Changes in the sarcolemma of the hypothyroid heart

Sarcolemmal membranes prepared from the hearts of thyroidectomised sheep showed a fall of more than 90% in both 5′-nucleotidase activity and the number of β-adrenergic receptor sites. A fall of more than 60% in both Na ++K +ATPase and adenyl cyclase activities also occurred. Either long-term or shor...

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Veröffentlicht in:	Biochemical and biophysical research communications 1978-02, Vol.80 (4), p.715-721
Hauptverfasser:	Smith, R.M., Osborne-White, W.S., King, R.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adenylyl Cyclases - metabolism Animals Kinetics Male Membranes - metabolism Myocardium - metabolism Nucleotidases - metabolism Receptors, Adrenergic, beta - metabolism Sarcolemma - metabolism Sheep Thyroidectomy
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Zusammenfassung:	Sarcolemmal membranes prepared from the hearts of thyroidectomised sheep showed a fall of more than 90% in both 5′-nucleotidase activity and the number of β-adrenergic receptor sites. A fall of more than 60% in both Na ++K +ATPase and adenyl cyclase activities also occurred. Either long-term or short-term treatment with thyroid hormones brought about concerted recovery of these pairs of sarcolemmal functions.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(78)91303-7