On the inhibitory potency of imidazole and its derivatives on thromboxane synthetase

The relative inhibitory potency of imidazole and derivatives on thromboxane synthetase from human platelets was found to be increased by substitution of the 1-position and abolished in other positions. The potency of 1-substituted imidazoles was increased as the side chain became more hydrophobic. A...

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Veröffentlicht in:	Biochemical and biophysical research communications 1978-01, Vol.80 (1), p.236-242
Hauptverfasser:	Tai, Hsin-Hsiung, Yuan, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - enzymology Imidazoles - pharmacology Kinetics Lung - enzymology Microsomes - enzymology Oxidoreductases - antagonists & inhibitors Prostaglandins - biosynthesis Radioimmunoassay Sheep Structure-Activity Relationship Thromboxane-A Synthase - antagonists & inhibitors
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