Platelet Dysfunction Associated with Cardiopulmonary Bypass
The clinical significance and pathogenesis of the platelet dysfunction following cardiopulmonary bypass were studied in conjunction with the degree of functional impairment associated with the use of membrane and bubble oxygenators. Forty consecutive patients had the following tests preoperatively a...
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| Veröffentlicht in: | The Annals of thoracic surgery 1978-04, Vol.25 (4), p.298-305 |
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| container_title | The Annals of thoracic surgery |
| container_volume | 25 |
| creator | Friedenberg, William R. Myers, William O. Plotka, Edward D. Beathard, James N. Kummer, Daniel J. Gatlin, Patience F. Stoiber, Donald L. Ray, Jefferson F. Sautter, Richard D. |
| description | The clinical significance and pathogenesis of the platelet dysfunction following cardiopulmonary bypass were studied in conjunction with the degree of functional impairment associated with the use of membrane and bubble oxygenators. Forty consecutive patients had the following tests preoperatively and postoperatively: complete blood count (CBC), platelet count, prothrombin consumption time, bleeding time, prothrombin time, partial thromboplastin time, fibrinogen, euglobulin clot lysis, fibrin degradation products, and platelet aggregation tests. Six patients were given
14C-serotonin tests before and after operation, and preoperative and postoperative electron micrographs were made of the platelets of 3 patients. The amount of blood lost, the blood transfused, and plasma hemoglobin levels were also measured. Abnormal aggregation of platelets was found, with no difference between the membrane and bubble oxygenators. In vitro aggregation tests with protamine sulfate and hemoglobin solutions, as well as the
14C-serotonin studies and electron micrographs, suggest that platelets acquire storage pool deficiency and an abnormal membrane during cardiopulmonary bypass. |
| doi_str_mv | 10.1016/S0003-4975(10)63545-X |
| format | Article |
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14C-serotonin tests before and after operation, and preoperative and postoperative electron micrographs were made of the platelets of 3 patients. The amount of blood lost, the blood transfused, and plasma hemoglobin levels were also measured. Abnormal aggregation of platelets was found, with no difference between the membrane and bubble oxygenators. In vitro aggregation tests with protamine sulfate and hemoglobin solutions, as well as the
14C-serotonin studies and electron micrographs, suggest that platelets acquire storage pool deficiency and an abnormal membrane during cardiopulmonary bypass.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(10)63545-X</identifier><identifier>PMID: 345986</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Blood Coagulation Tests ; Blood Platelet Disorders - etiology ; Blood Platelets - ultrastructure ; Cardiac Surgical Procedures ; Cardiopulmonary Bypass - adverse effects ; Cardiopulmonary Bypass - instrumentation ; Clinical Trials as Topic ; Double-Blind Method ; Hematologic Tests ; Humans ; Platelet Aggregation ; Serotonin</subject><ispartof>The Annals of thoracic surgery, 1978-04, Vol.25 (4), p.298-305</ispartof><rights>1978 The Society of Thoracic Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-341305d94a7fcade47b3ea4ec249d4f8013f21b85d62d96980f7410952833cc73</citedby><cites>FETCH-LOGICAL-c394t-341305d94a7fcade47b3ea4ec249d4f8013f21b85d62d96980f7410952833cc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/345986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Friedenberg, William R.</creatorcontrib><creatorcontrib>Myers, William O.</creatorcontrib><creatorcontrib>Plotka, Edward D.</creatorcontrib><creatorcontrib>Beathard, James N.</creatorcontrib><creatorcontrib>Kummer, Daniel J.</creatorcontrib><creatorcontrib>Gatlin, Patience F.</creatorcontrib><creatorcontrib>Stoiber, Donald L.</creatorcontrib><creatorcontrib>Ray, Jefferson F.</creatorcontrib><creatorcontrib>Sautter, Richard D.</creatorcontrib><title>Platelet Dysfunction Associated with Cardiopulmonary Bypass</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>The clinical significance and pathogenesis of the platelet dysfunction following cardiopulmonary bypass were studied in conjunction with the degree of functional impairment associated with the use of membrane and bubble oxygenators. Forty consecutive patients had the following tests preoperatively and postoperatively: complete blood count (CBC), platelet count, prothrombin consumption time, bleeding time, prothrombin time, partial thromboplastin time, fibrinogen, euglobulin clot lysis, fibrin degradation products, and platelet aggregation tests. Six patients were given
14C-serotonin tests before and after operation, and preoperative and postoperative electron micrographs were made of the platelets of 3 patients. The amount of blood lost, the blood transfused, and plasma hemoglobin levels were also measured. Abnormal aggregation of platelets was found, with no difference between the membrane and bubble oxygenators. In vitro aggregation tests with protamine sulfate and hemoglobin solutions, as well as the
14C-serotonin studies and electron micrographs, suggest that platelets acquire storage pool deficiency and an abnormal membrane during cardiopulmonary bypass.</description><subject>Blood Coagulation Tests</subject><subject>Blood Platelet Disorders - etiology</subject><subject>Blood Platelets - ultrastructure</subject><subject>Cardiac Surgical Procedures</subject><subject>Cardiopulmonary Bypass - adverse effects</subject><subject>Cardiopulmonary Bypass - instrumentation</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Hematologic Tests</subject><subject>Humans</subject><subject>Platelet Aggregation</subject><subject>Serotonin</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLxDAQhYN4W1f_gUKfRB-qSZO0DT7Iul5hQUGFfQvZZIqR3kxaZf-9Wbvsq0_DzDkzJ_kQOiH4gmCSXr5ijGnMRMbPCD5PKWc8nm-hEeE8idOEi2002lj20YH3n6FNgryHdinjIk9H6OqlVB2U0EW3S1_0te5sU0cT7xttg2CiH9t9RFPljG3avqyaWrlldLNslfeHaKdQpYejdR2j9_u7t-ljPHt-eJpOZrGmgnUxZYRibgRTWaGVAZYtKCgGOmHCsCLHhBYJWeTcpIkRqchxkTGCBU9ySrXO6BidDndb13z14DtZWa-hLFUNTe9lTkVIoGkw8sGoXeO9g0K2zlbhwZJguWIm_5jJFZDV6I-ZnIe943VAv6jAbLYGSEG-HmQIn_y24KTXFmoNxjrQnTSN_SfgFxr0e0E</recordid><startdate>197804</startdate><enddate>197804</enddate><creator>Friedenberg, William R.</creator><creator>Myers, William O.</creator><creator>Plotka, Edward D.</creator><creator>Beathard, James N.</creator><creator>Kummer, Daniel J.</creator><creator>Gatlin, Patience F.</creator><creator>Stoiber, Donald L.</creator><creator>Ray, Jefferson F.</creator><creator>Sautter, Richard D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197804</creationdate><title>Platelet Dysfunction Associated with Cardiopulmonary Bypass</title><author>Friedenberg, William R. ; Myers, William O. ; Plotka, Edward D. ; Beathard, James N. ; Kummer, Daniel J. ; Gatlin, Patience F. ; Stoiber, Donald L. ; Ray, Jefferson F. ; Sautter, Richard D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-341305d94a7fcade47b3ea4ec249d4f8013f21b85d62d96980f7410952833cc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Blood Coagulation Tests</topic><topic>Blood Platelet Disorders - etiology</topic><topic>Blood Platelets - ultrastructure</topic><topic>Cardiac Surgical Procedures</topic><topic>Cardiopulmonary Bypass - adverse effects</topic><topic>Cardiopulmonary Bypass - instrumentation</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Hematologic Tests</topic><topic>Humans</topic><topic>Platelet Aggregation</topic><topic>Serotonin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Friedenberg, William R.</creatorcontrib><creatorcontrib>Myers, William O.</creatorcontrib><creatorcontrib>Plotka, Edward D.</creatorcontrib><creatorcontrib>Beathard, James N.</creatorcontrib><creatorcontrib>Kummer, Daniel J.</creatorcontrib><creatorcontrib>Gatlin, Patience F.</creatorcontrib><creatorcontrib>Stoiber, Donald L.</creatorcontrib><creatorcontrib>Ray, Jefferson F.</creatorcontrib><creatorcontrib>Sautter, Richard D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Friedenberg, William R.</au><au>Myers, William O.</au><au>Plotka, Edward D.</au><au>Beathard, James N.</au><au>Kummer, Daniel J.</au><au>Gatlin, Patience F.</au><au>Stoiber, Donald L.</au><au>Ray, Jefferson F.</au><au>Sautter, Richard D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet Dysfunction Associated with Cardiopulmonary Bypass</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1978-04</date><risdate>1978</risdate><volume>25</volume><issue>4</issue><spage>298</spage><epage>305</epage><pages>298-305</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>The clinical significance and pathogenesis of the platelet dysfunction following cardiopulmonary bypass were studied in conjunction with the degree of functional impairment associated with the use of membrane and bubble oxygenators. Forty consecutive patients had the following tests preoperatively and postoperatively: complete blood count (CBC), platelet count, prothrombin consumption time, bleeding time, prothrombin time, partial thromboplastin time, fibrinogen, euglobulin clot lysis, fibrin degradation products, and platelet aggregation tests. Six patients were given
14C-serotonin tests before and after operation, and preoperative and postoperative electron micrographs were made of the platelets of 3 patients. The amount of blood lost, the blood transfused, and plasma hemoglobin levels were also measured. Abnormal aggregation of platelets was found, with no difference between the membrane and bubble oxygenators. In vitro aggregation tests with protamine sulfate and hemoglobin solutions, as well as the
14C-serotonin studies and electron micrographs, suggest that platelets acquire storage pool deficiency and an abnormal membrane during cardiopulmonary bypass.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>345986</pmid><doi>10.1016/S0003-4975(10)63545-X</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Annals of thoracic surgery, 1978-04, Vol.25 (4), p.298-305 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Blood Coagulation Tests Blood Platelet Disorders - etiology Blood Platelets - ultrastructure Cardiac Surgical Procedures Cardiopulmonary Bypass - adverse effects Cardiopulmonary Bypass - instrumentation Clinical Trials as Topic Double-Blind Method Hematologic Tests Humans Platelet Aggregation Serotonin |
| title | Platelet Dysfunction Associated with Cardiopulmonary Bypass |
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