Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: A complex GABA-dopamine interaction
Muscimol is the most potent and specific GABA agonist presently available. The influence of muscimol on two behavioral parameters, dependent on dopamine was studied: locomotor activity and stereotyped gnawing induced by apomorphine, cocaine or methylphenidate. In mice pretreated with a non-sedative...
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| Veröffentlicht in: | Life sciences (1973) 1978, Vol.22 (1), p.75-84 |
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| container_end_page | 84 |
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| container_title | Life sciences (1973) |
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| creator | Scheel-Krüger, J. Christensen, A.V. Arnt, J. |
| description | Muscimol is the most potent and specific GABA agonist presently available. The influence of muscimol on two behavioral parameters, dependent on dopamine was studied: locomotor activity and stereotyped gnawing induced by apomorphine, cocaine or methylphenidate. In mice pretreated with a non-sedative subcutaneous dose of muscimol, a sedative effect was seen a few minutes after the injection of a stimulant dose of the dopaminergic drugs; the combination muscimol - apomorphine being most sedative. Contrastingly, muscimol strongly facilitates the development of stereotyped gnawing induced by higher doses of cocaine, methylphenidate or apomorphine. Pretreatment with α-methyltyrosine, an inhibitor of the catecholamine synthesis given before muscimol, did not antagonize the stereotyped gnawing after cocaine or methylphenidate. This finding suggests that the muscimol effect primarily depends on a direct GABA-ergic mechanism facilitating stereotyped gnawing. |
| doi_str_mv | 10.1016/0024-3205(78)90414-9 |
| format | Article |
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This finding suggests that the muscimol effect primarily depends on a direct GABA-ergic mechanism facilitating stereotyped gnawing.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(78)90414-9</identifier><identifier>PMID: 564437</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Apomorphine - pharmacology ; Basidiomycota ; Behavior - drug effects ; Cocaine - pharmacology ; Dopamine - metabolism ; Dose-Response Relationship, Drug ; gamma-Aminobutyric Acid - metabolism ; Humans ; Isoxazoles - pharmacology ; Male ; Methylphenidate - pharmacology ; Methyltyrosines - pharmacology ; Mice ; Motor Activity - drug effects ; Oxazoles - pharmacology ; Stereotyped Behavior - drug effects</subject><ispartof>Life sciences (1973), 1978, Vol.22 (1), p.75-84</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-556826b17b2a60173b532d515f141a71ceca6b8c49d5746384f565fd84e3d28c3</citedby><cites>FETCH-LOGICAL-c356t-556826b17b2a60173b532d515f141a71ceca6b8c49d5746384f565fd84e3d28c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(78)90414-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,4014,27914,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/564437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scheel-Krüger, J.</creatorcontrib><creatorcontrib>Christensen, A.V.</creatorcontrib><creatorcontrib>Arnt, J.</creatorcontrib><title>Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: A complex GABA-dopamine interaction</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Muscimol is the most potent and specific GABA agonist presently available. The influence of muscimol on two behavioral parameters, dependent on dopamine was studied: locomotor activity and stereotyped gnawing induced by apomorphine, cocaine or methylphenidate. In mice pretreated with a non-sedative subcutaneous dose of muscimol, a sedative effect was seen a few minutes after the injection of a stimulant dose of the dopaminergic drugs; the combination muscimol - apomorphine being most sedative. Contrastingly, muscimol strongly facilitates the development of stereotyped gnawing induced by higher doses of cocaine, methylphenidate or apomorphine. Pretreatment with α-methyltyrosine, an inhibitor of the catecholamine synthesis given before muscimol, did not antagonize the stereotyped gnawing after cocaine or methylphenidate. This finding suggests that the muscimol effect primarily depends on a direct GABA-ergic mechanism facilitating stereotyped gnawing.</description><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Basidiomycota</subject><subject>Behavior - drug effects</subject><subject>Cocaine - pharmacology</subject><subject>Dopamine - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Humans</subject><subject>Isoxazoles - pharmacology</subject><subject>Male</subject><subject>Methylphenidate - pharmacology</subject><subject>Methyltyrosines - pharmacology</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Oxazoles - pharmacology</subject><subject>Stereotyped Behavior - drug effects</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAUhC3E36XwBl14hegiYMe_YVHpUkFBKmIDa8uxT66MkjjYDiI8Ak9dX27pktVZzDcjnRmEzil5TQmVbwhpecNaIl4pfdERTnnTPUA7qlXXEMnoQ7S7R56iZzl_J4QIodgT9FhIzpnaoT-f1-zCFEfswzBAgrkEO44bHqwLYyi2QMa5VCGWbdlwvxZs52IPcQ6_qzTFcsQ2HGa_OvC437CPi53CDOkQHPZpPeS3eI9dnJYRfuHr_bt98w-ptpptXQlxfo4eDXbM8OLunqFvH95_vfrY3Hy5_nS1v2kcE7I0Qkjdyp6qvrWSUMV6wVovqBgop1ZRB87KXjveeaG4ZJoPQorBaw7Mt9qxM_TylLuk-GOFXMwUsoNxtDPENRvNNCNathXkJ9ClmHOCwSwpTDZthhJzXMAc6zXHeo3S5u8Cpqu287v8tZ_A35tOlVf58iRD_fFngGTqADDX7kICV4yP4f_5t-m2l7E</recordid><startdate>1978</startdate><enddate>1978</enddate><creator>Scheel-Krüger, J.</creator><creator>Christensen, A.V.</creator><creator>Arnt, J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1978</creationdate><title>Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: A complex GABA-dopamine interaction</title><author>Scheel-Krüger, J. ; Christensen, A.V. ; Arnt, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-556826b17b2a60173b532d515f141a71ceca6b8c49d5746384f565fd84e3d28c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Apomorphine - pharmacology</topic><topic>Basidiomycota</topic><topic>Behavior - drug effects</topic><topic>Cocaine - pharmacology</topic><topic>Dopamine - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Humans</topic><topic>Isoxazoles - pharmacology</topic><topic>Male</topic><topic>Methylphenidate - pharmacology</topic><topic>Methyltyrosines - pharmacology</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Oxazoles - pharmacology</topic><topic>Stereotyped Behavior - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scheel-Krüger, J.</creatorcontrib><creatorcontrib>Christensen, A.V.</creatorcontrib><creatorcontrib>Arnt, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scheel-Krüger, J.</au><au>Christensen, A.V.</au><au>Arnt, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: A complex GABA-dopamine interaction</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1978</date><risdate>1978</risdate><volume>22</volume><issue>1</issue><spage>75</spage><epage>84</epage><pages>75-84</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Muscimol is the most potent and specific GABA agonist presently available. The influence of muscimol on two behavioral parameters, dependent on dopamine was studied: locomotor activity and stereotyped gnawing induced by apomorphine, cocaine or methylphenidate. In mice pretreated with a non-sedative subcutaneous dose of muscimol, a sedative effect was seen a few minutes after the injection of a stimulant dose of the dopaminergic drugs; the combination muscimol - apomorphine being most sedative. Contrastingly, muscimol strongly facilitates the development of stereotyped gnawing induced by higher doses of cocaine, methylphenidate or apomorphine. Pretreatment with α-methyltyrosine, an inhibitor of the catecholamine synthesis given before muscimol, did not antagonize the stereotyped gnawing after cocaine or methylphenidate. 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| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1978, Vol.22 (1), p.75-84 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Apomorphine - pharmacology Basidiomycota Behavior - drug effects Cocaine - pharmacology Dopamine - metabolism Dose-Response Relationship, Drug gamma-Aminobutyric Acid - metabolism Humans Isoxazoles - pharmacology Male Methylphenidate - pharmacology Methyltyrosines - pharmacology Mice Motor Activity - drug effects Oxazoles - pharmacology Stereotyped Behavior - drug effects |
| title | Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: A complex GABA-dopamine interaction |
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