Electroencephalographic study of the short-acting hypnotics etomidate and methohexital in dogs
Beagles, implanted with cortical and subcortical electrodes, were given etomidate i.v. (1 mg/kg) over a period of 10 sec. The effects on the EEG were compared with those obtained with 7 mg/kg of methohexital. Both compounds induced hypnosis for a duration of approximately 8 min. The EEGs showed a re...
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| Veröffentlicht in: | European journal of pharmacology 1978-02, Vol.47 (4), p.367-377 |
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| container_title | European journal of pharmacology |
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| creator | Wauquier, A. Van Den Broeck, W.A.E. Verheyen, J.L. Janssen, P.A.J. |
| description | Beagles, implanted with cortical and subcortical electrodes, were given etomidate i.v. (1 mg/kg) over a period of 10 sec. The effects on the EEG were compared with those obtained with 7 mg/kg of methohexital. Both compounds induced hypnosis for a duration of approximately 8 min. The EEGs showed a remarkable similarity. Visual inspection of the records as well as power spectrum analysis revealed a sustained θ-activity with underlying fast activity. The configuration of the waves was rather sharp. The power obtained after etomidate was, however, 2 to 3 times that obtained after methohexital. When the animals awoke from etomidate-induced hypnosis slow waves appeared and were followed by α-activity, whereas after methohexital-hypnosis β-activity predominated. Etomidate slightly increased heart rate, but respiratory depression was not observed. Methohexital caused pronounced tachycardia and apnoea. In 3 out of 6 dogs methohexital caused myclonus of the hind legs upon awakening from anaesthesia. Etomidate induced myoclonus in one dog during hypnosis. |
| doi_str_mv | 10.1016/0014-2999(78)90117-6 |
| format | Article |
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Etomidate induced myoclonus in one dog during hypnosis.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(78)90117-6</identifier><identifier>PMID: 631187</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Dog ; Dogs ; EEG ; Electrodes, Implanted ; Electroencephalography ; Electromyography ; Electrooculography ; Etomidate ; Etomidate - pharmacology ; Heart Rate - drug effects ; Imidazoles - pharmacology ; Male ; Methohexital ; Methohexital - pharmacology ; Power spectral analysis ; Time Factors</subject><ispartof>European journal of pharmacology, 1978-02, Vol.47 (4), p.367-377</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-9588cb54e4b9fb4ebc11488d4426b545cf469a8e3e7bbf49de627bd9d61750893</citedby><cites>FETCH-LOGICAL-c422t-9588cb54e4b9fb4ebc11488d4426b545cf469a8e3e7bbf49de627bd9d61750893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299978901176$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/631187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wauquier, A.</creatorcontrib><creatorcontrib>Van Den Broeck, W.A.E.</creatorcontrib><creatorcontrib>Verheyen, J.L.</creatorcontrib><creatorcontrib>Janssen, P.A.J.</creatorcontrib><title>Electroencephalographic study of the short-acting hypnotics etomidate and methohexital in dogs</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Beagles, implanted with cortical and subcortical electrodes, were given etomidate i.v. (1 mg/kg) over a period of 10 sec. The effects on the EEG were compared with those obtained with 7 mg/kg of methohexital. Both compounds induced hypnosis for a duration of approximately 8 min. The EEGs showed a remarkable similarity. Visual inspection of the records as well as power spectrum analysis revealed a sustained θ-activity with underlying fast activity. The configuration of the waves was rather sharp. The power obtained after etomidate was, however, 2 to 3 times that obtained after methohexital. When the animals awoke from etomidate-induced hypnosis slow waves appeared and were followed by α-activity, whereas after methohexital-hypnosis β-activity predominated. Etomidate slightly increased heart rate, but respiratory depression was not observed. Methohexital caused pronounced tachycardia and apnoea. In 3 out of 6 dogs methohexital caused myclonus of the hind legs upon awakening from anaesthesia. Etomidate induced myoclonus in one dog during hypnosis.</description><subject>Animals</subject><subject>Dog</subject><subject>Dogs</subject><subject>EEG</subject><subject>Electrodes, Implanted</subject><subject>Electroencephalography</subject><subject>Electromyography</subject><subject>Electrooculography</subject><subject>Etomidate</subject><subject>Etomidate - pharmacology</subject><subject>Heart Rate - drug effects</subject><subject>Imidazoles - pharmacology</subject><subject>Male</subject><subject>Methohexital</subject><subject>Methohexital - pharmacology</subject><subject>Power spectral analysis</subject><subject>Time Factors</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS3EqxT-oAuvECwCduok9gYJVeUhVWIDWyzHnjRGSRxsB9G_J6UVS1YjzZx7pTkIzSi5oYTmt4RQlqRCiKuCXwtCaZHkB2hCeSESUtD0EE3-kFN0FsIHISQTaXaCjvM5HbkJel82oKN30Gnoa9W4tVd9bTUOcTAb7Coca8Chdj4mSkfbrXG96TsXrQ4YomutURGw6gxuIdauhm8bVYNth41bh3N0VKkmwMV-TtHbw_J18ZSsXh6fF_erRLM0jYnIONdlxoCVoioZlJpSxrlhLM3HdaYrlgvFYQ5FWVZMGMjTojTC5LTICBfzKbrc9fbefQ4Qomxt0NA0qgM3BMnnXFAishFkO1B7F4KHSvbetspvJCVya1VulcmtMllw-WtV5mNstu8fyhbMX2incTzf7c4w_vhlwcug7VapsX7UK42z__f_AIsMiCU</recordid><startdate>19780215</startdate><enddate>19780215</enddate><creator>Wauquier, A.</creator><creator>Van Den Broeck, W.A.E.</creator><creator>Verheyen, J.L.</creator><creator>Janssen, P.A.J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780215</creationdate><title>Electroencephalographic study of the short-acting hypnotics etomidate and methohexital in dogs</title><author>Wauquier, A. ; Van Den Broeck, W.A.E. ; Verheyen, J.L. ; Janssen, P.A.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-9588cb54e4b9fb4ebc11488d4426b545cf469a8e3e7bbf49de627bd9d61750893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Dog</topic><topic>Dogs</topic><topic>EEG</topic><topic>Electrodes, Implanted</topic><topic>Electroencephalography</topic><topic>Electromyography</topic><topic>Electrooculography</topic><topic>Etomidate</topic><topic>Etomidate - pharmacology</topic><topic>Heart Rate - drug effects</topic><topic>Imidazoles - pharmacology</topic><topic>Male</topic><topic>Methohexital</topic><topic>Methohexital - pharmacology</topic><topic>Power spectral analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wauquier, A.</creatorcontrib><creatorcontrib>Van Den Broeck, W.A.E.</creatorcontrib><creatorcontrib>Verheyen, J.L.</creatorcontrib><creatorcontrib>Janssen, P.A.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wauquier, A.</au><au>Van Den Broeck, W.A.E.</au><au>Verheyen, J.L.</au><au>Janssen, P.A.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electroencephalographic study of the short-acting hypnotics etomidate and methohexital in dogs</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1978-02-15</date><risdate>1978</risdate><volume>47</volume><issue>4</issue><spage>367</spage><epage>377</epage><pages>367-377</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Beagles, implanted with cortical and subcortical electrodes, were given etomidate i.v. (1 mg/kg) over a period of 10 sec. The effects on the EEG were compared with those obtained with 7 mg/kg of methohexital. Both compounds induced hypnosis for a duration of approximately 8 min. The EEGs showed a remarkable similarity. Visual inspection of the records as well as power spectrum analysis revealed a sustained θ-activity with underlying fast activity. The configuration of the waves was rather sharp. The power obtained after etomidate was, however, 2 to 3 times that obtained after methohexital. When the animals awoke from etomidate-induced hypnosis slow waves appeared and were followed by α-activity, whereas after methohexital-hypnosis β-activity predominated. Etomidate slightly increased heart rate, but respiratory depression was not observed. Methohexital caused pronounced tachycardia and apnoea. In 3 out of 6 dogs methohexital caused myclonus of the hind legs upon awakening from anaesthesia. Etomidate induced myoclonus in one dog during hypnosis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>631187</pmid><doi>10.1016/0014-2999(78)90117-6</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1978-02, Vol.47 (4), p.367-377 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Dog Dogs EEG Electrodes, Implanted Electroencephalography Electromyography Electrooculography Etomidate Etomidate - pharmacology Heart Rate - drug effects Imidazoles - pharmacology Male Methohexital Methohexital - pharmacology Power spectral analysis Time Factors |
| title | Electroencephalographic study of the short-acting hypnotics etomidate and methohexital in dogs |
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