Synthesis of Methotrexate Polyglutamates in Cultured Human Cells

We describe the biosynthesis of po1y-γ-glutamyl metabolites of methotrexate in cultured human fibroblasts. The accumulation of polyglutamates by these cells is dependent on the concentration of methotrexate in the culture medium, duration of incubation, and stage of the culture cycle. When [ 3 H]me...

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Veröffentlicht in:	Molecular pharmacology 1978-01, Vol.14 (1), p.210-214
Hauptverfasser:	Rosenblatt, D S, Whitehead, V M, Dupont, M M, Vuchich, M J, Vera, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Fibroblasts - metabolism Glutamates - metabolism Humans Kinetics Methotrexate - metabolism Time Factors
Online-Zugang:	Volltext
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