Effect of Primidone Concentration on Glass Transition Temperature and Dissolution of Solid Dispersion Systems Containing Primidone and Citric Acid
The glass transition temperatures of glasses containing various concentrations of primidone in citric acid were measured and found to increase as the primidone concentration increased. Dissolution studies of these systems and particle-size measurements of primidone precipitated during dissolution of...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1977-06, Vol.66 (6), p.825-828 |
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| container_end_page | 828 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 66 |
| creator | Summers, M.P. Enever, R.P. |
| description | The glass transition temperatures of glasses containing various concentrations of primidone in citric acid were measured and found to increase as the primidone concentration increased. Dissolution studies of these systems and particle-size measurements of primidone precipitated during dissolution of devitrified glasses suggest that the increase in the dissolution rate of the devitrified systems is due to both the small size of the precipitated crystals and the excellent wettability of these systems. |
| doi_str_mv | 10.1002/jps.2600660622 |
| format | Article |
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Dissolution studies of these systems and particle-size measurements of primidone precipitated during dissolution of devitrified glasses suggest that the increase in the dissolution rate of the devitrified systems is due to both the small size of the precipitated crystals and the excellent wettability of these systems.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600660622</identifier><identifier>PMID: 874784</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Anticonvulsants-primidone ; Anticonvulsants—primidone, solid dispersion systems with citric acid, effect of concentration on glass transition temperature and dissolution ; Chemistry, Pharmaceutical ; Citrates ; Citric acid-solid dispersion systems with primidone ; Citric acid—solid dispersion systems with primidone, effect of primidone concentration on glass transition temperature and dissolution ; Crystallization ; Dissolution-primidone-citric acid solid dispersion systems ; Dissolution—primidone- citric acid solid dispersion systems, effect of primidone concentration ; effect of concentration on glass transition temperature and dissolution ; effect of primidone concentration ; effect of primidone concentration on glass transition temperature and dissolution ; Glass transition temperature-primidone-citric acid solid dispersion systems ; Glass transition temperature—primidone-citric acid solid dispersion systems, effect of primidone concentration ; Particle Size ; Primidone ; Primidone-solid dispersion systems with citric acid ; Primidone—solid dispersion systems with citric acid, effect of concentration on glass transition temperature and dissolution ; solid dispersion systems with citric acid ; Solid dispersion systems-primidone-citric acid ; Solid dispersion systems—primidone-citric acid, effect of primidone concentration on glass transition temperature and dissolution ; Solubility ; Suspensions ; Temperature ; Thermodynamics ; Time Factors</subject><ispartof>Journal of pharmaceutical sciences, 1977-06, Vol.66 (6), p.825-828</ispartof><rights>1977 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1977 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4262-766058c5788dbc730e478f2208644d504bf9d74e1a695b930384ddbc9016fe1d3</citedby><cites>FETCH-LOGICAL-c4262-766058c5788dbc730e478f2208644d504bf9d74e1a695b930384ddbc9016fe1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600660622$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600660622$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/874784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Summers, M.P.</creatorcontrib><creatorcontrib>Enever, R.P.</creatorcontrib><title>Effect of Primidone Concentration on Glass Transition Temperature and Dissolution of Solid Dispersion Systems Containing Primidone and Citric Acid</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The glass transition temperatures of glasses containing various concentrations of primidone in citric acid were measured and found to increase as the primidone concentration increased. Dissolution studies of these systems and particle-size measurements of primidone precipitated during dissolution of devitrified glasses suggest that the increase in the dissolution rate of the devitrified systems is due to both the small size of the precipitated crystals and the excellent wettability of these systems.</description><subject>Anticonvulsants-primidone</subject><subject>Anticonvulsants—primidone, solid dispersion systems with citric acid, effect of concentration on glass transition temperature and dissolution</subject><subject>Chemistry, Pharmaceutical</subject><subject>Citrates</subject><subject>Citric acid-solid dispersion systems with primidone</subject><subject>Citric acid—solid dispersion systems with primidone, effect of primidone concentration on glass transition temperature and dissolution</subject><subject>Crystallization</subject><subject>Dissolution-primidone-citric acid solid dispersion systems</subject><subject>Dissolution—primidone- citric acid solid dispersion systems, effect of primidone concentration</subject><subject>effect of concentration on glass transition temperature and dissolution</subject><subject>effect of primidone concentration</subject><subject>effect of primidone concentration on glass transition temperature and dissolution</subject><subject>Glass transition temperature-primidone-citric acid solid dispersion systems</subject><subject>Glass transition temperature—primidone-citric acid solid dispersion systems, effect of primidone concentration</subject><subject>Particle Size</subject><subject>Primidone</subject><subject>Primidone-solid dispersion systems with citric acid</subject><subject>Primidone—solid dispersion systems with citric acid, effect of concentration on glass transition temperature and dissolution</subject><subject>solid dispersion systems with citric acid</subject><subject>Solid dispersion systems-primidone-citric acid</subject><subject>Solid dispersion systems—primidone-citric acid, effect of primidone concentration on glass transition temperature and dissolution</subject><subject>Solubility</subject><subject>Suspensions</subject><subject>Temperature</subject><subject>Thermodynamics</subject><subject>Time Factors</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS1EgW3hyomDT9yy2I5jJ8dq225BVanYRUhcLK89Ri5JvLUTYP9GfzHepirlgJAsWZr3zbNnHkKvKZlTQti7622aM0GIEEQw9gTNaMVIIQiVT9EsA6woK968QIcpXZOMkap6jp7Vksuaz9DtqXNgBhwcvoq-8zb0gBehN9APUQ8-9DifZatTwuuo--TvamvotpD1MQLWvcUnPqXQjhPv8Cq0_q6YobSvrXZpgC7tnQfte99_e_Tc3mDhh-gNPjbevkQHTrcJXt3fR-jz2el6cV5cfFy-XxxfFIYzwQqZB65qU8m6thsjSwJ5IscYqQXntiJ84xorOVAtmmrTlKSsuc1kQ6hwQG15hN5OvtsYbkZIg-p8MtC2uocwJlWXTUmlFBmcT6CJIaUITm3z33XcKUrUPgOVM1B_MsgNb-6dx00H9gGflp7lZpJ_-hZ2_zFTH65Wf1kXU6_PC_310KvjdyVkKSv15XKpzk5k80kyrr5mvp54yJv84SGqZDzkeK2POXdlg__XFL8BX_e2aA</recordid><startdate>197706</startdate><enddate>197706</enddate><creator>Summers, M.P.</creator><creator>Enever, R.P.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197706</creationdate><title>Effect of Primidone Concentration on Glass Transition Temperature and Dissolution of Solid Dispersion Systems Containing Primidone and Citric Acid</title><author>Summers, M.P. ; Enever, R.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4262-766058c5788dbc730e478f2208644d504bf9d74e1a695b930384ddbc9016fe1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Anticonvulsants-primidone</topic><topic>Anticonvulsants—primidone, solid dispersion systems with citric acid, effect of concentration on glass transition temperature and dissolution</topic><topic>Chemistry, Pharmaceutical</topic><topic>Citrates</topic><topic>Citric acid-solid dispersion systems with primidone</topic><topic>Citric acid—solid dispersion systems with primidone, effect of primidone concentration on glass transition temperature and dissolution</topic><topic>Crystallization</topic><topic>Dissolution-primidone-citric acid solid dispersion systems</topic><topic>Dissolution—primidone- citric acid solid dispersion systems, effect of primidone concentration</topic><topic>effect of concentration on glass transition temperature and dissolution</topic><topic>effect of primidone concentration</topic><topic>effect of primidone concentration on glass transition temperature and dissolution</topic><topic>Glass transition temperature-primidone-citric acid solid dispersion systems</topic><topic>Glass transition temperature—primidone-citric acid solid dispersion systems, effect of primidone concentration</topic><topic>Particle Size</topic><topic>Primidone</topic><topic>Primidone-solid dispersion systems with citric acid</topic><topic>Primidone—solid dispersion systems with citric acid, effect of concentration on glass transition temperature and dissolution</topic><topic>solid dispersion systems with citric acid</topic><topic>Solid dispersion systems-primidone-citric acid</topic><topic>Solid dispersion systems—primidone-citric acid, effect of primidone concentration on glass transition temperature and dissolution</topic><topic>Solubility</topic><topic>Suspensions</topic><topic>Temperature</topic><topic>Thermodynamics</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Summers, M.P.</creatorcontrib><creatorcontrib>Enever, R.P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Summers, M.P.</au><au>Enever, R.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Primidone Concentration on Glass Transition Temperature and Dissolution of Solid Dispersion Systems Containing Primidone and Citric Acid</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1977-06</date><risdate>1977</risdate><volume>66</volume><issue>6</issue><spage>825</spage><epage>828</epage><pages>825-828</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The glass transition temperatures of glasses containing various concentrations of primidone in citric acid were measured and found to increase as the primidone concentration increased. Dissolution studies of these systems and particle-size measurements of primidone precipitated during dissolution of devitrified glasses suggest that the increase in the dissolution rate of the devitrified systems is due to both the small size of the precipitated crystals and the excellent wettability of these systems.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>874784</pmid><doi>10.1002/jps.2600660622</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1977-06, Vol.66 (6), p.825-828 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83931776 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Anticonvulsants-primidone Anticonvulsants—primidone, solid dispersion systems with citric acid, effect of concentration on glass transition temperature and dissolution Chemistry, Pharmaceutical Citrates Citric acid-solid dispersion systems with primidone Citric acid—solid dispersion systems with primidone, effect of primidone concentration on glass transition temperature and dissolution Crystallization Dissolution-primidone-citric acid solid dispersion systems Dissolution—primidone- citric acid solid dispersion systems, effect of primidone concentration effect of concentration on glass transition temperature and dissolution effect of primidone concentration effect of primidone concentration on glass transition temperature and dissolution Glass transition temperature-primidone-citric acid solid dispersion systems Glass transition temperature—primidone-citric acid solid dispersion systems, effect of primidone concentration Particle Size Primidone Primidone-solid dispersion systems with citric acid Primidone—solid dispersion systems with citric acid, effect of concentration on glass transition temperature and dissolution solid dispersion systems with citric acid Solid dispersion systems-primidone-citric acid Solid dispersion systems—primidone-citric acid, effect of primidone concentration on glass transition temperature and dissolution Solubility Suspensions Temperature Thermodynamics Time Factors |
| title | Effect of Primidone Concentration on Glass Transition Temperature and Dissolution of Solid Dispersion Systems Containing Primidone and Citric Acid |
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