Neocortical cholinergic neurons in elderly people
Choline acetyltransferase activity (presynaptic cholinergic system) and high affinity binding of cholinergic antagonists (postsynaptic cholinergic system) were measured in brain tissue removed after death from both mentally normal and demented old people. Muscarinic receptor binding sites in frontal...
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| Veröffentlicht in: | The Lancet (British edition) 1977-03, Vol.1 (8013), p.668-671 |
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| container_issue | 8013 |
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| container_title | The Lancet (British edition) |
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| creator | White, P Hiley, C R Goodhardt, M J Carrasco, L H Keet, J P Williams, I E Bowen, D M |
| description | Choline acetyltransferase activity (presynaptic cholinergic system) and high affinity binding of cholinergic antagonists (postsynaptic cholinergic system) were measured in brain tissue removed after death from both mentally normal and demented old people. Muscarinic receptor binding sites in frontal cortex decreased with advancing years only in old people without appreciable morphological evidence of senile degeration. Preliminary data for temporal lobe suggested that also in Pick's disease the density of receptor binding sites is reduced. The markers are not significantly reduced in cases of mixed senile and vascular dementia. However, in non-vascular senile dementia of the Alzheimer type, there were indications that the presynaptic marker is selectively depleted. Therefore, centrally acting anticholinesterases might be beneficial, particularly in the early stages of the disease. |
| doi_str_mv | 10.1016/S0140-6736(77)92113-4 |
| format | Article |
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Muscarinic receptor binding sites in frontal cortex decreased with advancing years only in old people without appreciable morphological evidence of senile degeration. Preliminary data for temporal lobe suggested that also in Pick's disease the density of receptor binding sites is reduced. The markers are not significantly reduced in cases of mixed senile and vascular dementia. However, in non-vascular senile dementia of the Alzheimer type, there were indications that the presynaptic marker is selectively depleted. Therefore, centrally acting anticholinesterases might be beneficial, particularly in the early stages of the disease.</description><identifier>ISSN: 0140-6736</identifier><identifier>DOI: 10.1016/S0140-6736(77)92113-4</identifier><identifier>PMID: 66473</identifier><language>eng</language><publisher>England</publisher><subject>Age Factors ; Aged ; Aging ; Alzheimer Disease - enzymology ; Alzheimer Disease - etiology ; Alzheimer Disease - pathology ; Binding Sites ; Choline O-Acetyltransferase - deficiency ; Cholinergic Fibers - pathology ; Cholinesterase Inhibitors - therapeutic use ; Dementia - drug therapy ; Dementia - enzymology ; Dementia - etiology ; Dementia - pathology ; Frontal Lobe - enzymology ; Frontal Lobe - pathology ; Humans ; Receptors, Cholinergic ; Receptors, Muscarinic</subject><ispartof>The Lancet (British edition), 1977-03, Vol.1 (8013), p.668-671</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/66473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>White, P</creatorcontrib><creatorcontrib>Hiley, C R</creatorcontrib><creatorcontrib>Goodhardt, M J</creatorcontrib><creatorcontrib>Carrasco, L H</creatorcontrib><creatorcontrib>Keet, J P</creatorcontrib><creatorcontrib>Williams, I E</creatorcontrib><creatorcontrib>Bowen, D M</creatorcontrib><title>Neocortical cholinergic neurons in elderly people</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Choline acetyltransferase activity (presynaptic cholinergic system) and high affinity binding of cholinergic antagonists (postsynaptic cholinergic system) were measured in brain tissue removed after death from both mentally normal and demented old people. Muscarinic receptor binding sites in frontal cortex decreased with advancing years only in old people without appreciable morphological evidence of senile degeration. Preliminary data for temporal lobe suggested that also in Pick's disease the density of receptor binding sites is reduced. The markers are not significantly reduced in cases of mixed senile and vascular dementia. However, in non-vascular senile dementia of the Alzheimer type, there were indications that the presynaptic marker is selectively depleted. Therefore, centrally acting anticholinesterases might be beneficial, particularly in the early stages of the disease.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aging</subject><subject>Alzheimer Disease - enzymology</subject><subject>Alzheimer Disease - etiology</subject><subject>Alzheimer Disease - pathology</subject><subject>Binding Sites</subject><subject>Choline O-Acetyltransferase - deficiency</subject><subject>Cholinergic Fibers - pathology</subject><subject>Cholinesterase Inhibitors - therapeutic use</subject><subject>Dementia - drug therapy</subject><subject>Dementia - enzymology</subject><subject>Dementia - etiology</subject><subject>Dementia - pathology</subject><subject>Frontal Lobe - enzymology</subject><subject>Frontal Lobe - pathology</subject><subject>Humans</subject><subject>Receptors, Cholinergic</subject><subject>Receptors, Muscarinic</subject><issn>0140-6736</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j01LxDAURbNw0HH0F4jQleii-l6TJulShvEDBl2o65ImT42kTU2mi_n3Djq4uBy4HC5cxs4RrhFQ3rwACiil4vJSqaumQuSlOGDz__qIHef8BQBCQn3IZlIKxecMnyjamDbemlDYzxj8QOnD22KgKcUhF34oKDhKYVuMFMdAJ2z2bkKm0z0X7O1u9bp8KNfP94_L23U5ViA2ZUM1ua5R4JyyypBQGnfhVDmulTBaopYghes6qi2B1lg3FpBX3KHriC_Yxd_umOL3RHnT9j5bCsEMFKfcaq5rLaTYiWd7cep6cu2YfG_Stv19yH8AI3RQ5A</recordid><startdate>19770326</startdate><enddate>19770326</enddate><creator>White, P</creator><creator>Hiley, C R</creator><creator>Goodhardt, M J</creator><creator>Carrasco, L H</creator><creator>Keet, J P</creator><creator>Williams, I E</creator><creator>Bowen, D M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19770326</creationdate><title>Neocortical cholinergic neurons in elderly people</title><author>White, P ; Hiley, C R ; Goodhardt, M J ; Carrasco, L H ; Keet, J P ; Williams, I E ; Bowen, D M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p204t-9e5edb970dd7c7ae47814783e2d3874a86186064dbbe5ce088159c01323d1dbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aging</topic><topic>Alzheimer Disease - enzymology</topic><topic>Alzheimer Disease - etiology</topic><topic>Alzheimer Disease - pathology</topic><topic>Binding Sites</topic><topic>Choline O-Acetyltransferase - deficiency</topic><topic>Cholinergic Fibers - pathology</topic><topic>Cholinesterase Inhibitors - therapeutic use</topic><topic>Dementia - drug therapy</topic><topic>Dementia - enzymology</topic><topic>Dementia - etiology</topic><topic>Dementia - pathology</topic><topic>Frontal Lobe - enzymology</topic><topic>Frontal Lobe - pathology</topic><topic>Humans</topic><topic>Receptors, Cholinergic</topic><topic>Receptors, Muscarinic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>White, P</creatorcontrib><creatorcontrib>Hiley, C R</creatorcontrib><creatorcontrib>Goodhardt, M J</creatorcontrib><creatorcontrib>Carrasco, L H</creatorcontrib><creatorcontrib>Keet, J P</creatorcontrib><creatorcontrib>Williams, I E</creatorcontrib><creatorcontrib>Bowen, D M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>White, P</au><au>Hiley, C R</au><au>Goodhardt, M J</au><au>Carrasco, L H</au><au>Keet, J P</au><au>Williams, I E</au><au>Bowen, D M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neocortical cholinergic neurons in elderly people</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1977-03-26</date><risdate>1977</risdate><volume>1</volume><issue>8013</issue><spage>668</spage><epage>671</epage><pages>668-671</pages><issn>0140-6736</issn><abstract>Choline acetyltransferase activity (presynaptic cholinergic system) and high affinity binding of cholinergic antagonists (postsynaptic cholinergic system) were measured in brain tissue removed after death from both mentally normal and demented old people. 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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1977-03, Vol.1 (8013), p.668-671 |
| issn | 0140-6736 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age Factors Aged Aging Alzheimer Disease - enzymology Alzheimer Disease - etiology Alzheimer Disease - pathology Binding Sites Choline O-Acetyltransferase - deficiency Cholinergic Fibers - pathology Cholinesterase Inhibitors - therapeutic use Dementia - drug therapy Dementia - enzymology Dementia - etiology Dementia - pathology Frontal Lobe - enzymology Frontal Lobe - pathology Humans Receptors, Cholinergic Receptors, Muscarinic |
| title | Neocortical cholinergic neurons in elderly people |
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