Canine Gastric Acid Secretion and Blood Flow Measurement in Hemorrhagic Shock
In 5 anesthetized and 5 conscious dogs, gastric blood flow was measured with 15-μ labeled microspheres. Acid secretion and regional flow under control conditions (mean blood pressure (BP) = 100 mm Hg), after 1 hr of hemorrhagic shock (mean BP = 40 mm Hg), and 60 min after re transfusion of shed bloo...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1977-07, Vol.73 (1), p.75-78 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Shirazi, Siroos S. Mueller, Thomas M. Hardy, Bruce M. |
| description | In 5 anesthetized and 5 conscious dogs, gastric blood flow was measured with 15-μ labeled microspheres. Acid secretion and regional flow under control conditions (mean blood pressure (BP) = 100 mm Hg), after 1 hr of hemorrhagic shock (mean BP = 40 mm Hg), and 60 min after re transfusion of shed blood (mean BP = 100 mm Hg) were measured. Results are expressed as mean milliequivalents per hour for acid secretion and milliliters per minute x 100 g of tissue for blood flow.
These results indicate that (1) acid secretion and regional blood flow are significantly higher in conscious dogs; (2) hemorrhagic shock caused a significant reduction of acid secretion and blood flow within the gastric tissue; (3) blood flow to fundic mucosa decreases more than antral mucosa (P < 0.05) in anesthetized dogs; and (4) although re transfusion increased regional blood flow, it was not restored to preshock level. Because the perfusion of fundic mucosa is more sensitive to hemorrhagic shock, this may partially explain the propensity of stress ulcers to be located in the fundus of the stomach. |
| doi_str_mv | 10.1016/S0016-5085(19)32276-0 |
| format | Article |
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These results indicate that (1) acid secretion and regional blood flow are significantly higher in conscious dogs; (2) hemorrhagic shock caused a significant reduction of acid secretion and blood flow within the gastric tissue; (3) blood flow to fundic mucosa decreases more than antral mucosa (P < 0.05) in anesthetized dogs; and (4) although re transfusion increased regional blood flow, it was not restored to preshock level. Because the perfusion of fundic mucosa is more sensitive to hemorrhagic shock, this may partially explain the propensity of stress ulcers to be located in the fundus of the stomach.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/S0016-5085(19)32276-0</identifier><identifier>PMID: 863203</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Blood Transfusion, Autologous ; Dogs ; Gastric Juice - secretion ; Gastric Mucosa - blood supply ; Gastric Mucosa - secretion ; Microspheres ; Radioisotopes ; Regional Blood Flow ; Shock, Hemorrhagic - physiopathology ; Shock, Hemorrhagic - therapy ; Stomach Ulcer - etiology</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1977-07, Vol.73 (1), p.75-78</ispartof><rights>1977 AGA Institute</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-b797f898bf5c75be14cf11d41af37a85d14d464725f273959fe520853c1bb2d23</citedby><cites>FETCH-LOGICAL-c406t-b797f898bf5c75be14cf11d41af37a85d14d464725f273959fe520853c1bb2d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0016-5085(19)32276-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/863203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shirazi, Siroos S.</creatorcontrib><creatorcontrib>Mueller, Thomas M.</creatorcontrib><creatorcontrib>Hardy, Bruce M.</creatorcontrib><title>Canine Gastric Acid Secretion and Blood Flow Measurement in Hemorrhagic Shock</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>In 5 anesthetized and 5 conscious dogs, gastric blood flow was measured with 15-μ labeled microspheres. Acid secretion and regional flow under control conditions (mean blood pressure (BP) = 100 mm Hg), after 1 hr of hemorrhagic shock (mean BP = 40 mm Hg), and 60 min after re transfusion of shed blood (mean BP = 100 mm Hg) were measured. Results are expressed as mean milliequivalents per hour for acid secretion and milliliters per minute x 100 g of tissue for blood flow.
These results indicate that (1) acid secretion and regional blood flow are significantly higher in conscious dogs; (2) hemorrhagic shock caused a significant reduction of acid secretion and blood flow within the gastric tissue; (3) blood flow to fundic mucosa decreases more than antral mucosa (P < 0.05) in anesthetized dogs; and (4) although re transfusion increased regional blood flow, it was not restored to preshock level. Because the perfusion of fundic mucosa is more sensitive to hemorrhagic shock, this may partially explain the propensity of stress ulcers to be located in the fundus of the stomach.</description><subject>Animals</subject><subject>Blood Transfusion, Autologous</subject><subject>Dogs</subject><subject>Gastric Juice - secretion</subject><subject>Gastric Mucosa - blood supply</subject><subject>Gastric Mucosa - secretion</subject><subject>Microspheres</subject><subject>Radioisotopes</subject><subject>Regional Blood Flow</subject><subject>Shock, Hemorrhagic - physiopathology</subject><subject>Shock, Hemorrhagic - therapy</subject><subject>Stomach Ulcer - etiology</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPxDAQhC3E63j8A5BcISgCfsSJUyE4wR3SnSgOasuxN2BIYrATEP-eHEG0NLvFzOxqPoSOKTmnhGYXKzLMRBApTmlxxhnLs4RsoAkVTCaDxjbR5M-yi_ZifCGEFFzSHbQtM84In6DlVLeuBTzTsQvO4CvjLF6BCdA532LdWnxde2_xbe0_8RJ07AM00HbYtXgOjQ_hWT8NwdWzN68HaKvSdYTD372PHm9vHqbzZHE_u5teLRKTkqxLyrzIK1nIshImFyXQ1FSU2pTqiudaCktTm2ZpzkTFcl6IogLBhhLc0LJklvF9dDLefQv-vYfYqcZFA3WtW_B9VJIXTAqxNorRaIKPMUCl3oJrdPhSlKg1RfVDUa0RKVqoH4qKDLmj3wd92YD9S43YBvlylGEo-eEgqGgctAasC2A6Zb3758E3aFqAFg</recordid><startdate>197707</startdate><enddate>197707</enddate><creator>Shirazi, Siroos S.</creator><creator>Mueller, Thomas M.</creator><creator>Hardy, Bruce M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197707</creationdate><title>Canine Gastric Acid Secretion and Blood Flow Measurement in Hemorrhagic Shock</title><author>Shirazi, Siroos S. ; Mueller, Thomas M. ; Hardy, Bruce M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-b797f898bf5c75be14cf11d41af37a85d14d464725f273959fe520853c1bb2d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Blood Transfusion, Autologous</topic><topic>Dogs</topic><topic>Gastric Juice - secretion</topic><topic>Gastric Mucosa - blood supply</topic><topic>Gastric Mucosa - secretion</topic><topic>Microspheres</topic><topic>Radioisotopes</topic><topic>Regional Blood Flow</topic><topic>Shock, Hemorrhagic - physiopathology</topic><topic>Shock, Hemorrhagic - therapy</topic><topic>Stomach Ulcer - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shirazi, Siroos S.</creatorcontrib><creatorcontrib>Mueller, Thomas M.</creatorcontrib><creatorcontrib>Hardy, Bruce M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shirazi, Siroos S.</au><au>Mueller, Thomas M.</au><au>Hardy, Bruce M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Canine Gastric Acid Secretion and Blood Flow Measurement in Hemorrhagic Shock</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1977-07</date><risdate>1977</risdate><volume>73</volume><issue>1</issue><spage>75</spage><epage>78</epage><pages>75-78</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><abstract>In 5 anesthetized and 5 conscious dogs, gastric blood flow was measured with 15-μ labeled microspheres. Acid secretion and regional flow under control conditions (mean blood pressure (BP) = 100 mm Hg), after 1 hr of hemorrhagic shock (mean BP = 40 mm Hg), and 60 min after re transfusion of shed blood (mean BP = 100 mm Hg) were measured. Results are expressed as mean milliequivalents per hour for acid secretion and milliliters per minute x 100 g of tissue for blood flow.
These results indicate that (1) acid secretion and regional blood flow are significantly higher in conscious dogs; (2) hemorrhagic shock caused a significant reduction of acid secretion and blood flow within the gastric tissue; (3) blood flow to fundic mucosa decreases more than antral mucosa (P < 0.05) in anesthetized dogs; and (4) although re transfusion increased regional blood flow, it was not restored to preshock level. Because the perfusion of fundic mucosa is more sensitive to hemorrhagic shock, this may partially explain the propensity of stress ulcers to be located in the fundus of the stomach.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>863203</pmid><doi>10.1016/S0016-5085(19)32276-0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0016-5085 |
| ispartof | Gastroenterology (New York, N.Y. 1943), 1977-07, Vol.73 (1), p.75-78 |
| issn | 0016-5085 1528-0012 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83928552 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection |
| subjects | Animals Blood Transfusion, Autologous Dogs Gastric Juice - secretion Gastric Mucosa - blood supply Gastric Mucosa - secretion Microspheres Radioisotopes Regional Blood Flow Shock, Hemorrhagic - physiopathology Shock, Hemorrhagic - therapy Stomach Ulcer - etiology |
| title | Canine Gastric Acid Secretion and Blood Flow Measurement in Hemorrhagic Shock |
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