Thymidylate synthetase and dihydrofolic acid reductase in the stimulated human lymphocyte

The phytohemagglutinin (PHA)‐stimulated human lymphocytes demonstrated trace or no activity of (dihydro) folate acid reductase using three methods including a radioassay, but demonstrated ample activity of thymidylate synthetase. This was true regardless of the day of harvest, (first through seventh...

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Veröffentlicht in:	Journal of cellular physiology 1978-04, Vol.95 (1), p.49-55
Hauptverfasser:	Haurani, Farid I., Kardinal, Carl G., Biermann, William A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Deoxyuridine - metabolism Floxuridine - pharmacology Humans Lectins - pharmacology Lymphocytes - drug effects Lymphocytes - enzymology Lymphocytes - metabolism Methotrexate - pharmacology Methyltransferases - metabolism Tetrahydrofolate Dehydrogenase - metabolism Thymidine - metabolism Thymidylate Synthase - metabolism
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