Chromosome abnormalities and clinical and morphologic manifestations of chronic myeloid leukemia
Forty cases of chronic myeloid leukemia (CML) were studied and subgroups of cases with similar chromosomal abnormalities in terminal stage were defined. Certain correlations were observed between the type of chromosomal changes, and clinical and morphologic manifestations of the disease: (1) It seem...
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| Veröffentlicht in: | Human genetics 1978-01, Vol.41 (2), p.143-156 |
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| creator | Prigogina, E L Fleischman, E W Volkova, M A Frenkel, M A |
| description | Forty cases of chronic myeloid leukemia (CML) were studied and subgroups of cases with similar chromosomal abnormalities in terminal stage were defined. Certain correlations were observed between the type of chromosomal changes, and clinical and morphologic manifestations of the disease: (1) It seems that, in cases without any karyotype changes other than translocation (9;22), the terminal stage is longer and milder than in cases with additional chromosomal abnormalities; (2) cases with marker i(17q) are clinically and morphologically rather uniform and are characterized by distinct signs of myeloid differentiation of blast cells, absent in other cases; (3) in cases with various atypical chromosomal abnormalities, the course of the terminal stage is the most rapid and grave. The blast cells differ from myeloblasts and resemble lymphoid elements. |
| doi_str_mv | 10.1007/BF00273096 |
| format | Article |
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Certain correlations were observed between the type of chromosomal changes, and clinical and morphologic manifestations of the disease: (1) It seems that, in cases without any karyotype changes other than translocation (9;22), the terminal stage is longer and milder than in cases with additional chromosomal abnormalities; (2) cases with marker i(17q) are clinically and morphologically rather uniform and are characterized by distinct signs of myeloid differentiation of blast cells, absent in other cases; (3) in cases with various atypical chromosomal abnormalities, the course of the terminal stage is the most rapid and grave. 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Certain correlations were observed between the type of chromosomal changes, and clinical and morphologic manifestations of the disease: (1) It seems that, in cases without any karyotype changes other than translocation (9;22), the terminal stage is longer and milder than in cases with additional chromosomal abnormalities; (2) cases with marker i(17q) are clinically and morphologically rather uniform and are characterized by distinct signs of myeloid differentiation of blast cells, absent in other cases; (3) in cases with various atypical chromosomal abnormalities, the course of the terminal stage is the most rapid and grave. The blast cells differ from myeloblasts and resemble lymphoid elements.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, 21-22 and Y</subject><subject>Chromosomes, Human, 6-12 and X</subject><subject>Female</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemia, Myeloid - complications</subject><subject>Leukemia, Myeloid - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Time Factors</subject><subject>Translocation, Genetic</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi3EVykszAyZGJACZzuxk5FWFJAqscAc_BVqsONiJ0P_PSmtYDq9ukev7h6ELjHcYgB-N1sAEE6hZgdoggtKckyAHqIJ0AJyxjE_RWcpfQLgsiblCToe6ZLDBL3PVzH4kII3mZBdiF4421uTMtHpTDnbWSXcb_AhrlfBhQ-rMi8625rUi96GLmWhzdTY0203G-OC1Zkzw5fxVpyjo1a4ZC72c4reFg-v86d8-fL4PL9f5opUuM-1FDWWhoOpqtYwpQvBS1ZoaWTFMCaak_FDTUASoaEqeMUkYyBZraHWtKVTdL3rXcfwPYynNd4mZZwTnQlDaipaY0IKGMGbHahiSCmatllH60XcNBiarc3m3-YIX-1bB-mN_kN3-ugP-UpwhA</recordid><startdate>19780101</startdate><enddate>19780101</enddate><creator>Prigogina, E L</creator><creator>Fleischman, E W</creator><creator>Volkova, M A</creator><creator>Frenkel, M A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780101</creationdate><title>Chromosome abnormalities and clinical and morphologic manifestations of chronic myeloid leukemia</title><author>Prigogina, E L ; Fleischman, E W ; Volkova, M A ; Frenkel, M A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-dba91be70e88fe6cd4a7564dbeb86112d72027d20b2ad084786b660b69d09d3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, 21-22 and Y</topic><topic>Chromosomes, Human, 6-12 and X</topic><topic>Female</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leukemia, Myeloid - complications</topic><topic>Leukemia, Myeloid - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Time Factors</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prigogina, E L</creatorcontrib><creatorcontrib>Fleischman, E W</creatorcontrib><creatorcontrib>Volkova, M A</creatorcontrib><creatorcontrib>Frenkel, M A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prigogina, E L</au><au>Fleischman, E W</au><au>Volkova, M A</au><au>Frenkel, M A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosome abnormalities and clinical and morphologic manifestations of chronic myeloid leukemia</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>1978-01-01</date><risdate>1978</risdate><volume>41</volume><issue>2</issue><spage>143</spage><epage>156</epage><pages>143-156</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><abstract>Forty cases of chronic myeloid leukemia (CML) were studied and subgroups of cases with similar chromosomal abnormalities in terminal stage were defined. Certain correlations were observed between the type of chromosomal changes, and clinical and morphologic manifestations of the disease: (1) It seems that, in cases without any karyotype changes other than translocation (9;22), the terminal stage is longer and milder than in cases with additional chromosomal abnormalities; (2) cases with marker i(17q) are clinically and morphologically rather uniform and are characterized by distinct signs of myeloid differentiation of blast cells, absent in other cases; (3) in cases with various atypical chromosomal abnormalities, the course of the terminal stage is the most rapid and grave. The blast cells differ from myeloblasts and resemble lymphoid elements.</abstract><cop>Germany</cop><pmid>273570</pmid><doi>10.1007/BF00273096</doi><tpages>14</tpages></addata></record> |
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| ispartof | Human genetics, 1978-01, Vol.41 (2), p.143-156 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Aged Child Child, Preschool Chromosome Aberrations Chromosomes, Human, 21-22 and Y Chromosomes, Human, 6-12 and X Female Humans Karyotyping Leukemia, Myeloid - complications Leukemia, Myeloid - genetics Male Middle Aged Time Factors Translocation, Genetic |
| title | Chromosome abnormalities and clinical and morphologic manifestations of chronic myeloid leukemia |
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