Site and Extent of Thiamin Absorption in the Rat
The site and extent of absorption of thiamin hydrochloride was determined in rats using 51Cr-EDTA as a non-absorbed reference substance. The main site of absorption of thiamin was found to be the proximal 22 cm of the small intestine with relatively little absorption occurring distally, particularly...
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| Veröffentlicht in: | The Journal of nutrition 1977-03, Vol.107 (3), p.353-356 |
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| container_end_page | 356 |
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| container_issue | 3 |
| container_start_page | 353 |
| container_title | The Journal of nutrition |
| container_volume | 107 |
| creator | Sklan, D. Trostler, Naomi |
| description | The site and extent of absorption of thiamin hydrochloride was determined in rats using 51Cr-EDTA as a non-absorbed reference substance. The main site of absorption of thiamin was found to be the proximal 22 cm of the small intestine with relatively little absorption occurring distally, particularly at low dietary thiamin levels. Concentration of thiamin in the intestinal contents increased along the intestine reaching maximum levels in the distal small intestine. The results are compatible with two concurrent mechanisms of thiamin absorption with the active absorptive process being saturated at 0.5 to 1.0 µM. |
| doi_str_mv | 10.1093/jn/107.3.353 |
| format | Article |
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The results are compatible with two concurrent mechanisms of thiamin absorption with the active absorptive process being saturated at 0.5 to 1.0 µM.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/107.3.353</identifier><identifier>PMID: 403258</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>51Cr ; absorption ; Animals ; Chromium Radioisotopes ; Diet ; Edetic Acid ; Female ; Intestinal Absorption ; Rats ; thiamin ; Thiamine - administration & dosage ; Thiamine - metabolism</subject><ispartof>The Journal of nutrition, 1977-03, Vol.107 (3), p.353-356</ispartof><rights>1977 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-d275a4f0a9ad52ec5d178006752f5b84df78e678ea33c684bea7f99558167be73</citedby><cites>FETCH-LOGICAL-c393t-d275a4f0a9ad52ec5d178006752f5b84df78e678ea33c684bea7f99558167be73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/403258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sklan, D.</creatorcontrib><creatorcontrib>Trostler, Naomi</creatorcontrib><creatorcontrib>Landbouwhogeschool Wageningen (Netherlands). Vakgroep Humane Voeding</creatorcontrib><title>Site and Extent of Thiamin Absorption in the Rat</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The site and extent of absorption of thiamin hydrochloride was determined in rats using 51Cr-EDTA as a non-absorbed reference substance. The main site of absorption of thiamin was found to be the proximal 22 cm of the small intestine with relatively little absorption occurring distally, particularly at low dietary thiamin levels. Concentration of thiamin in the intestinal contents increased along the intestine reaching maximum levels in the distal small intestine. The results are compatible with two concurrent mechanisms of thiamin absorption with the active absorptive process being saturated at 0.5 to 1.0 µM.</description><subject>51Cr</subject><subject>absorption</subject><subject>Animals</subject><subject>Chromium Radioisotopes</subject><subject>Diet</subject><subject>Edetic Acid</subject><subject>Female</subject><subject>Intestinal Absorption</subject><subject>Rats</subject><subject>thiamin</subject><subject>Thiamine - administration & dosage</subject><subject>Thiamine - metabolism</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1LAzEQxYP4Vas3jyJ78uS2k02yyR5LqR9QEGx7DtndWZvS7tYkFf3vjax48jA8hvfjDfMIuaYwolCw8aYdU5AjNmKCHZEBFZymOQU4JgOALEsZzfNzcuH9BgAoL9QZOeXAMqEGBBY2YGLaOpl9BmxD0jXJcm3NzrbJpPSd2wfbtUncwhqTVxMuyUljth6vfnVIVg-z5fQpnb88Pk8n87RiBQtpnUlheAOmMLXIsBI1lQoglyJrRKl43UiFeRzDWJUrXqKRTVEIoWguS5RsSO763L3r3g_og95ZX-F2a1rsDl4rpjiP30Twvgcr13nvsNF7Z3fGfWkK-qcfvWmjSs107CfiN7-5h3KH9R_cFxLt295uTKfNm7Nerxa0kBKo4jKjEch7AOPzHxad9pXFtsLaOqyCrjv7_-Fvlt55lg</recordid><startdate>197703</startdate><enddate>197703</enddate><creator>Sklan, D.</creator><creator>Trostler, Naomi</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197703</creationdate><title>Site and Extent of Thiamin Absorption in the Rat</title><author>Sklan, D. ; Trostler, Naomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-d275a4f0a9ad52ec5d178006752f5b84df78e678ea33c684bea7f99558167be73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>51Cr</topic><topic>absorption</topic><topic>Animals</topic><topic>Chromium Radioisotopes</topic><topic>Diet</topic><topic>Edetic Acid</topic><topic>Female</topic><topic>Intestinal Absorption</topic><topic>Rats</topic><topic>thiamin</topic><topic>Thiamine - administration & dosage</topic><topic>Thiamine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sklan, D.</creatorcontrib><creatorcontrib>Trostler, Naomi</creatorcontrib><creatorcontrib>Landbouwhogeschool Wageningen (Netherlands). 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The results are compatible with two concurrent mechanisms of thiamin absorption with the active absorptive process being saturated at 0.5 to 1.0 µM.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>403258</pmid><doi>10.1093/jn/107.3.353</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 1977-03, Vol.107 (3), p.353-356 |
| issn | 0022-3166 1541-6100 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83844014 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 51Cr absorption Animals Chromium Radioisotopes Diet Edetic Acid Female Intestinal Absorption Rats thiamin Thiamine - administration & dosage Thiamine - metabolism |
| title | Site and Extent of Thiamin Absorption in the Rat |
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