The influence of anxiety and pain sensitivity on experimental pain in man
A study was made of a number of factors that might be responsible for the unreliable results obtained in experimentally induced pain in man. In a randomised, double-blind, cross-over study on 32 healthy, male volunteers, the ischaemic pain test [14] and several psychological tests were performed. Th...
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| Veröffentlicht in: | Pain (Amsterdam) 1978-01, Vol.4 (3), p.253-263 |
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| container_title | Pain (Amsterdam) |
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| creator | Von Graffenried, Beat Adler, Rolf Abt, Klaus Nüesch, Erich Spiegel, René |
| description | A study was made of a number of factors that might be responsible for the unreliable results obtained in experimentally induced pain in man.
In a randomised, double-blind, cross-over study on 32 healthy, male volunteers, the ischaemic pain test [14] and several psychological tests were performed. The influence of the following factors on the pain test results were examined
1.
(a) ingestion of single, oral doses of 1000 mg aspirin (ASA) and placebo
2.
(b) practice effect
3.
(c) initial pain sensitivity
4.
(d) anxiety, coping behaviour, attitude to the experiment and personality factors.
The analgesic activity of ASA could not be demonstrated. An interaction between primary pain sensitivity and the sequence of drug administration was found. Furthermore, anxiety had a marked influence on the test results. Using experimental pain models reliable results are not to be expected as anxiety fluctuates intra- and interindividually in an unpredictable and uncontrollable manner. |
| doi_str_mv | 10.1016/0304-3959(77)90137-3 |
| format | Article |
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In a randomised, double-blind, cross-over study on 32 healthy, male volunteers, the ischaemic pain test [14] and several psychological tests were performed. The influence of the following factors on the pain test results were examined
1.
(a) ingestion of single, oral doses of 1000 mg aspirin (ASA) and placebo
2.
(b) practice effect
3.
(c) initial pain sensitivity
4.
(d) anxiety, coping behaviour, attitude to the experiment and personality factors.
The analgesic activity of ASA could not be demonstrated. An interaction between primary pain sensitivity and the sequence of drug administration was found. Furthermore, anxiety had a marked influence on the test results. Using experimental pain models reliable results are not to be expected as anxiety fluctuates intra- and interindividually in an unpredictable and uncontrollable manner.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1016/0304-3959(77)90137-3</identifier><identifier>PMID: 345198</identifier><language>eng</language><publisher>United States: Elsevier B.V</publisher><subject>Adaptation, Psychological ; Adult ; Anxiety - psychology ; Aspirin - therapeutic use ; Attitude ; Clinical Trials as Topic ; Double-Blind Method ; Humans ; Male ; Pain - drug therapy ; Pain - psychology ; Practice, Psychological ; Psychological Tests</subject><ispartof>Pain (Amsterdam), 1978-01, Vol.4 (3), p.253-263</ispartof><rights>1977</rights><rights>Lippincott-Raven Publishers.Copyright © Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4555-ce82d5a3d576141043a1d88b5a333dea16744d5483aa92dad4644ac3be18208b3</citedby><cites>FETCH-LOGICAL-c4555-ce82d5a3d576141043a1d88b5a333dea16744d5483aa92dad4644ac3be18208b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3959(77)90137-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/345198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Von Graffenried, Beat</creatorcontrib><creatorcontrib>Adler, Rolf</creatorcontrib><creatorcontrib>Abt, Klaus</creatorcontrib><creatorcontrib>Nüesch, Erich</creatorcontrib><creatorcontrib>Spiegel, René</creatorcontrib><title>The influence of anxiety and pain sensitivity on experimental pain in man</title><title>Pain (Amsterdam)</title><addtitle>Pain</addtitle><description>A study was made of a number of factors that might be responsible for the unreliable results obtained in experimentally induced pain in man.
In a randomised, double-blind, cross-over study on 32 healthy, male volunteers, the ischaemic pain test [14] and several psychological tests were performed. The influence of the following factors on the pain test results were examined
1.
(a) ingestion of single, oral doses of 1000 mg aspirin (ASA) and placebo
2.
(b) practice effect
3.
(c) initial pain sensitivity
4.
(d) anxiety, coping behaviour, attitude to the experiment and personality factors.
The analgesic activity of ASA could not be demonstrated. An interaction between primary pain sensitivity and the sequence of drug administration was found. Furthermore, anxiety had a marked influence on the test results. Using experimental pain models reliable results are not to be expected as anxiety fluctuates intra- and interindividually in an unpredictable and uncontrollable manner.</description><subject>Adaptation, Psychological</subject><subject>Adult</subject><subject>Anxiety - psychology</subject><subject>Aspirin - therapeutic use</subject><subject>Attitude</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Male</subject><subject>Pain - drug therapy</subject><subject>Pain - psychology</subject><subject>Practice, Psychological</subject><subject>Psychological Tests</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElLxEAQhRtxG5d_4CEn0UO09-UiiLiB4EXPTU-6hmnNdMZ0Muq_t2OG8SYUVVTx3qP4EDoh-IJgIi8xw7xkRpgzpc4NJkyVbAtNiFa0lJKybTTZSPbRQUpvGGNKqdlDu4wLYvQEPb7MoQhxVvcQKyiaWeHiV4DuO09fLF2IRYKYQhdWIR-bWMDXEtqwgNi5ehTkWrh4hHZmrk5wvJ6H6PXu9uXmoXx6vn-8uX4qKy6EKCvQ1AvHvFCScII5c8RrPc0nxjw4IhXnXnDNnDPUO88l565iUyCaYj1lh-h0zF22zUcPqbOLkCqoaxeh6ZPVTBsiMc1CPgqrtkmphZld5r9d-20JtgNAO9CxAx2rlP0FaFm2nazz--kC_MY0EvtL_WzqDtr0Xvef0No5uLqb2wwYS2ZkSYxSJC-kzE2IbLsabZDRrEJ2pCoMyH1ooeqsb8L_b_0Ab0eOMw</recordid><startdate>19780101</startdate><enddate>19780101</enddate><creator>Von Graffenried, Beat</creator><creator>Adler, Rolf</creator><creator>Abt, Klaus</creator><creator>Nüesch, Erich</creator><creator>Spiegel, René</creator><general>Elsevier B.V</general><general>Lippincott-Raven Publishers.Copyright Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780101</creationdate><title>The influence of anxiety and pain sensitivity on experimental pain in man</title><author>Von Graffenried, Beat ; Adler, Rolf ; Abt, Klaus ; Nüesch, Erich ; Spiegel, René</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4555-ce82d5a3d576141043a1d88b5a333dea16744d5483aa92dad4644ac3be18208b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adaptation, Psychological</topic><topic>Adult</topic><topic>Anxiety - psychology</topic><topic>Aspirin - therapeutic use</topic><topic>Attitude</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Humans</topic><topic>Male</topic><topic>Pain - drug therapy</topic><topic>Pain - psychology</topic><topic>Practice, Psychological</topic><topic>Psychological Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Von Graffenried, Beat</creatorcontrib><creatorcontrib>Adler, Rolf</creatorcontrib><creatorcontrib>Abt, Klaus</creatorcontrib><creatorcontrib>Nüesch, Erich</creatorcontrib><creatorcontrib>Spiegel, René</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Von Graffenried, Beat</au><au>Adler, Rolf</au><au>Abt, Klaus</au><au>Nüesch, Erich</au><au>Spiegel, René</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of anxiety and pain sensitivity on experimental pain in man</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>1978-01-01</date><risdate>1978</risdate><volume>4</volume><issue>3</issue><spage>253</spage><epage>263</epage><pages>253-263</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><abstract>A study was made of a number of factors that might be responsible for the unreliable results obtained in experimentally induced pain in man.
In a randomised, double-blind, cross-over study on 32 healthy, male volunteers, the ischaemic pain test [14] and several psychological tests were performed. The influence of the following factors on the pain test results were examined
1.
(a) ingestion of single, oral doses of 1000 mg aspirin (ASA) and placebo
2.
(b) practice effect
3.
(c) initial pain sensitivity
4.
(d) anxiety, coping behaviour, attitude to the experiment and personality factors.
The analgesic activity of ASA could not be demonstrated. An interaction between primary pain sensitivity and the sequence of drug administration was found. Furthermore, anxiety had a marked influence on the test results. Using experimental pain models reliable results are not to be expected as anxiety fluctuates intra- and interindividually in an unpredictable and uncontrollable manner.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>345198</pmid><doi>10.1016/0304-3959(77)90137-3</doi><tpages>11</tpages></addata></record> |
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| ispartof | Pain (Amsterdam), 1978-01, Vol.4 (3), p.253-263 |
| issn | 0304-3959 1872-6623 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptation, Psychological Adult Anxiety - psychology Aspirin - therapeutic use Attitude Clinical Trials as Topic Double-Blind Method Humans Male Pain - drug therapy Pain - psychology Practice, Psychological Psychological Tests |
| title | The influence of anxiety and pain sensitivity on experimental pain in man |
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