Stochastic Theory of Ligand Migration in Biomolecules
When ligand binding to proteins involves the presence of more than one ligand inside a given biomolecule, linear deterministic rate equations become useless. A stochastic approach, however, permits a treatment of the migration and binding of small molecules to proteins even at high ligand concentrat...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1978-01, Vol.75 (1), p.26-29 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 29 |
|---|---|
| container_issue | 1 |
| container_start_page | 26 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 75 |
| creator | Alberding, N. Frauenfelder, H. Hanggi, P. |
| description | When ligand binding to proteins involves the presence of more than one ligand inside a given biomolecule, linear deterministic rate equations become useless. A stochastic approach, however, permits a treatment of the migration and binding of small molecules to proteins even at high ligand concentrations. An appropriate linear master equation and its analytic solution are given. As an example, the binding of carbon monoxide to myoglobin at partial pressures from 1 to 103bars (0.1 to 100 MPa) is treated. |
| doi_str_mv | 10.1073/pnas.75.1.26 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_83839235</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>67567</jstor_id><sourcerecordid>67567</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-ed8aa4f0f6f12ebe80b1eea174c16d519c6387b2e7595fd26232c297db963b2e3</originalsourceid><addsrcrecordid>eNp1kDtv2zAURomiaeOk2TolGTQEmSKXb0pDh8TIo4CLDk1ngqKubBqy6JBUEf_7yrDjJEMnAvec7_LiQ-grwWOCFfu26kwcKzEmYyo_oBHBJcklL_FHNMKYqrzglB-ioxgXGONSFPgz-kQVlZyMkPidvJ2bmJzNHufgwzrzTTZ1M9PV2U83CyY532Wuy26cX_oWbN9C_IIOGtNGONm9x-jP3e3j5CGf_rr_Mbme5pZzkXKoC2N4gxvZEAoVFLgiAIYobomsBSmtZIWqKChRiqamkjJqaanqqpRsGLNj9H27d9VXS6gtdCmYVq-CW5qw1t44_Z50bq5n_q_mhBAlhvzlLh_8Uw8x6aWLFtrWdOD7qAtWsJKyjXi1FW3wMQZo9n8QrDcl603JWglNNJWDfv72rr28bXXAZzu8Cb3A1_DF_6lu-rZN8JwG7XSrLWLyYe9JJaRi_wD37Jib</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83839235</pqid></control><display><type>article</type><title>Stochastic Theory of Ligand Migration in Biomolecules</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Alberding, N. ; Frauenfelder, H. ; Hanggi, P.</creator><creatorcontrib>Alberding, N. ; Frauenfelder, H. ; Hanggi, P.</creatorcontrib><description>When ligand binding to proteins involves the presence of more than one ligand inside a given biomolecule, linear deterministic rate equations become useless. A stochastic approach, however, permits a treatment of the migration and binding of small molecules to proteins even at high ligand concentrations. An appropriate linear master equation and its analytic solution are given. As an example, the binding of carbon monoxide to myoglobin at partial pressures from 1 to 103bars (0.1 to 100 MPa) is treated.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.75.1.26</identifier><identifier>PMID: 272641</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Binding Sites ; Biomolecules ; Carbon Monoxide ; Determinism ; Hemeproteins ; Ligands ; Logical givens ; Models, Chemical ; Molecules ; Myoglobin ; Photolysis ; Protein Binding ; Proteins ; Solvents ; Visible spectrum</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1978-01, Vol.75 (1), p.26-29</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-ed8aa4f0f6f12ebe80b1eea174c16d519c6387b2e7595fd26232c297db963b2e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/75/1.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/67567$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/67567$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27923,27924,53790,53792,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/272641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alberding, N.</creatorcontrib><creatorcontrib>Frauenfelder, H.</creatorcontrib><creatorcontrib>Hanggi, P.</creatorcontrib><title>Stochastic Theory of Ligand Migration in Biomolecules</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>When ligand binding to proteins involves the presence of more than one ligand inside a given biomolecule, linear deterministic rate equations become useless. A stochastic approach, however, permits a treatment of the migration and binding of small molecules to proteins even at high ligand concentrations. An appropriate linear master equation and its analytic solution are given. As an example, the binding of carbon monoxide to myoglobin at partial pressures from 1 to 103bars (0.1 to 100 MPa) is treated.</description><subject>Binding Sites</subject><subject>Biomolecules</subject><subject>Carbon Monoxide</subject><subject>Determinism</subject><subject>Hemeproteins</subject><subject>Ligands</subject><subject>Logical givens</subject><subject>Models, Chemical</subject><subject>Molecules</subject><subject>Myoglobin</subject><subject>Photolysis</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Solvents</subject><subject>Visible spectrum</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtv2zAURomiaeOk2TolGTQEmSKXb0pDh8TIo4CLDk1ngqKubBqy6JBUEf_7yrDjJEMnAvec7_LiQ-grwWOCFfu26kwcKzEmYyo_oBHBJcklL_FHNMKYqrzglB-ioxgXGONSFPgz-kQVlZyMkPidvJ2bmJzNHufgwzrzTTZ1M9PV2U83CyY532Wuy26cX_oWbN9C_IIOGtNGONm9x-jP3e3j5CGf_rr_Mbme5pZzkXKoC2N4gxvZEAoVFLgiAIYobomsBSmtZIWqKChRiqamkjJqaanqqpRsGLNj9H27d9VXS6gtdCmYVq-CW5qw1t44_Z50bq5n_q_mhBAlhvzlLh_8Uw8x6aWLFtrWdOD7qAtWsJKyjXi1FW3wMQZo9n8QrDcl603JWglNNJWDfv72rr28bXXAZzu8Cb3A1_DF_6lu-rZN8JwG7XSrLWLyYe9JJaRi_wD37Jib</recordid><startdate>19780101</startdate><enddate>19780101</enddate><creator>Alberding, N.</creator><creator>Frauenfelder, H.</creator><creator>Hanggi, P.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19780101</creationdate><title>Stochastic Theory of Ligand Migration in Biomolecules</title><author>Alberding, N. ; Frauenfelder, H. ; Hanggi, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-ed8aa4f0f6f12ebe80b1eea174c16d519c6387b2e7595fd26232c297db963b2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Binding Sites</topic><topic>Biomolecules</topic><topic>Carbon Monoxide</topic><topic>Determinism</topic><topic>Hemeproteins</topic><topic>Ligands</topic><topic>Logical givens</topic><topic>Models, Chemical</topic><topic>Molecules</topic><topic>Myoglobin</topic><topic>Photolysis</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>Solvents</topic><topic>Visible spectrum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alberding, N.</creatorcontrib><creatorcontrib>Frauenfelder, H.</creatorcontrib><creatorcontrib>Hanggi, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alberding, N.</au><au>Frauenfelder, H.</au><au>Hanggi, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stochastic Theory of Ligand Migration in Biomolecules</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1978-01-01</date><risdate>1978</risdate><volume>75</volume><issue>1</issue><spage>26</spage><epage>29</epage><pages>26-29</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>When ligand binding to proteins involves the presence of more than one ligand inside a given biomolecule, linear deterministic rate equations become useless. A stochastic approach, however, permits a treatment of the migration and binding of small molecules to proteins even at high ligand concentrations. An appropriate linear master equation and its analytic solution are given. As an example, the binding of carbon monoxide to myoglobin at partial pressures from 1 to 103bars (0.1 to 100 MPa) is treated.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>272641</pmid><doi>10.1073/pnas.75.1.26</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1978-01, Vol.75 (1), p.26-29 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83839235 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Binding Sites Biomolecules Carbon Monoxide Determinism Hemeproteins Ligands Logical givens Models, Chemical Molecules Myoglobin Photolysis Protein Binding Proteins Solvents Visible spectrum |
| title | Stochastic Theory of Ligand Migration in Biomolecules |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T10%3A11%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stochastic%20Theory%20of%20Ligand%20Migration%20in%20Biomolecules&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Alberding,%20N.&rft.date=1978-01-01&rft.volume=75&rft.issue=1&rft.spage=26&rft.epage=29&rft.pages=26-29&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.75.1.26&rft_dat=%3Cjstor_proqu%3E67567%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83839235&rft_id=info:pmid/272641&rft_jstor_id=67567&rfr_iscdi=true |