An improved method for O-demethylation of codeine

The O-demethylation of codeine was effected by sodium propylmercaptide in dimethylformamide at 125 degrees C to afford morphine in 80% yield. Similar treatment of thebaine was unrewarding.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1977-01, Vol.20 (1), p.165-166
Hauptverfasser:	Lawson, J. A, DeGraw, J. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Codeine Methylation Morphine - chemical synthesis Sulfhydryl Compounds Temperature Thebaine
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The O-demethylation of codeine was effected by sodium propylmercaptide in dimethylformamide at 125 degrees C to afford morphine in 80% yield. Similar treatment of thebaine was unrewarding.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00211a037