Computer aids to protein sequence determination
Computer programs are described to aid in determining the sequence of the amino acids in a protein from knowledge of the structure of overlapping peptides obtained by hydrolysis of the protein. The programs are designed for use in planning experiments, locating experimental errors, determining all p...
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| Veröffentlicht in: | Journal of theoretical biology 1965, Vol.8 (1), p.97-112 |
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| Format: | Artikel |
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| container_end_page | 112 |
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| container_issue | 1 |
| container_start_page | 97 |
| container_title | Journal of theoretical biology |
| container_volume | 8 |
| creator | Dayhoff, M.O. |
| description | Computer programs are described to aid in determining the sequence of the amino acids in a protein from knowledge of the structure of overlapping peptides obtained by hydrolysis of the protein. The programs are designed for use in planning experiments, locating experimental errors, determining all possible sequences consistent with the experimental data and testing the reliability of the final answer. The system of Fortran computer programs accepts the experimental peptide structure data and presents results in acceptable chemical language. Examples are described utilizing different types of experimental information for partially or completely determining the sequence. The possibility of accurate systematic manipulation and presentation of data makes attractive a much wider range of experimental techniques than are now used. |
| doi_str_mv | 10.1016/0022-5193(65)90096-2 |
| format | Article |
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The programs are designed for use in planning experiments, locating experimental errors, determining all possible sequences consistent with the experimental data and testing the reliability of the final answer. The system of Fortran computer programs accepts the experimental peptide structure data and presents results in acceptable chemical language. Examples are described utilizing different types of experimental information for partially or completely determining the sequence. The possibility of accurate systematic manipulation and presentation of data makes attractive a much wider range of experimental techniques than are now used.</description><identifier>ISSN: 0022-5193</identifier><identifier>EISSN: 1095-8541</identifier><identifier>DOI: 10.1016/0022-5193(65)90096-2</identifier><identifier>PMID: 5875266</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Amino Acid Sequence ; amino acid sequences ; computer software ; Computers ; data analysis ; errors ; fortran computer language ; ibm 7090 ; Proteins ; Space life sciences</subject><ispartof>Journal of theoretical biology, 1965, Vol.8 (1), p.97-112</ispartof><rights>1965</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-88f0afc84bd1223d420f3e3dbeb23c9d0768ae6aaada57765b4fa6d675af8d9c3</citedby><cites>FETCH-LOGICAL-c381t-88f0afc84bd1223d420f3e3dbeb23c9d0768ae6aaada57765b4fa6d675af8d9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022519365900962$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5875266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dayhoff, M.O.</creatorcontrib><title>Computer aids to protein sequence determination</title><title>Journal of theoretical biology</title><addtitle>J Theor Biol</addtitle><description>Computer programs are described to aid in determining the sequence of the amino acids in a protein from knowledge of the structure of overlapping peptides obtained by hydrolysis of the protein. The programs are designed for use in planning experiments, locating experimental errors, determining all possible sequences consistent with the experimental data and testing the reliability of the final answer. The system of Fortran computer programs accepts the experimental peptide structure data and presents results in acceptable chemical language. Examples are described utilizing different types of experimental information for partially or completely determining the sequence. The possibility of accurate systematic manipulation and presentation of data makes attractive a much wider range of experimental techniques than are now used.</description><subject>Amino Acid Sequence</subject><subject>amino acid sequences</subject><subject>computer software</subject><subject>Computers</subject><subject>data analysis</subject><subject>errors</subject><subject>fortran computer language</subject><subject>ibm 7090</subject><subject>Proteins</subject><subject>Space life sciences</subject><issn>0022-5193</issn><issn>1095-8541</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4zj6DxS7El3UyaNJ040ggy8YcKGzDmlyK5FpMyat4L83dYZZurqL853L4UPonOBbgomYY0xpzknFrgW_qTCuRE4P0JTgiueSF-QQTffIMTqJ8RMnqGBigiZclpwKMUXzhW83Qw8h087GrPfZJvgeXJdF-BqgM5BZSHHrOt07352io0avI5zt7gytHh_eF8_58vXpZXG_zA2TpM-lbLBujCxqSyhltqC4YcBsDTVlprK4FFKD0FpbzctS8LpotLCi5LqRtjJshq62f9OctCP2qnXRwHqtO_BDVJJVRHLCElhsQRN8jAEatQmu1eFHEaxGT2qUoEYJSnD150nRVLvY_R_qFuy-tBOT8stt3miv9EdwUa3eKCYMk5IzgXEi7rYEJA3fDoKKxo3CrAtgemW9-3_CL6BpgFY</recordid><startdate>1965</startdate><enddate>1965</enddate><creator>Dayhoff, M.O.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1965</creationdate><title>Computer aids to protein sequence determination</title><author>Dayhoff, M.O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-88f0afc84bd1223d420f3e3dbeb23c9d0768ae6aaada57765b4fa6d675af8d9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>Amino Acid Sequence</topic><topic>amino acid sequences</topic><topic>computer software</topic><topic>Computers</topic><topic>data analysis</topic><topic>errors</topic><topic>fortran computer language</topic><topic>ibm 7090</topic><topic>Proteins</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dayhoff, M.O.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of theoretical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dayhoff, M.O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computer aids to protein sequence determination</atitle><jtitle>Journal of theoretical biology</jtitle><addtitle>J Theor Biol</addtitle><date>1965</date><risdate>1965</risdate><volume>8</volume><issue>1</issue><spage>97</spage><epage>112</epage><pages>97-112</pages><issn>0022-5193</issn><eissn>1095-8541</eissn><abstract>Computer programs are described to aid in determining the sequence of the amino acids in a protein from knowledge of the structure of overlapping peptides obtained by hydrolysis of the protein. The programs are designed for use in planning experiments, locating experimental errors, determining all possible sequences consistent with the experimental data and testing the reliability of the final answer. The system of Fortran computer programs accepts the experimental peptide structure data and presents results in acceptable chemical language. Examples are described utilizing different types of experimental information for partially or completely determining the sequence. The possibility of accurate systematic manipulation and presentation of data makes attractive a much wider range of experimental techniques than are now used.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>5875266</pmid><doi>10.1016/0022-5193(65)90096-2</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5193 |
| ispartof | Journal of theoretical biology, 1965, Vol.8 (1), p.97-112 |
| issn | 0022-5193 1095-8541 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83918513 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence amino acid sequences computer software Computers data analysis errors fortran computer language ibm 7090 Proteins Space life sciences |
| title | Computer aids to protein sequence determination |
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