Lymphocyte‐Tumor Cell Interaction in Patients with Head and Neck Cancer
Peripheral lymphocytes from 12 patients with squamous cell carcinoma of the head and neck were incubated with autologous tumor explants. Four of the 12 patients demonstrated lymphocyte induced tumor cytotoxicity. These lymphocytes adhered to the tumor cells and deposited a radioactive label from the...
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| Veröffentlicht in: | The Laryngoscope 1978-04, Vol.88 (4), p.575-581 |
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| container_end_page | 581 |
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| container_issue | 4 |
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| container_title | The Laryngoscope |
| container_volume | 88 |
| creator | Adelstein, Edward H. Davis, William E. Oxenhandler, Ronald W. Templer, Jerry W. Barrett, Barbro A.-L. |
| description | Peripheral lymphocytes from 12 patients with squamous cell carcinoma of the head and neck were incubated with autologous tumor explants. Four of the 12 patients demonstrated lymphocyte induced tumor cytotoxicity. These lymphocytes adhered to the tumor cells and deposited a radioactive label from their surface onto tumor cells. The deposition of this label was associated with tumor death.
Tissue sections from those patients who demonstrated lymphocyte cytotoxicity showed a marked plasmacytic infiltration. This was in contrast to non‐responders where only a desmoplastic tissue response was observed with few inflammatory cells. |
| doi_str_mv | 10.1002/lary.1978.88.4.575 |
| format | Article |
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Tissue sections from those patients who demonstrated lymphocyte cytotoxicity showed a marked plasmacytic infiltration. This was in contrast to non‐responders where only a desmoplastic tissue response was observed with few inflammatory cells.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.1978.88.4.575</identifier><identifier>PMID: 642655</identifier><language>eng</language><publisher>United States</publisher><subject>Autoradiography ; Culture Techniques ; Cytotoxicity, Immunologic ; Head and Neck Neoplasms - immunology ; Head and Neck Neoplasms - pathology ; Humans ; Lymphocytes - immunology ; Neoplasms - pathology</subject><ispartof>The Laryngoscope, 1978-04, Vol.88 (4), p.575-581</ispartof><rights>Copyright © 1978 The Triological Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3525-17f4abe25c9c27757307b03d8238fc68cea9ade0cca84110632e93a40d4a8c8b3</citedby><cites>FETCH-LOGICAL-c3525-17f4abe25c9c27757307b03d8238fc68cea9ade0cca84110632e93a40d4a8c8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/642655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adelstein, Edward H.</creatorcontrib><creatorcontrib>Davis, William E.</creatorcontrib><creatorcontrib>Oxenhandler, Ronald W.</creatorcontrib><creatorcontrib>Templer, Jerry W.</creatorcontrib><creatorcontrib>Barrett, Barbro A.-L.</creatorcontrib><title>Lymphocyte‐Tumor Cell Interaction in Patients with Head and Neck Cancer</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>Peripheral lymphocytes from 12 patients with squamous cell carcinoma of the head and neck were incubated with autologous tumor explants. Four of the 12 patients demonstrated lymphocyte induced tumor cytotoxicity. These lymphocytes adhered to the tumor cells and deposited a radioactive label from their surface onto tumor cells. The deposition of this label was associated with tumor death.
Tissue sections from those patients who demonstrated lymphocyte cytotoxicity showed a marked plasmacytic infiltration. This was in contrast to non‐responders where only a desmoplastic tissue response was observed with few inflammatory cells.</description><subject>Autoradiography</subject><subject>Culture Techniques</subject><subject>Cytotoxicity, Immunologic</subject><subject>Head and Neck Neoplasms - immunology</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Lymphocytes - immunology</subject><subject>Neoplasms - pathology</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlKA0EQhhtxi9EXEA998jZjr9M1F0EGl0BQkQh6ajo9FRydJU5PCLn5CD6jT-LEiGdPRdW_UHyEHHMWc8bEWenaVcxTAzFArGJt9BYZcC15pNJUb5NBb5IRaPG0Tw5CeGWMG6nZHtlNlEi0HpDReFXNXxq_6vDr43OyqJqWZliWdFR32DrfFU1Ni5reu67Augt0WXQv9AZdTl2d01v0bzRztcf2kOzMXBnw6HcOyePV5SS7icZ316PsYhx5qYWOuJkpN0WhfeqFMdpIZqZM5iAkzHwCHl3qcmTeO1Ccs0QKTKVTLFcOPEzlkJxueudt877A0NmqCL5_2dXYLIIFCZAYlfZGsTH6tgmhxZmdt0XVE7Oc2TU-W_4sPT4LYJXt8fWhk9_2xbTC_C-y4dXL5xt5WZS4-kehHV88PK8vAGrd_w0cmH-w</recordid><startdate>197804</startdate><enddate>197804</enddate><creator>Adelstein, Edward H.</creator><creator>Davis, William E.</creator><creator>Oxenhandler, Ronald W.</creator><creator>Templer, Jerry W.</creator><creator>Barrett, Barbro A.-L.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>197804</creationdate><title>Lymphocyte‐Tumor Cell Interaction in Patients with Head and Neck Cancer</title><author>Adelstein, Edward H. ; Davis, William E. ; Oxenhandler, Ronald W. ; Templer, Jerry W. ; Barrett, Barbro A.-L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3525-17f4abe25c9c27757307b03d8238fc68cea9ade0cca84110632e93a40d4a8c8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Autoradiography</topic><topic>Culture Techniques</topic><topic>Cytotoxicity, Immunologic</topic><topic>Head and Neck Neoplasms - immunology</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Lymphocytes - immunology</topic><topic>Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adelstein, Edward H.</creatorcontrib><creatorcontrib>Davis, William E.</creatorcontrib><creatorcontrib>Oxenhandler, Ronald W.</creatorcontrib><creatorcontrib>Templer, Jerry W.</creatorcontrib><creatorcontrib>Barrett, Barbro A.-L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adelstein, Edward H.</au><au>Davis, William E.</au><au>Oxenhandler, Ronald W.</au><au>Templer, Jerry W.</au><au>Barrett, Barbro A.-L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphocyte‐Tumor Cell Interaction in Patients with Head and Neck Cancer</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>1978-04</date><risdate>1978</risdate><volume>88</volume><issue>4</issue><spage>575</spage><epage>581</epage><pages>575-581</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Peripheral lymphocytes from 12 patients with squamous cell carcinoma of the head and neck were incubated with autologous tumor explants. Four of the 12 patients demonstrated lymphocyte induced tumor cytotoxicity. These lymphocytes adhered to the tumor cells and deposited a radioactive label from their surface onto tumor cells. The deposition of this label was associated with tumor death.
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| fulltext | fulltext |
| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 1978-04, Vol.88 (4), p.575-581 |
| issn | 0023-852X 1531-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83886749 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Autoradiography Culture Techniques Cytotoxicity, Immunologic Head and Neck Neoplasms - immunology Head and Neck Neoplasms - pathology Humans Lymphocytes - immunology Neoplasms - pathology |
| title | Lymphocyte‐Tumor Cell Interaction in Patients with Head and Neck Cancer |
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