Role of Sialic Acid in Survival of Erythrocytes in the Circulation: Interaction of Neuraminidase-Treated and Untreated Erythrocytes with Spleen and Liver at the Cellular Level
Sialidase (neuraminidase; acylneuraminyl hydrolase; EC 3.2.1.18)-treated erythrocytes obtained from different species are susceptible to rapid elimination from the circulation and are sequestered in the liver and spleen. The present studies were concerned with the mechanism of this clearance and how...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1977-04, Vol.74 (4), p.1521-1524 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 74 |
| creator | Aminoff, David William F. Vorder Bruegge Bell, William C. Sarpolis, Keith Williams, Revius |
| description | Sialidase (neuraminidase; acylneuraminyl hydrolase; EC 3.2.1.18)-treated erythrocytes obtained from different species are susceptible to rapid elimination from the circulation and are sequestered in the liver and spleen. The present studies were concerned with the mechanism of this clearance and how it may relate to the normal physiological process of removing senescent erythrocytes from the circulation. The results obtained indicate a preferential recognition of sialidase-treated as compared to normal erythrocytes by mononuclear spleen cells and Kupffer cells of the liver. This recognition manifests itself in both autologous and homologous systems by adhesion of the complementary cells in the form of rosettes, and as such could explain the removal of enzyme-treated erythrocytes from the circulation with their accumulation in liver and spleen. This phenomenon may represent a normal physiological mechanism for removal of senescent erythrocytes containing decreased sialic acid. |
| doi_str_mv | 10.1073/pnas.74.4.1521 |
| format | Article |
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This recognition manifests itself in both autologous and homologous systems by adhesion of the complementary cells in the form of rosettes, and as such could explain the removal of enzyme-treated erythrocytes from the circulation with their accumulation in liver and spleen. This phenomenon may represent a normal physiological mechanism for removal of senescent erythrocytes containing decreased sialic acid.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.74.4.1521</identifier><identifier>PMID: 266192</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Biochemistry ; Blood ; Chemical suspensions ; Erythrocyte Aging ; Erythrocytes ; Erythrocytes - drug effects ; Erythrocytes - physiology ; Hepatocytes ; Kupffer cells ; Kupffer Cells - physiology ; Liver ; Liver - physiology ; Liver cells ; Male ; Neuraminidase - pharmacology ; Rats ; Sialic Acids - blood ; Spleen ; Spleen - physiology ; Spleen cells</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1977-04, Vol.74 (4), p.1521-1524</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-cf7b0f0380a7fd6696f7de579ddcc749d69626b8981d5c8128ebca00181afd983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/74/4.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/66735$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/66735$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/266192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aminoff, David</creatorcontrib><creatorcontrib>William F. Vorder Bruegge</creatorcontrib><creatorcontrib>Bell, William C.</creatorcontrib><creatorcontrib>Sarpolis, Keith</creatorcontrib><creatorcontrib>Williams, Revius</creatorcontrib><title>Role of Sialic Acid in Survival of Erythrocytes in the Circulation: Interaction of Neuraminidase-Treated and Untreated Erythrocytes with Spleen and Liver at the Cellular Level</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Sialidase (neuraminidase; acylneuraminyl hydrolase; EC 3.2.1.18)-treated erythrocytes obtained from different species are susceptible to rapid elimination from the circulation and are sequestered in the liver and spleen. The present studies were concerned with the mechanism of this clearance and how it may relate to the normal physiological process of removing senescent erythrocytes from the circulation. The results obtained indicate a preferential recognition of sialidase-treated as compared to normal erythrocytes by mononuclear spleen cells and Kupffer cells of the liver. This recognition manifests itself in both autologous and homologous systems by adhesion of the complementary cells in the form of rosettes, and as such could explain the removal of enzyme-treated erythrocytes from the circulation with their accumulation in liver and spleen. This phenomenon may represent a normal physiological mechanism for removal of senescent erythrocytes containing decreased sialic acid.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Blood</subject><subject>Chemical suspensions</subject><subject>Erythrocyte Aging</subject><subject>Erythrocytes</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - physiology</subject><subject>Hepatocytes</subject><subject>Kupffer cells</subject><subject>Kupffer Cells - physiology</subject><subject>Liver</subject><subject>Liver - physiology</subject><subject>Liver cells</subject><subject>Male</subject><subject>Neuraminidase - pharmacology</subject><subject>Rats</subject><subject>Sialic Acids - blood</subject><subject>Spleen</subject><subject>Spleen - physiology</subject><subject>Spleen cells</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAUhS3EayhsWSCQvOouwU6c2EFiUY0KVBqBxLRry2PfMK488dR2AvOr-IskZBi1G1bW9fnOfegg9JqSnBJevt93Kuac5SynVUEfoQUlDc1q1pDHaEFIwTPBCvYcvYjxlhDSVII8Q0-LuqZNsUC_v3sH2Ld4bZWzGl9oa7Dt8LoPgx2Um6TLcEjb4PUhQZy0tAW8tEH3TiXruw_4qksQlJ6Kif8KfVA721mjImTXAVQCg1Vn8E2XjtWDnj9t2uL13gF0f7GVHSBgleZJ4Nw4KeAVDOBeoietchFeHd8zdPPp8nr5JVt9-3y1vFhlmgmWMt3yDWlJKYjiranrpm65gYo3xmjNWWPGn6LeiEZQU2lBCwEbrQihgqrWNKI8Qx_nvvt-swOjYdxcObkPdqfCQXpl5UOls1v5ww-SlUQUdPSfH_3B3_UQk9zZqMdTVAe-j1KUDWVVyUcwn0EdfIwB2tMMSuQUsJwClpxJJqeAR8Pb-5ud8DnRUX53lCfbP_G-_fx_umx75xL8SiP4ZgZvY_LhRNY1L6vyDxmuxv0</recordid><startdate>19770401</startdate><enddate>19770401</enddate><creator>Aminoff, David</creator><creator>William F. Vorder Bruegge</creator><creator>Bell, William C.</creator><creator>Sarpolis, Keith</creator><creator>Williams, Revius</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19770401</creationdate><title>Role of Sialic Acid in Survival of Erythrocytes in the Circulation: Interaction of Neuraminidase-Treated and Untreated Erythrocytes with Spleen and Liver at the Cellular Level</title><author>Aminoff, David ; William F. Vorder Bruegge ; Bell, William C. ; Sarpolis, Keith ; Williams, Revius</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-cf7b0f0380a7fd6696f7de579ddcc749d69626b8981d5c8128ebca00181afd983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Blood</topic><topic>Chemical suspensions</topic><topic>Erythrocyte Aging</topic><topic>Erythrocytes</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - physiology</topic><topic>Hepatocytes</topic><topic>Kupffer cells</topic><topic>Kupffer Cells - physiology</topic><topic>Liver</topic><topic>Liver - physiology</topic><topic>Liver cells</topic><topic>Male</topic><topic>Neuraminidase - pharmacology</topic><topic>Rats</topic><topic>Sialic Acids - blood</topic><topic>Spleen</topic><topic>Spleen - physiology</topic><topic>Spleen cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aminoff, David</creatorcontrib><creatorcontrib>William F. Vorder Bruegge</creatorcontrib><creatorcontrib>Bell, William C.</creatorcontrib><creatorcontrib>Sarpolis, Keith</creatorcontrib><creatorcontrib>Williams, Revius</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aminoff, David</au><au>William F. 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The present studies were concerned with the mechanism of this clearance and how it may relate to the normal physiological process of removing senescent erythrocytes from the circulation. The results obtained indicate a preferential recognition of sialidase-treated as compared to normal erythrocytes by mononuclear spleen cells and Kupffer cells of the liver. This recognition manifests itself in both autologous and homologous systems by adhesion of the complementary cells in the form of rosettes, and as such could explain the removal of enzyme-treated erythrocytes from the circulation with their accumulation in liver and spleen. This phenomenon may represent a normal physiological mechanism for removal of senescent erythrocytes containing decreased sialic acid.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>266192</pmid><doi>10.1073/pnas.74.4.1521</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1977-04, Vol.74 (4), p.1521-1524 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biochemistry Blood Chemical suspensions Erythrocyte Aging Erythrocytes Erythrocytes - drug effects Erythrocytes - physiology Hepatocytes Kupffer cells Kupffer Cells - physiology Liver Liver - physiology Liver cells Male Neuraminidase - pharmacology Rats Sialic Acids - blood Spleen Spleen - physiology Spleen cells |
| title | Role of Sialic Acid in Survival of Erythrocytes in the Circulation: Interaction of Neuraminidase-Treated and Untreated Erythrocytes with Spleen and Liver at the Cellular Level |
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