Establishment of mouse embryo cells in vitro: Relationship of DNA synthesis, senescence and malignant transformation

Mouse embryo cells exhibited a decline in proliferative capacity with increasing in vitro age. The ability of these monolayer cells to undergo DNA synthesis as a function of culture age was examined, and a progressive decline in the percentage of cells able to incorporate [ 3H]thymidine was found; i...

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Veröffentlicht in:	Experimental cell research 1977, Vol.107 (2), p.277-284
Hauptverfasser:	Meek, R.L., Bowman, P.D., Daniel, C.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Division Cell Nucleolus - ultrastructure Cell Survival Cell Transformation, Neoplastic Cells, Cultured Cytoplasm - ultrastructure DNA - biosynthesis Embryo, Mammalian - cytology Embryo, Nonmammalian Thymidine - metabolism Time Factors
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