member of the ral GDS family of proteins that contains a carboxy terminal ras-binding domain wh...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-06, Vol.305 (4), p.934-940
Hauptverfasser:	Fischer, Thomas H., Brittain, Julie, Trabalzini, Lorenza, Banes, Albert J., White, Gilbert C., Smith, Carr J., Nichols, Timothy C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cell Division Cells, Cultured Growth factor MAP Kinase Signaling System Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - metabolism Platelet-Derived Growth Factor - pharmacology Proliferation Protein Structure, Tertiary Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors Proto-Oncogene Proteins p21(ras) - metabolism rab GTP-Binding Proteins - chemistry rab GTP-Binding Proteins - metabolism Ral GDS-like protein-2 Ras Rats Smooth muscle cells
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