Origin of an Elevated Plasma Alkaline Phosphatase Activity in Non-Jaundiced Patients
Summary Samples from 260 non-jaundiced patients with elevated plasma alkaline phosphatase activities were analysed for γ-glutamyltransferase and 5′-nucleotidase activity, and for alkaline phosphatase isoenzyme pattern. The plasma γ-glutamyltransferase activity was found to be a more sensitive index...
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| Veröffentlicht in: | Annals of clinical biochemistry 1978-01, Vol.15 (1-6), p.86-90 |
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| container_title | Annals of clinical biochemistry |
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| creator | Cleeve, H. J. W. |
| description | Summary Samples from 260 non-jaundiced patients with elevated plasma alkaline phosphatase activities were analysed for γ-glutamyltransferase and 5′-nucleotidase activity, and for alkaline phosphatase isoenzyme pattern. The plasma γ-glutamyltransferase activity was found to be a more sensitive index than that of plasma 5′-nucleotidase in confirming the presence of a liver component of the elevated plasma alkaline phosphatase. If the γ-glutamyltransferase level is normal it is probable that the increase in plasma alkaline phosphatase activity is of bone origin. However, an elevated γ-glutamyltransferase result does not exclude a bone component; in this situation plasma alkaline phosphatase isoenzymes should be estimated. The causes of elevated activities of plasma alkaline phosphatase, 5′-nucleotidase and γ-glutamyltransferase, found in this investigation were generally the same as those found by other workers. The effect of treatment by drugs on γ-glutamyltransferase, an inducible enzyme, needs more investigation. |
| doi_str_mv | 10.1177/000456327801500118 |
| format | Article |
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J. W.</creator><creatorcontrib>Cleeve, H. J. W.</creatorcontrib><description>Summary Samples from 260 non-jaundiced patients with elevated plasma alkaline phosphatase activities were analysed for γ-glutamyltransferase and 5′-nucleotidase activity, and for alkaline phosphatase isoenzyme pattern. The plasma γ-glutamyltransferase activity was found to be a more sensitive index than that of plasma 5′-nucleotidase in confirming the presence of a liver component of the elevated plasma alkaline phosphatase. If the γ-glutamyltransferase level is normal it is probable that the increase in plasma alkaline phosphatase activity is of bone origin. However, an elevated γ-glutamyltransferase result does not exclude a bone component; in this situation plasma alkaline phosphatase isoenzymes should be estimated. The causes of elevated activities of plasma alkaline phosphatase, 5′-nucleotidase and γ-glutamyltransferase, found in this investigation were generally the same as those found by other workers. The effect of treatment by drugs on γ-glutamyltransferase, an inducible enzyme, needs more investigation.</description><identifier>ISSN: 0004-5632</identifier><identifier>EISSN: 1758-1001</identifier><identifier>DOI: 10.1177/000456327801500118</identifier><identifier>PMID: 25039</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Alkaline Phosphatase - blood ; Bone and Bones - enzymology ; Bone Diseases - enzymology ; Clinical Enzyme Tests ; Female ; gamma-Glutamyltransferase - blood ; Humans ; Isoenzymes - blood ; Liver - enzymology ; Liver Diseases - enzymology ; Male ; Nucleotidases - blood</subject><ispartof>Annals of clinical biochemistry, 1978-01, Vol.15 (1-6), p.86-90</ispartof><rights>1978 Association for Clinical Biochemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-f947f12b45368c929e6a5dc5d3bda1ddc0ee6cfbbf1f872608065ad1bf1724113</citedby><cites>FETCH-LOGICAL-c380t-f947f12b45368c929e6a5dc5d3bda1ddc0ee6cfbbf1f872608065ad1bf1724113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cleeve, H. J. W.</creatorcontrib><title>Origin of an Elevated Plasma Alkaline Phosphatase Activity in Non-Jaundiced Patients</title><title>Annals of clinical biochemistry</title><addtitle>Ann Clin Biochem</addtitle><description>Summary Samples from 260 non-jaundiced patients with elevated plasma alkaline phosphatase activities were analysed for γ-glutamyltransferase and 5′-nucleotidase activity, and for alkaline phosphatase isoenzyme pattern. The plasma γ-glutamyltransferase activity was found to be a more sensitive index than that of plasma 5′-nucleotidase in confirming the presence of a liver component of the elevated plasma alkaline phosphatase. If the γ-glutamyltransferase level is normal it is probable that the increase in plasma alkaline phosphatase activity is of bone origin. However, an elevated γ-glutamyltransferase result does not exclude a bone component; in this situation plasma alkaline phosphatase isoenzymes should be estimated. The causes of elevated activities of plasma alkaline phosphatase, 5′-nucleotidase and γ-glutamyltransferase, found in this investigation were generally the same as those found by other workers. The effect of treatment by drugs on γ-glutamyltransferase, an inducible enzyme, needs more investigation.</description><subject>Adult</subject><subject>Alkaline Phosphatase - blood</subject><subject>Bone and Bones - enzymology</subject><subject>Bone Diseases - enzymology</subject><subject>Clinical Enzyme Tests</subject><subject>Female</subject><subject>gamma-Glutamyltransferase - blood</subject><subject>Humans</subject><subject>Isoenzymes - blood</subject><subject>Liver - enzymology</subject><subject>Liver Diseases - enzymology</subject><subject>Male</subject><subject>Nucleotidases - blood</subject><issn>0004-5632</issn><issn>1758-1001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAYhC1EBaXwB2DxxBZqO3HsjFVVvlTRDmWOHH-0LqlTYqdS_z0ORSxITK9Od89J7wFwi9EDxoyNEUIZzVPCOMIUIYz5GRhiRnmCozoHwz6Q9IlLcOX9NkrCELoAA0JRWgzBatHatXWwMVA4OKv1QQSt4LIWfifgpP4QtXUaLjeN329EEF7DiQz2YMMRRuytccmr6JyysqdEsNoFfw0GRtRe3_zcEXh_nK2mz8l88fQyncwTmXIUElNkzGBSZTTNuSxIoXNBlaQqrZTASkmkdS5NVRlsOCM54iinQuGoGckwTkfg_tS7b5vPTvtQ7qyXuq6F003nS54WOOeExiA5BWXbeN9qU-5buxPtscSo7Ics_w4Zobuf9q7aafWLfC8X3fHJ9WKty23TtS6--l_fF7Nheok</recordid><startdate>19780101</startdate><enddate>19780101</enddate><creator>Cleeve, H. J. W.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780101</creationdate><title>Origin of an Elevated Plasma Alkaline Phosphatase Activity in Non-Jaundiced Patients</title><author>Cleeve, H. J. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-f947f12b45368c929e6a5dc5d3bda1ddc0ee6cfbbf1f872608065ad1bf1724113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Alkaline Phosphatase - blood</topic><topic>Bone and Bones - enzymology</topic><topic>Bone Diseases - enzymology</topic><topic>Clinical Enzyme Tests</topic><topic>Female</topic><topic>gamma-Glutamyltransferase - blood</topic><topic>Humans</topic><topic>Isoenzymes - blood</topic><topic>Liver - enzymology</topic><topic>Liver Diseases - enzymology</topic><topic>Male</topic><topic>Nucleotidases - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cleeve, H. J. W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cleeve, H. J. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Origin of an Elevated Plasma Alkaline Phosphatase Activity in Non-Jaundiced Patients</atitle><jtitle>Annals of clinical biochemistry</jtitle><addtitle>Ann Clin Biochem</addtitle><date>1978-01-01</date><risdate>1978</risdate><volume>15</volume><issue>1-6</issue><spage>86</spage><epage>90</epage><pages>86-90</pages><issn>0004-5632</issn><eissn>1758-1001</eissn><abstract>Summary Samples from 260 non-jaundiced patients with elevated plasma alkaline phosphatase activities were analysed for γ-glutamyltransferase and 5′-nucleotidase activity, and for alkaline phosphatase isoenzyme pattern. The plasma γ-glutamyltransferase activity was found to be a more sensitive index than that of plasma 5′-nucleotidase in confirming the presence of a liver component of the elevated plasma alkaline phosphatase. If the γ-glutamyltransferase level is normal it is probable that the increase in plasma alkaline phosphatase activity is of bone origin. However, an elevated γ-glutamyltransferase result does not exclude a bone component; in this situation plasma alkaline phosphatase isoenzymes should be estimated. The causes of elevated activities of plasma alkaline phosphatase, 5′-nucleotidase and γ-glutamyltransferase, found in this investigation were generally the same as those found by other workers. The effect of treatment by drugs on γ-glutamyltransferase, an inducible enzyme, needs more investigation.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>25039</pmid><doi>10.1177/000456327801500118</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of clinical biochemistry, 1978-01, Vol.15 (1-6), p.86-90 |
| issn | 0004-5632 1758-1001 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83916825 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Alkaline Phosphatase - blood Bone and Bones - enzymology Bone Diseases - enzymology Clinical Enzyme Tests Female gamma-Glutamyltransferase - blood Humans Isoenzymes - blood Liver - enzymology Liver Diseases - enzymology Male Nucleotidases - blood |
| title | Origin of an Elevated Plasma Alkaline Phosphatase Activity in Non-Jaundiced Patients |
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