Immune complexes and complement catabolism in ankylosing spondylitis

Immune complexes and complement catabolism in ankylosing spondylitis

In serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125I‐Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immuno‐chemical method. Compared to results in 30 blood donors, the Clq binding activity was si...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Arthritis and rheumatism 1977-05, Vol.20 (4), p.913-916
Hauptverfasser: Gabay, R., Zubler, R. H., Nydegger, U. E., Lambert, P. H.
Format: Artikel
Sprache:eng
Schlagworte:
Antigen-Antibody Complex
Arthritis, Rheumatoid - immunology
Complement System Proteins - metabolism
Humans
Immune Complex Diseases
Protein Binding
Spondylitis, Ankylosing - immunology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 916
container_issue 4
container_start_page 913
container_title Arthritis and rheumatism
container_volume 20
creator Gabay, R.
Zubler, R. H.
Nydegger, U. E.
Lambert, P. H.
description In serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125I‐Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immuno‐chemical method. Compared to results in 30 blood donors, the Clq binding activity was significantly ( > 2 SD ), although discretely, increased in 5 of 8 patients with seropositive AS, but not in other AS patients. All C3d levels were within the normal range. In a parallel investigation, increased Clq binding activity and C3d levels were found in 87% and 90%, respectively, of patients with seropositive rheumatoid arthritis.
doi_str_mv 10.1002/art.1780200402
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_83955140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>83955140</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3792-30220242e7b0b5b445255afa307368d2258129167ba95610a9c14eb0875a634b3</originalsourceid><addsrcrecordid>eNqFkEtPwzAQhC3EqxSunDjkxC1l_UriY1VelSohoXK27MRFBjsJcSLIv8fQSuXGaTU7syPth9AlhhkGIDeq62c4L4AAMCAHaII5ESlgig_RBOIypVzgU3QWwluUhHJ6go4xg0zgCbpdej_UJikb3zrzZUKi6mqnvKn7pFS90o2zwSe2jub76Jpg69cktE1djc72Npyjo41ywVzs5hS93N-tF4_p6ulhuZiv0pLmgqQUCAHCiMk1aK4Z44RztVEUcpoVFSG8wETgLNdK8AyDEiVmRkORc5VRpukUXW972675GEzopbehNM6p2jRDkAUVnMfPYnC2DZZdE0JnNrLtrFfdKDHIH2oyUpN7avHgatc8aG-qffwXU7TF1v60zoz_lMn58_pP9TdKEHdc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83955140</pqid></control><display><type>article</type><title>Immune complexes and complement catabolism in ankylosing spondylitis</title><source>MEDLINE</source><source>Wiley Journals</source><source>Alma/SFX Local Collection</source><creator>Gabay, R. ; Zubler, R. H. ; Nydegger, U. E. ; Lambert, P. H.</creator><creatorcontrib>Gabay, R. ; Zubler, R. H. ; Nydegger, U. E. ; Lambert, P. H.</creatorcontrib><description>In serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125I‐Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immuno‐chemical method. Compared to results in 30 blood donors, the Clq binding activity was significantly ( &gt; 2 SD ), although discretely, increased in 5 of 8 patients with seropositive AS, but not in other AS patients. All C3d levels were within the normal range. In a parallel investigation, increased Clq binding activity and C3d levels were found in 87% and 90%, respectively, of patients with seropositive rheumatoid arthritis.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780200402</identifier><identifier>PMID: 140691</identifier><language>eng</language><publisher>New York: John Wiley &amp; Sons, Inc</publisher><subject>Antigen-Antibody Complex ; Arthritis, Rheumatoid - immunology ; Complement System Proteins - metabolism ; Humans ; Immune Complex Diseases ; Protein Binding ; Spondylitis, Ankylosing - immunology</subject><ispartof>Arthritis and rheumatism, 1977-05, Vol.20 (4), p.913-916</ispartof><rights>Copyright © 1977 American College of Rheumatology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3792-30220242e7b0b5b445255afa307368d2258129167ba95610a9c14eb0875a634b3</citedby><cites>FETCH-LOGICAL-c3792-30220242e7b0b5b445255afa307368d2258129167ba95610a9c14eb0875a634b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.1780200402$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.1780200402$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/140691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gabay, R.</creatorcontrib><creatorcontrib>Zubler, R. H.</creatorcontrib><creatorcontrib>Nydegger, U. E.</creatorcontrib><creatorcontrib>Lambert, P. H.</creatorcontrib><title>Immune complexes and complement catabolism in ankylosing spondylitis</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>In serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125I‐Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immuno‐chemical method. Compared to results in 30 blood donors, the Clq binding activity was significantly ( &gt; 2 SD ), although discretely, increased in 5 of 8 patients with seropositive AS, but not in other AS patients. All C3d levels were within the normal range. In a parallel investigation, increased Clq binding activity and C3d levels were found in 87% and 90%, respectively, of patients with seropositive rheumatoid arthritis.</description><subject>Antigen-Antibody Complex</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Complement System Proteins - metabolism</subject><subject>Humans</subject><subject>Immune Complex Diseases</subject><subject>Protein Binding</subject><subject>Spondylitis, Ankylosing - immunology</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC3EqxSunDjkxC1l_UriY1VelSohoXK27MRFBjsJcSLIv8fQSuXGaTU7syPth9AlhhkGIDeq62c4L4AAMCAHaII5ESlgig_RBOIypVzgU3QWwluUhHJ6go4xg0zgCbpdej_UJikb3zrzZUKi6mqnvKn7pFS90o2zwSe2jub76Jpg69cktE1djc72Npyjo41ywVzs5hS93N-tF4_p6ulhuZiv0pLmgqQUCAHCiMk1aK4Z44RztVEUcpoVFSG8wETgLNdK8AyDEiVmRkORc5VRpukUXW972675GEzopbehNM6p2jRDkAUVnMfPYnC2DZZdE0JnNrLtrFfdKDHIH2oyUpN7avHgatc8aG-qffwXU7TF1v60zoz_lMn58_pP9TdKEHdc</recordid><startdate>197705</startdate><enddate>197705</enddate><creator>Gabay, R.</creator><creator>Zubler, R. H.</creator><creator>Nydegger, U. E.</creator><creator>Lambert, P. H.</creator><general>John Wiley &amp; Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197705</creationdate><title>Immune complexes and complement catabolism in ankylosing spondylitis</title><author>Gabay, R. ; Zubler, R. H. ; Nydegger, U. E. ; Lambert, P. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3792-30220242e7b0b5b445255afa307368d2258129167ba95610a9c14eb0875a634b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Antigen-Antibody Complex</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Complement System Proteins - metabolism</topic><topic>Humans</topic><topic>Immune Complex Diseases</topic><topic>Protein Binding</topic><topic>Spondylitis, Ankylosing - immunology</topic><toplevel>online_resources</toplevel><creatorcontrib>Gabay, R.</creatorcontrib><creatorcontrib>Zubler, R. H.</creatorcontrib><creatorcontrib>Nydegger, U. E.</creatorcontrib><creatorcontrib>Lambert, P. H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gabay, R.</au><au>Zubler, R. H.</au><au>Nydegger, U. E.</au><au>Lambert, P. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune complexes and complement catabolism in ankylosing spondylitis</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1977-05</date><risdate>1977</risdate><volume>20</volume><issue>4</issue><spage>913</spage><epage>916</epage><pages>913-916</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><abstract>In serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125I‐Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immuno‐chemical method. Compared to results in 30 blood donors, the Clq binding activity was significantly ( &gt; 2 SD ), although discretely, increased in 5 of 8 patients with seropositive AS, but not in other AS patients. All C3d levels were within the normal range. In a parallel investigation, increased Clq binding activity and C3d levels were found in 87% and 90%, respectively, of patients with seropositive rheumatoid arthritis.</abstract><cop>New York</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>140691</pmid><doi>10.1002/art.1780200402</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0004-3591
ispartof Arthritis and rheumatism, 1977-05, Vol.20 (4), p.913-916
issn 0004-3591
1529-0131
language eng
recordid cdi_proquest_miscellaneous_83955140
source MEDLINE; Wiley Journals; Alma/SFX Local Collection
subjects Antigen-Antibody Complex
Arthritis, Rheumatoid - immunology
Complement System Proteins - metabolism
Humans
Immune Complex Diseases
Protein Binding
Spondylitis, Ankylosing - immunology
title Immune complexes and complement catabolism in ankylosing spondylitis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T08%3A45%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immune%20complexes%20and%20complement%20catabolism%20in%20ankylosing%20spondylitis&rft.jtitle=Arthritis%20and%20rheumatism&rft.au=Gabay,%20R.&rft.date=1977-05&rft.volume=20&rft.issue=4&rft.spage=913&rft.epage=916&rft.pages=913-916&rft.issn=0004-3591&rft.eissn=1529-0131&rft_id=info:doi/10.1002/art.1780200402&rft_dat=%3Cproquest_cross%3E83955140%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83955140&rft_id=info:pmid/140691&rfr_iscdi=true