Effects of short-term administration of maleic hydrazide or hydrazine on rat hepatic microsomal enzymes

The herbicide maleic hydrazide (MH), in amounts greatly exceeding its residue level in foods, had no apparent effect on the hepatic microsomal enzyme system of Fischer rats. In vivo, up to 1 g/kg of MH did not affect hexobarbital sleep times (HST) and in vitro, 2 g/kg of the sodium salt of MH altere...

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Veröffentlicht in:	Toxicology and applied pharmacology 1978-02, Vol.43 (2), p.287-292
Hauptverfasser:	Akin, Frank J., Norred, William P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytochrome P-450 Enzyme System - metabolism Cytochromes - metabolism Hexobarbital - pharmacology Hydrazines - pharmacology In Vitro Techniques Maleic Hydrazide - pharmacology Microsomes, Liver - drug effects Microsomes, Liver - enzymology Pyridazines - pharmacology Rats Sleep - drug effects Time Factors
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