Sudden infant death syndrome: normal QT interval on ECGs of relatives

Genetically determined prolongation of the QT interval on ECGs has been proposed as one basic pathogenetic mechanism for the sudden infant death syndrome (SIDS). ECG studies in a total of 108 first-degree relatives of 26 patients with this syndrome in comparison with 99 such subjects from 22 control...

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Veröffentlicht in:	Pediatrics (Evanston) 1977-07, Vol.60 (1), p.51-54
Hauptverfasser:	Kukolich, M K, Telsey, A, Ott, J, Motulsky, A G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Child Electrocardiography Female Heart - physiopathology Humans Infant Infant, Newborn Male Sudden Infant Death - genetics Sudden Infant Death - physiopathology
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creator	Kukolich, M K Telsey, A Ott, J Motulsky, A G
description	Genetically determined prolongation of the QT interval on ECGs has been proposed as one basic pathogenetic mechanism for the sudden infant death syndrome (SIDS). ECG studies in a total of 108 first-degree relatives of 26 patients with this syndrome in comparison with 99 such subjects from 22 control families failed to show any significant differences in the QT interval in these two groups. Hereditary prolongation of the QT interval is therefore unlikely to be a significant factor in the etiology of the vast majority of cases of SIDS.
doi_str_mv	10.1542/peds.60.1.51
format	Article
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ECG studies in a total of 108 first-degree relatives of 26 patients with this syndrome in comparison with 99 such subjects from 22 control families failed to show any significant differences in the QT interval in these two groups. 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Hereditary prolongation of the QT interval is therefore unlikely to be a significant factor in the etiology of the vast majority of cases of SIDS.</description><subject>Adult</subject><subject>Child</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart - physiopathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Sudden Infant Death - genetics</subject><subject>Sudden Infant Death - physiopathology</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAURi3EqxQ2RgZPTCRcP24ebKgqBakSQpTZcmNbBCVxsZNK_fekasV075GOvuEQcssgZSj548aamGYjpMhOyIRBWSSS53hKJgCCJRIAL8lVjD8AIDHnF-S8yLNcyAmZfw7G2I7WndNdT43V_TeNu84E39on2vnQ6oZ-rEaht2E7_r6j89kiUu9osI3u662N1-TM6Sbam-Odkq-X-Wr2mizfF2-z52VS8QL7RK65KDhbM-mMBihElRvtqhIYcjBGF7LS6DLOM1ZiBSMbRI6lYKx0mZRiSu4Pu5vgfwcbe9XWsbJNozvrh6gKUSKyko_iw0Gsgo8xWKc2oW512CkGah9N7aOpbASFbNTvjrvDurXmXz5UEn_X_GaG</recordid><startdate>197707</startdate><enddate>197707</enddate><creator>Kukolich, M K</creator><creator>Telsey, A</creator><creator>Ott, J</creator><creator>Motulsky, A G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197707</creationdate><title>Sudden infant death syndrome: normal QT interval on ECGs of relatives</title><author>Kukolich, M K ; Telsey, A ; Ott, J ; Motulsky, A G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-4b23821b14fda0083c7dafc901520dda84ca5f6226195c0a84d552593119f6443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adult</topic><topic>Child</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart - physiopathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Sudden Infant Death - genetics</topic><topic>Sudden Infant Death - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kukolich, M K</creatorcontrib><creatorcontrib>Telsey, A</creatorcontrib><creatorcontrib>Ott, J</creatorcontrib><creatorcontrib>Motulsky, A G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kukolich, M K</au><au>Telsey, A</au><au>Ott, J</au><au>Motulsky, A G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sudden infant death syndrome: normal QT interval on ECGs of relatives</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1977-07</date><risdate>1977</risdate><volume>60</volume><issue>1</issue><spage>51</spage><epage>54</epage><pages>51-54</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>Genetically determined prolongation of the QT interval on ECGs has been proposed as one basic pathogenetic mechanism for the sudden infant death syndrome (SIDS). 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source	MEDLINE; EZB Electronic Journals Library
subjects	Adult Child Electrocardiography Female Heart - physiopathology Humans Infant Infant, Newborn Male Sudden Infant Death - genetics Sudden Infant Death - physiopathology
title	Sudden infant death syndrome: normal QT interval on ECGs of relatives
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