Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency
THE secretion of prolactin, a pituitary hormone, is regulated by inhibitory and stimulatory influences from the hypothalamus. The primary influence is tonic inhibitory 1 . Dopamine, a neurotransmitter, has a major direct and/or indirect role in mediating this inhibition upon the prolactin cells in t...
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Veröffentlicht in: | Nature (London) 1977-04, Vol.266 (5603), p.639-640 |
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description | THE secretion of prolactin, a pituitary hormone, is regulated by inhibitory and stimulatory influences from the hypothalamus. The primary influence is tonic inhibitory
1
. Dopamine, a neurotransmitter, has a major direct and/or indirect role in mediating this inhibition upon the prolactin cells in the pituitary gland. This is documented by studies
in vitro
1
,
in vivo
2
and in man
3
. All known neuroleptic, antischizophrenic drugs share one characteristic—they block dopaminergic transmission
4–7
. This action is hypothesised to be associated with their antischizophrenic effects (dopamine hypothesis)
3,9
. Dopaminergic blockade is, very likely, also the primary mechanism of neuroleptics when inducing prolactin release via disinhibition
1,10
. There is no evidence that neuroleptics release prolactin via stimulatory influences. We believe the prolactin response to neuroleptic drugs to be a valid and reliable model of dopaminergic blockade in man (Langer
et al
., unpublished). Intesting the dopamine hypothesis of antischizophrenic drug action in man we postulated that comparing drug effects after acute intramuscular administration, a high correlation between prolactin releasing and antischizophrenic potencies of neuroleptics would be found. |
doi_str_mv | 10.1038/266639a0 |
format | Article |
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1
. Dopamine, a neurotransmitter, has a major direct and/or indirect role in mediating this inhibition upon the prolactin cells in the pituitary gland. This is documented by studies
in vitro
1
,
in vivo
2
and in man
3
. All known neuroleptic, antischizophrenic drugs share one characteristic—they block dopaminergic transmission
4–7
. This action is hypothesised to be associated with their antischizophrenic effects (dopamine hypothesis)
3,9
. Dopaminergic blockade is, very likely, also the primary mechanism of neuroleptics when inducing prolactin release via disinhibition
1,10
. There is no evidence that neuroleptics release prolactin via stimulatory influences. We believe the prolactin response to neuroleptic drugs to be a valid and reliable model of dopaminergic blockade in man (Langer
et al
., unpublished). Intesting the dopamine hypothesis of antischizophrenic drug action in man we postulated that comparing drug effects after acute intramuscular administration, a high correlation between prolactin releasing and antischizophrenic potencies of neuroleptics would be found.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/266639a0</identifier><identifier>PMID: 193037</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Chlorpromazine - pharmacology ; Dopamine - metabolism ; Dose-Response Relationship, Drug ; Fluphenazine - pharmacology ; Haloperidol - pharmacology ; Humanities and Social Sciences ; Humans ; letter ; Male ; multidisciplinary ; Perphenazine - pharmacology ; Prochlorperazine - pharmacology ; Prolactin - metabolism ; Schizophrenia - drug therapy ; Science ; Science (multidisciplinary) ; Synaptic Transmission - drug effects ; Thiothixene - pharmacology ; Tranquilizing Agents - pharmacology ; Trifluoperazine - pharmacology</subject><ispartof>Nature (London), 1977-04, Vol.266 (5603), p.639-640</ispartof><rights>Springer Nature Limited 1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2490-495935f2a29734cdfda4ceeed48765c686dc55264b00e75bebaf69617046b7d23</citedby><cites>FETCH-LOGICAL-c2490-495935f2a29734cdfda4ceeed48765c686dc55264b00e75bebaf69617046b7d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/193037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LANGER, GERHARD</creatorcontrib><creatorcontrib>SACHAR, EDWARD J</creatorcontrib><creatorcontrib>GRUEN, PETER H</creatorcontrib><creatorcontrib>HALPERN, FRIEDA S</creatorcontrib><title>Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THE secretion of prolactin, a pituitary hormone, is regulated by inhibitory and stimulatory influences from the hypothalamus. The primary influence is tonic inhibitory
1
. Dopamine, a neurotransmitter, has a major direct and/or indirect role in mediating this inhibition upon the prolactin cells in the pituitary gland. This is documented by studies
in vitro
1
,
in vivo
2
and in man
3
. All known neuroleptic, antischizophrenic drugs share one characteristic—they block dopaminergic transmission
4–7
. This action is hypothesised to be associated with their antischizophrenic effects (dopamine hypothesis)
3,9
. Dopaminergic blockade is, very likely, also the primary mechanism of neuroleptics when inducing prolactin release via disinhibition
1,10
. There is no evidence that neuroleptics release prolactin via stimulatory influences. We believe the prolactin response to neuroleptic drugs to be a valid and reliable model of dopaminergic blockade in man (Langer
et al
., unpublished). Intesting the dopamine hypothesis of antischizophrenic drug action in man we postulated that comparing drug effects after acute intramuscular administration, a high correlation between prolactin releasing and antischizophrenic potencies of neuroleptics would be found.</description><subject>Chlorpromazine - pharmacology</subject><subject>Dopamine - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fluphenazine - pharmacology</subject><subject>Haloperidol - pharmacology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Perphenazine - pharmacology</subject><subject>Prochlorperazine - pharmacology</subject><subject>Prolactin - metabolism</subject><subject>Schizophrenia - drug therapy</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Synaptic Transmission - drug effects</subject><subject>Thiothixene - pharmacology</subject><subject>Tranquilizing Agents - pharmacology</subject><subject>Trifluoperazine - pharmacology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LxDAURYP4NY6CP0CkK9FFNW3SpFnKoI4w4EZxWdL0daZDm9QkRcZfb7Q6bly9xT0c3r0InSb4OsEkv0kZY0RIvIMmCeUspiznu2iCcZrHOCfsEB05t8YYZwmnB2g_EQQTPkGv86GTOuqtaaXyjY4suN5oBy7yJtIwhAB636iossPSRcpYC630EL03fhVJ7RunVs2H6VcWdMB640GrzTHaq2Xr4OTnTtHL_d3zbB4vnh4eZ7eLWKVU4JiKTJCsTmUqOKGqqitJFQBUNOcsUyxnlcqylNESY-BZCaWsmWAJx5SVvErJFF2M3tDgbQDniy48BG0rNZjBFTnJBRUsC-DlCCprnLNQF71tOmk3RYKLrwmL3wkDevbjHMoOqj_we7MQX42xC4Fegi3WZrA6tPxPdT6yWvrBwla1BT4BwUeEQA</recordid><startdate>19770414</startdate><enddate>19770414</enddate><creator>LANGER, GERHARD</creator><creator>SACHAR, EDWARD J</creator><creator>GRUEN, PETER H</creator><creator>HALPERN, FRIEDA S</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19770414</creationdate><title>Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency</title><author>LANGER, GERHARD ; SACHAR, EDWARD J ; GRUEN, PETER H ; HALPERN, FRIEDA S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2490-495935f2a29734cdfda4ceeed48765c686dc55264b00e75bebaf69617046b7d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Chlorpromazine - pharmacology</topic><topic>Dopamine - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fluphenazine - pharmacology</topic><topic>Haloperidol - pharmacology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Perphenazine - pharmacology</topic><topic>Prochlorperazine - pharmacology</topic><topic>Prolactin - metabolism</topic><topic>Schizophrenia - drug therapy</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Synaptic Transmission - drug effects</topic><topic>Thiothixene - pharmacology</topic><topic>Tranquilizing Agents - pharmacology</topic><topic>Trifluoperazine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LANGER, GERHARD</creatorcontrib><creatorcontrib>SACHAR, EDWARD J</creatorcontrib><creatorcontrib>GRUEN, PETER H</creatorcontrib><creatorcontrib>HALPERN, FRIEDA S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LANGER, GERHARD</au><au>SACHAR, EDWARD J</au><au>GRUEN, PETER H</au><au>HALPERN, FRIEDA S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1977-04-14</date><risdate>1977</risdate><volume>266</volume><issue>5603</issue><spage>639</spage><epage>640</epage><pages>639-640</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>THE secretion of prolactin, a pituitary hormone, is regulated by inhibitory and stimulatory influences from the hypothalamus. The primary influence is tonic inhibitory
1
. Dopamine, a neurotransmitter, has a major direct and/or indirect role in mediating this inhibition upon the prolactin cells in the pituitary gland. This is documented by studies
in vitro
1
,
in vivo
2
and in man
3
. All known neuroleptic, antischizophrenic drugs share one characteristic—they block dopaminergic transmission
4–7
. This action is hypothesised to be associated with their antischizophrenic effects (dopamine hypothesis)
3,9
. Dopaminergic blockade is, very likely, also the primary mechanism of neuroleptics when inducing prolactin release via disinhibition
1,10
. There is no evidence that neuroleptics release prolactin via stimulatory influences. We believe the prolactin response to neuroleptic drugs to be a valid and reliable model of dopaminergic blockade in man (Langer
et al
., unpublished). Intesting the dopamine hypothesis of antischizophrenic drug action in man we postulated that comparing drug effects after acute intramuscular administration, a high correlation between prolactin releasing and antischizophrenic potencies of neuroleptics would be found.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>193037</pmid><doi>10.1038/266639a0</doi><tpages>2</tpages></addata></record> |
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subjects | Chlorpromazine - pharmacology Dopamine - metabolism Dose-Response Relationship, Drug Fluphenazine - pharmacology Haloperidol - pharmacology Humanities and Social Sciences Humans letter Male multidisciplinary Perphenazine - pharmacology Prochlorperazine - pharmacology Prolactin - metabolism Schizophrenia - drug therapy Science Science (multidisciplinary) Synaptic Transmission - drug effects Thiothixene - pharmacology Tranquilizing Agents - pharmacology Trifluoperazine - pharmacology |
title | Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency |
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