Urinary citrate excretion in the diagnosis of distal renal tubular acidosis
Since hypocitraturia occurs in distal renal tubular acidosis, we screened the asymptomatic children in three families with familial dRTA, by comparing their 24-hour urine citrate excretion to values obtained in 45 normal children. Subsequent acid loading uncovered four new cases of dRTA suspected be...
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| Veröffentlicht in: | The Journal of pediatrics 1978-03, Vol.92 (3), p.394-400 |
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| container_title | The Journal of pediatrics |
| container_volume | 92 |
| creator | Norman, Michael E. Feldman, Nathan I. Cohn, Robert M. Roth, Karl S. McCurdy, Donna K. |
| description | Since hypocitraturia occurs in distal renal tubular acidosis, we screened the asymptomatic children in three families with familial dRTA, by comparing their 24-hour urine citrate excretion to values obtained in 45 normal children. Subsequent acid loading uncovered four new cases of dRTA suspected because of the finding of hypocitraturia. Because hypocitraturia probably contributes to nephrolithiasis/nephrocalcinosis and subsequent renal damage in dRTA, affected family members were treated with alkali (4 mEq/kg/day), which normalized urine citrate in three children; in a fourth child citrate excretion rose but was not normal. Measurement of urine citrate excretion was superior to other currently proposed screening tests for dRTA (first morning urine pH and sediment, urine concentration). |
| doi_str_mv | 10.1016/S0022-3476(78)80426-0 |
| format | Article |
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Subsequent acid loading uncovered four new cases of dRTA suspected because of the finding of hypocitraturia. Because hypocitraturia probably contributes to nephrolithiasis/nephrocalcinosis and subsequent renal damage in dRTA, affected family members were treated with alkali (4 mEq/kg/day), which normalized urine citrate in three children; in a fourth child citrate excretion rose but was not normal. Measurement of urine citrate excretion was superior to other currently proposed screening tests for dRTA (first morning urine pH and sediment, urine concentration).</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(78)80426-0</identifier><identifier>PMID: 632978</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Acidosis, Renal Tubular - diagnosis ; Acidosis, Renal Tubular - genetics ; Acidosis, Renal Tubular - urine ; Adult ; Child ; Citrates - urine ; Female ; Humans ; Kidney Tubules, Distal ; Male</subject><ispartof>The Journal of pediatrics, 1978-03, Vol.92 (3), p.394-400</ispartof><rights>1978 The C. V. 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Subsequent acid loading uncovered four new cases of dRTA suspected because of the finding of hypocitraturia. Because hypocitraturia probably contributes to nephrolithiasis/nephrocalcinosis and subsequent renal damage in dRTA, affected family members were treated with alkali (4 mEq/kg/day), which normalized urine citrate in three children; in a fourth child citrate excretion rose but was not normal. Measurement of urine citrate excretion was superior to other currently proposed screening tests for dRTA (first morning urine pH and sediment, urine concentration).</description><subject>Acidosis, Renal Tubular - diagnosis</subject><subject>Acidosis, Renal Tubular - genetics</subject><subject>Acidosis, Renal Tubular - urine</subject><subject>Adult</subject><subject>Child</subject><subject>Citrates - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Tubules, Distal</subject><subject>Male</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS3EqxT-AKSsECwC49i1nRVCFS9RiQV0bbn2BIzSpNgOgr8nfahbNjMazb1zNYeQMwpXFKi4fgUoipxxKS6kulTAC5HDDhlQKGUuFGO7ZLCVHJKjGD8BoOQAB2RfsKKUakCep8E3Jvxm1qdgEmb4YwMm3zaZb7L0gZnz5r1po49ZW_VDTKbOAjZ9Td2sq03IjPVuKTgme5WpI55s-pBM7-_exo_55OXhaXw7yS0vRik3IJR1XFKuaFkKLrkrCkspozM7QgtYOcEkV2AZVGhsWTGr2GjGpRJUVo4Nyfn67iK0Xx3GpOc-Wqxr02DbRa2Y4sAK3gtHa6ENbYwBK70Ift5_qynoJUO9YqiXgLRUesVQQ-873QR0szm6rWsNrV_frNfYP_ntMehoPTYWnQ9ok3at_yfgD-6AgLM</recordid><startdate>197803</startdate><enddate>197803</enddate><creator>Norman, Michael E.</creator><creator>Feldman, Nathan I.</creator><creator>Cohn, Robert M.</creator><creator>Roth, Karl S.</creator><creator>McCurdy, Donna K.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197803</creationdate><title>Urinary citrate excretion in the diagnosis of distal renal tubular acidosis</title><author>Norman, Michael E. ; Feldman, Nathan I. ; Cohn, Robert M. ; Roth, Karl S. ; McCurdy, Donna K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-a068cd471481996474d22c1131bc5ec0efd637480c30feac9f3c835b478617fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Acidosis, Renal Tubular - diagnosis</topic><topic>Acidosis, Renal Tubular - genetics</topic><topic>Acidosis, Renal Tubular - urine</topic><topic>Adult</topic><topic>Child</topic><topic>Citrates - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Tubules, Distal</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norman, Michael E.</creatorcontrib><creatorcontrib>Feldman, Nathan I.</creatorcontrib><creatorcontrib>Cohn, Robert M.</creatorcontrib><creatorcontrib>Roth, Karl S.</creatorcontrib><creatorcontrib>McCurdy, Donna K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norman, Michael E.</au><au>Feldman, Nathan I.</au><au>Cohn, Robert M.</au><au>Roth, Karl S.</au><au>McCurdy, Donna K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary citrate excretion in the diagnosis of distal renal tubular acidosis</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1978-03</date><risdate>1978</risdate><volume>92</volume><issue>3</issue><spage>394</spage><epage>400</epage><pages>394-400</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Since hypocitraturia occurs in distal renal tubular acidosis, we screened the asymptomatic children in three families with familial dRTA, by comparing their 24-hour urine citrate excretion to values obtained in 45 normal children. Subsequent acid loading uncovered four new cases of dRTA suspected because of the finding of hypocitraturia. Because hypocitraturia probably contributes to nephrolithiasis/nephrocalcinosis and subsequent renal damage in dRTA, affected family members were treated with alkali (4 mEq/kg/day), which normalized urine citrate in three children; in a fourth child citrate excretion rose but was not normal. Measurement of urine citrate excretion was superior to other currently proposed screening tests for dRTA (first morning urine pH and sediment, urine concentration).</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>632978</pmid><doi>10.1016/S0022-3476(78)80426-0</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 1978-03, Vol.92 (3), p.394-400 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acidosis, Renal Tubular - diagnosis Acidosis, Renal Tubular - genetics Acidosis, Renal Tubular - urine Adult Child Citrates - urine Female Humans Kidney Tubules, Distal Male |
| title | Urinary citrate excretion in the diagnosis of distal renal tubular acidosis |
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