GLC Determination of Acetohexamide and Hydroxyhexamide in Biological Fluids

A sensitive and specific GLC assay was developed for acetohexamide and hydroxyhexamide, its major metabolite, in plasma and urine. The assay uses tolbutamide as a mass internal standard. Compounds are extracted from acidified plasma or urine with toluene, converted to methylated derivatives with dim...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1977-05, Vol.66 (5), p.635-638
Hauptverfasser:	Kleber, J.W., Galloway, J.A., Rodda, B.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetohexamide - analogs & derivatives Acetohexamide - analysis Acetohexamide - blood Acetohexamide - urine acetohexamide and hydroxyhexamide Acetohexamide-GLC analysis Acetohexamide—GLC analysis, human plasma and urine Antidiabetic agents-acetohexamide Antidiabetic agents—acetohexamide, GLC analysis, human plasma and urine Biological Availability Blood Glucose - analysis Chromatography, Gas GLC analysis GLC-analyses GLC—analyses, acetohexamide and hydroxyhexamide, human plasma and urine human plasma and urine Humans Hydroxyhexamide-GLC analysis Hydroxyhexamide—GLC analysis, human plasma and urine Insulin - blood Mass Spectrometry Methods Tablets Time Factors
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