Prostacyclin: A Potentially Valuable Agent for Preserving Myocardial Tissue in Acute Myocardial Ischemia
Prostacyclin, a potent, naturally occurring prostaglandin exerts a variety of cardiovascular and cellular actions of potential value in acute myocardial ischemia. These properties include the reduction of systemic blood pressure without changing heart rate, the lowering of coronary vascular and tota...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1978-04, Vol.200 (4337), p.52-54 |
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| container_end_page | 54 |
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| container_issue | 4337 |
| container_start_page | 52 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 200 |
| creator | Lefer, Allan M. Ogletree, Martin L. Smith, J. Bryan Silver, Melvin J. Nicolaou, Kyriacos C. Barnette, William E. Gasic, Gregory P. |
| description | Prostacyclin, a potent, naturally occurring prostaglandin exerts a variety of cardiovascular and cellular actions of potential value in acute myocardial ischemia. These properties include the reduction of systemic blood pressure without changing heart rate, the lowering of coronary vascular and total peripheral resistance, the inhibition of platelet aggregation and the concomitant formation of thromboxane B$_{2}$, and the reduction of the release of lysosomal enzymes. |
| doi_str_mv | 10.1126/science.345441 |
| format | Article |
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Bryan ; Silver, Melvin J. ; Nicolaou, Kyriacos C. ; Barnette, William E. ; Gasic, Gregory P.</creator><creatorcontrib>Lefer, Allan M. ; Ogletree, Martin L. ; Smith, J. Bryan ; Silver, Melvin J. ; Nicolaou, Kyriacos C. ; Barnette, William E. ; Gasic, Gregory P.</creatorcontrib><description>Prostacyclin, a potent, naturally occurring prostaglandin exerts a variety of cardiovascular and cellular actions of potential value in acute myocardial ischemia. These properties include the reduction of systemic blood pressure without changing heart rate, the lowering of coronary vascular and total peripheral resistance, the inhibition of platelet aggregation and the concomitant formation of thromboxane B$_{2}$, and the reduction of the release of lysosomal enzymes.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.345441</identifier><identifier>PMID: 345441</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Blood pressure ; Blood Pressure - drug effects ; Cats ; Coronary Circulation - drug effects ; Coronary Disease - drug therapy ; Epoprostenol - pharmacology ; Epoprostenol - therapeutic use ; Heart rate ; Heart Rate - drug effects ; Hemodynamics - drug effects ; In Vitro Techniques ; Lysosomes - drug effects ; Lysosomes - enzymology ; Myocardial Contraction - drug effects ; Myocardial ischemia ; Perfusion ; Platelet aggregation ; Platelet Aggregation - drug effects ; Prostaglandins ; Prostaglandins - pharmacology ; Thromboxanes ; Thromboxanes - blood ; Vascular resistance ; Vascular Resistance - drug effects ; Vasodilation ; Vehicles</subject><ispartof>Science (American Association for the Advancement of Science), 1978-04, Vol.200 (4337), p.52-54</ispartof><rights>Copyright 1978 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-90b1774f841552ff566fca8990e1ac4f6314f94f419987df094882920b628a503</citedby><cites>FETCH-LOGICAL-c405t-90b1774f841552ff566fca8990e1ac4f6314f94f419987df094882920b628a503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1745464$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1745464$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/345441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lefer, Allan M.</creatorcontrib><creatorcontrib>Ogletree, Martin L.</creatorcontrib><creatorcontrib>Smith, J. Bryan</creatorcontrib><creatorcontrib>Silver, Melvin J.</creatorcontrib><creatorcontrib>Nicolaou, Kyriacos C.</creatorcontrib><creatorcontrib>Barnette, William E.</creatorcontrib><creatorcontrib>Gasic, Gregory P.</creatorcontrib><title>Prostacyclin: A Potentially Valuable Agent for Preserving Myocardial Tissue in Acute Myocardial Ischemia</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Prostacyclin, a potent, naturally occurring prostaglandin exerts a variety of cardiovascular and cellular actions of potential value in acute myocardial ischemia. These properties include the reduction of systemic blood pressure without changing heart rate, the lowering of coronary vascular and total peripheral resistance, the inhibition of platelet aggregation and the concomitant formation of thromboxane B$_{2}$, and the reduction of the release of lysosomal enzymes.</description><subject>Animals</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Cats</subject><subject>Coronary Circulation - drug effects</subject><subject>Coronary Disease - drug therapy</subject><subject>Epoprostenol - pharmacology</subject><subject>Epoprostenol - therapeutic use</subject><subject>Heart rate</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>In Vitro Techniques</subject><subject>Lysosomes - drug effects</subject><subject>Lysosomes - enzymology</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardial ischemia</subject><subject>Perfusion</subject><subject>Platelet aggregation</subject><subject>Platelet Aggregation - drug effects</subject><subject>Prostaglandins</subject><subject>Prostaglandins - pharmacology</subject><subject>Thromboxanes</subject><subject>Thromboxanes - blood</subject><subject>Vascular resistance</subject><subject>Vascular Resistance - drug effects</subject><subject>Vasodilation</subject><subject>Vehicles</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkDtPwzAURi3EqxRWJgZPbCl2bCc2W1XxkoroUFgjx71uXeVR7AQp_55UqQAxXel-537SPQhdUzKhNE7ugnFQGZgwLjinR2hEiRKRigk7RiNCWBJJkopzdBHClpA-U-wMnQ70CG0Wvg6NNp0pXHWPp3hRN1A1ThdFhz900eq8ADxd9ztsa48XHgL4L1et8WtXG-1XPYqXLoQWsKvw1LQN_I1egtlA6fQlOrG6CHB1mGP0_viwnD1H87enl9l0HhlORBMpktM05VZyKkRsrUgSa7RUigDVhtuEUW4Vt5wqJdOVJYpLGfff5kkstSBsjG6H3p2vP1sITVa6YKAodAV1GzLJpIhjugcnA2h6A8GDzXbeldp3GSXZ3mx2MJsNrvqDm0Nzm5ew-sH_x9vQ1P63LO3jhLNv6cZ-mA</recordid><startdate>19780407</startdate><enddate>19780407</enddate><creator>Lefer, Allan M.</creator><creator>Ogletree, Martin L.</creator><creator>Smith, J. Bryan</creator><creator>Silver, Melvin J.</creator><creator>Nicolaou, Kyriacos C.</creator><creator>Barnette, William E.</creator><creator>Gasic, Gregory P.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780407</creationdate><title>Prostacyclin: A Potentially Valuable Agent for Preserving Myocardial Tissue in Acute Myocardial Ischemia</title><author>Lefer, Allan M. ; Ogletree, Martin L. ; Smith, J. Bryan ; Silver, Melvin J. ; Nicolaou, Kyriacos C. ; Barnette, William E. ; Gasic, Gregory P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-90b1774f841552ff566fca8990e1ac4f6314f94f419987df094882920b628a503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Cats</topic><topic>Coronary Circulation - drug effects</topic><topic>Coronary Disease - drug therapy</topic><topic>Epoprostenol - pharmacology</topic><topic>Epoprostenol - therapeutic use</topic><topic>Heart rate</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>In Vitro Techniques</topic><topic>Lysosomes - drug effects</topic><topic>Lysosomes - enzymology</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardial ischemia</topic><topic>Perfusion</topic><topic>Platelet aggregation</topic><topic>Platelet Aggregation - drug effects</topic><topic>Prostaglandins</topic><topic>Prostaglandins - pharmacology</topic><topic>Thromboxanes</topic><topic>Thromboxanes - blood</topic><topic>Vascular resistance</topic><topic>Vascular Resistance - drug effects</topic><topic>Vasodilation</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lefer, Allan M.</creatorcontrib><creatorcontrib>Ogletree, Martin L.</creatorcontrib><creatorcontrib>Smith, J. 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Bryan</au><au>Silver, Melvin J.</au><au>Nicolaou, Kyriacos C.</au><au>Barnette, William E.</au><au>Gasic, Gregory P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostacyclin: A Potentially Valuable Agent for Preserving Myocardial Tissue in Acute Myocardial Ischemia</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1978-04-07</date><risdate>1978</risdate><volume>200</volume><issue>4337</issue><spage>52</spage><epage>54</epage><pages>52-54</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Prostacyclin, a potent, naturally occurring prostaglandin exerts a variety of cardiovascular and cellular actions of potential value in acute myocardial ischemia. These properties include the reduction of systemic blood pressure without changing heart rate, the lowering of coronary vascular and total peripheral resistance, the inhibition of platelet aggregation and the concomitant formation of thromboxane B$_{2}$, and the reduction of the release of lysosomal enzymes.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>345441</pmid><doi>10.1126/science.345441</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1978-04, Vol.200 (4337), p.52-54 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83852210 |
| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Animals Blood pressure Blood Pressure - drug effects Cats Coronary Circulation - drug effects Coronary Disease - drug therapy Epoprostenol - pharmacology Epoprostenol - therapeutic use Heart rate Heart Rate - drug effects Hemodynamics - drug effects In Vitro Techniques Lysosomes - drug effects Lysosomes - enzymology Myocardial Contraction - drug effects Myocardial ischemia Perfusion Platelet aggregation Platelet Aggregation - drug effects Prostaglandins Prostaglandins - pharmacology Thromboxanes Thromboxanes - blood Vascular resistance Vascular Resistance - drug effects Vasodilation Vehicles |
| title | Prostacyclin: A Potentially Valuable Agent for Preserving Myocardial Tissue in Acute Myocardial Ischemia |
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