Tyramine-like Effect of Cyclocytidine (2, 2'-Anhydro-1-beta-Arabinofuranosylcytosine Hydrochloride), an Antineoplastic Agent
Since cyclocytidine (2, 2'-anhydro-1-beta-arabinofuranosyleytosine hydrochloride) was introduced as an antineoplastic agent for the treatment of lymphatic leukemia, sinus acceleration and an increase in systemic blood pressure has been reported as its systemic effects in the clinical cases. The...
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| Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 1978, Vol.124(1), pp.83-90 |
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| container_title | The Tohoku Journal of Experimental Medicine |
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| creator | OGURO, KATSUNORI HASHIMOTO, KOROKU |
| description | Since cyclocytidine (2, 2'-anhydro-1-beta-arabinofuranosyleytosine hydrochloride) was introduced as an antineoplastic agent for the treatment of lymphatic leukemia, sinus acceleration and an increase in systemic blood pressure has been reported as its systemic effects in the clinical cases. These cardiovascular effects of cyclocytidine were observed also in anesthetized dogs, but not in reserpine-pretreated animals. Increases in heart rate and in systemic blood pressure were prevented by propranolol and phentolamine, respectively. The mechanism of these sympathomimetic effects was further analysed in the excised, blood-perfused canine sinoatrial node and papillary muscle preparations with a support dog. Positive chronotropic and inotropic responses to cyclocytidine were abolished by desipramine, propranolol, and pretreatment with reserpine but not by tetrodotoxin and hexamethonium. The tyramine-like actions of cyclocytidine at adrenergic neuronal terminals were discussed in conjunction with the uptake mechanism of the drug into the tumor cells. |
| doi_str_mv | 10.1620/tjem.124.83 |
| format | Article |
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These cardiovascular effects of cyclocytidine were observed also in anesthetized dogs, but not in reserpine-pretreated animals. Increases in heart rate and in systemic blood pressure were prevented by propranolol and phentolamine, respectively. The mechanism of these sympathomimetic effects was further analysed in the excised, blood-perfused canine sinoatrial node and papillary muscle preparations with a support dog. Positive chronotropic and inotropic responses to cyclocytidine were abolished by desipramine, propranolol, and pretreatment with reserpine but not by tetrodotoxin and hexamethonium. The tyramine-like actions of cyclocytidine at adrenergic neuronal terminals were discussed in conjunction with the uptake mechanism of the drug into the tumor cells.</description><identifier>ISSN: 0040-8727</identifier><identifier>EISSN: 1349-3329</identifier><identifier>DOI: 10.1620/tjem.124.83</identifier><identifier>PMID: 76345</identifier><language>eng</language><publisher>Japan: Tohoku University Medical Press</publisher><subject>Ancitabine - metabolism ; Ancitabine - pharmacology ; Animals ; Blood Pressure - drug effects ; blood-perfused preparations of canine sinoatrial node and papillary muscle ; cyclocytidine ; Cytarabine - analogs & derivatives ; Cytarabine - pharmacology ; Dogs ; Female ; Heart Rate - drug effects ; In Vitro Techniques ; Male ; Papillary Muscles - drug effects ; positive chronotropic and inotropic effects ; Sinoatrial Node - drug effects ; Sympathomimetics ; Tyramine - pharmacology ; tyramine-like sympathomimetic effect</subject><ispartof>The Tohoku Journal of Experimental Medicine, 1978, Vol.124(1), pp.83-90</ispartof><rights>Tohoku University Medical Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/76345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OGURO, KATSUNORI</creatorcontrib><creatorcontrib>HASHIMOTO, KOROKU</creatorcontrib><title>Tyramine-like Effect of Cyclocytidine (2, 2'-Anhydro-1-beta-Arabinofuranosylcytosine Hydrochloride), an Antineoplastic Agent</title><title>The Tohoku Journal of Experimental Medicine</title><addtitle>Tohoku J. Exp. Med.</addtitle><description>Since cyclocytidine (2, 2'-anhydro-1-beta-arabinofuranosyleytosine hydrochloride) was introduced as an antineoplastic agent for the treatment of lymphatic leukemia, sinus acceleration and an increase in systemic blood pressure has been reported as its systemic effects in the clinical cases. These cardiovascular effects of cyclocytidine were observed also in anesthetized dogs, but not in reserpine-pretreated animals. Increases in heart rate and in systemic blood pressure were prevented by propranolol and phentolamine, respectively. The mechanism of these sympathomimetic effects was further analysed in the excised, blood-perfused canine sinoatrial node and papillary muscle preparations with a support dog. Positive chronotropic and inotropic responses to cyclocytidine were abolished by desipramine, propranolol, and pretreatment with reserpine but not by tetrodotoxin and hexamethonium. The tyramine-like actions of cyclocytidine at adrenergic neuronal terminals were discussed in conjunction with the uptake mechanism of the drug into the tumor cells.</description><subject>Ancitabine - metabolism</subject><subject>Ancitabine - pharmacology</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>blood-perfused preparations of canine sinoatrial node and papillary muscle</subject><subject>cyclocytidine</subject><subject>Cytarabine - analogs & derivatives</subject><subject>Cytarabine - pharmacology</subject><subject>Dogs</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Papillary Muscles - drug effects</subject><subject>positive chronotropic and inotropic effects</subject><subject>Sinoatrial Node - drug effects</subject><subject>Sympathomimetics</subject><subject>Tyramine - pharmacology</subject><subject>tyramine-like sympathomimetic effect</subject><issn>0040-8727</issn><issn>1349-3329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1v2zAURYkiQeumnTp20ZQ0SOjyy6I0CoaTFAjQJZ0FknqM5VKiS9KDgP74ULHh5XE4hxfvXYS-UbKkJSM_0w6GJWViWfEPaEG5qDHnrL5AC0IEwZVk8hP6HOOOEC6ILD-iS1lysVqg_y9TUEM_Anb9Xyg21oJJhbfFejLOmyn1XYbFD3ZfsBvcjNupCx5TrCEp3ASl-9HbQ1Cjj5PLuo-z_jRbZut86Du4vS_UWDRjysTvnYqpN0XzCmP6gi6tchG-nt4r9Odh87J-ws-_H3-tm2dshCg5ZlpYXgttS9txXtaMAlGlYR3RtdRgZUVkBWplGYGqZrBSFqTQlZLGasMYv0LXx9x98P8OEFM79NGAcypvdIhtxWuykoRn8e4omuBjDGDbfegHFaaWknZuup2bbnPT-U-2v59iD3qA7uy-V5vp5kh3MalXOFMV8v0O3pNonSPnNHqaFT9zs1WhhZG_AdAQk3U</recordid><startdate>1978</startdate><enddate>1978</enddate><creator>OGURO, KATSUNORI</creator><creator>HASHIMOTO, KOROKU</creator><general>Tohoku University Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1978</creationdate><title>Tyramine-like Effect of Cyclocytidine (2, 2'-Anhydro-1-beta-Arabinofuranosylcytosine Hydrochloride), an Antineoplastic Agent</title><author>OGURO, KATSUNORI ; HASHIMOTO, KOROKU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4463-2b4f394bf6fd336921e0a6c2d0b97bef78078ea5f20e892e5afe74b8a7cfbc223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Ancitabine - metabolism</topic><topic>Ancitabine - pharmacology</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>blood-perfused preparations of canine sinoatrial node and papillary muscle</topic><topic>cyclocytidine</topic><topic>Cytarabine - analogs & derivatives</topic><topic>Cytarabine - pharmacology</topic><topic>Dogs</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Papillary Muscles - drug effects</topic><topic>positive chronotropic and inotropic effects</topic><topic>Sinoatrial Node - drug effects</topic><topic>Sympathomimetics</topic><topic>Tyramine - pharmacology</topic><topic>tyramine-like sympathomimetic effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OGURO, KATSUNORI</creatorcontrib><creatorcontrib>HASHIMOTO, KOROKU</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Tohoku Journal of Experimental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OGURO, KATSUNORI</au><au>HASHIMOTO, KOROKU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tyramine-like Effect of Cyclocytidine (2, 2'-Anhydro-1-beta-Arabinofuranosylcytosine Hydrochloride), an Antineoplastic Agent</atitle><jtitle>The Tohoku Journal of Experimental Medicine</jtitle><addtitle>Tohoku J. Exp. Med.</addtitle><date>1978</date><risdate>1978</risdate><volume>124</volume><issue>1</issue><spage>83</spage><epage>90</epage><pages>83-90</pages><issn>0040-8727</issn><eissn>1349-3329</eissn><abstract>Since cyclocytidine (2, 2'-anhydro-1-beta-arabinofuranosyleytosine hydrochloride) was introduced as an antineoplastic agent for the treatment of lymphatic leukemia, sinus acceleration and an increase in systemic blood pressure has been reported as its systemic effects in the clinical cases. These cardiovascular effects of cyclocytidine were observed also in anesthetized dogs, but not in reserpine-pretreated animals. Increases in heart rate and in systemic blood pressure were prevented by propranolol and phentolamine, respectively. The mechanism of these sympathomimetic effects was further analysed in the excised, blood-perfused canine sinoatrial node and papillary muscle preparations with a support dog. Positive chronotropic and inotropic responses to cyclocytidine were abolished by desipramine, propranolol, and pretreatment with reserpine but not by tetrodotoxin and hexamethonium. The tyramine-like actions of cyclocytidine at adrenergic neuronal terminals were discussed in conjunction with the uptake mechanism of the drug into the tumor cells.</abstract><cop>Japan</cop><pub>Tohoku University Medical Press</pub><pmid>76345</pmid><doi>10.1620/tjem.124.83</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Tohoku Journal of Experimental Medicine, 1978, Vol.124(1), pp.83-90 |
| issn | 0040-8727 1349-3329 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Ancitabine - metabolism Ancitabine - pharmacology Animals Blood Pressure - drug effects blood-perfused preparations of canine sinoatrial node and papillary muscle cyclocytidine Cytarabine - analogs & derivatives Cytarabine - pharmacology Dogs Female Heart Rate - drug effects In Vitro Techniques Male Papillary Muscles - drug effects positive chronotropic and inotropic effects Sinoatrial Node - drug effects Sympathomimetics Tyramine - pharmacology tyramine-like sympathomimetic effect |
| title | Tyramine-like Effect of Cyclocytidine (2, 2'-Anhydro-1-beta-Arabinofuranosylcytosine Hydrochloride), an Antineoplastic Agent |
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