Effect of Isonicotinic Acid Hydrazide on the Intratumor Injection of BCG
Rats with established subcutaneous tumors were treated by repeated intratumor injections of BCG over a 5-week period. Isonicotinic acid hydrazide (INH) was given to some rats to determine if this drug decreased the effect of BCG on local tumor growth. INH alone had no effect on either survival or tu...
Gespeichert in:
| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1977-02, Vol.58 (2), p.367-368 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 368 |
|---|---|
| container_issue | 2 |
| container_start_page | 367 |
| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 58 |
| creator | Sparks, Frank C. Albert, N. Erick Breeding, James H. |
| description | Rats with established subcutaneous tumors were treated by repeated intratumor injections of BCG over a 5-week period. Isonicotinic acid hydrazide (INH) was given to some rats to determine if this drug decreased the effect of BCG on local tumor growth. INH alone had no effect on either survival or tumor volume. Rats treated with either BCG or BCG and INH had prolonged survivals and smaller tumor volumes than did control rats. In these experiments, INH did not decrease the effect of BCG on local tumor growth. However, the intratumor injection of BCG in rats receiving INH systematically was associated with better survival and smaller tumor volumes compared to the intratumor injection of BCG alone. |
| doi_str_mv | 10.1093/jnci/58.2.367 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_83830307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>83830307</sourcerecordid><originalsourceid>FETCH-LOGICAL-i243t-258ef94db6631c9b00e941b797565d55962e5c5e9d588d0585bb83e2fdc420873</originalsourceid><addsrcrecordid>eNo9j0tLAzEUhYP4qtWlOxezcjdtnpNkWdvaKRakoCBuwkySwdTOTJ1kwPrrjbR4F_dc-M45cAG4RXCEoCTjTaPdmIkRHpGMn4ABohlMMYLsFAwgxDwVgtNLcOX9BsaRmF6Ac4Ki0gHI51VldUjaKln6tnG6DS7uZKKdSfK96YofZ2zSNkn4sMmyCV0R-rrt4rmJORdBjD5MF9fgrCq23t4cdQheH-cv0zxdPS-W08kqdZiSkGImbCWpKbOMIC1LCK2kqOSSs4wZxmSGLdPMSsOEMJAJVpaCWFwZTTEUnAzB_aF317VfvfVB1c5ru90WjW17rwQRBBL4Z7w7GvuytkbtOlcX3V4dPo84PWDng_3-p0X3qTJOOFP527uCEK3XaPakOPkFrUpntA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83830307</pqid></control><display><type>article</type><title>Effect of Isonicotinic Acid Hydrazide on the Intratumor Injection of BCG</title><source>Oxford University Press Journals Digital Archive legacy</source><source>MEDLINE</source><creator>Sparks, Frank C. ; Albert, N. Erick ; Breeding, James H.</creator><creatorcontrib>Sparks, Frank C. ; Albert, N. Erick ; Breeding, James H.</creatorcontrib><description>Rats with established subcutaneous tumors were treated by repeated intratumor injections of BCG over a 5-week period. Isonicotinic acid hydrazide (INH) was given to some rats to determine if this drug decreased the effect of BCG on local tumor growth. INH alone had no effect on either survival or tumor volume. Rats treated with either BCG or BCG and INH had prolonged survivals and smaller tumor volumes than did control rats. In these experiments, INH did not decrease the effect of BCG on local tumor growth. However, the intratumor injection of BCG in rats receiving INH systematically was associated with better survival and smaller tumor volumes compared to the intratumor injection of BCG alone.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/58.2.367</identifier><identifier>PMID: 319244</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adenocarcinoma - immunology ; Adenocarcinoma - therapy ; Animals ; BCG Vaccine ; Immunity, Cellular - drug effects ; Immunotherapy ; Injections ; Isoniazid - pharmacology ; Isoniazid - therapeutic use ; Mammary Neoplasms, Experimental - immunology ; Mammary Neoplasms, Experimental - therapy ; Mycobacterium bovis - immunology ; Rats</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1977-02, Vol.58 (2), p.367-368</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/319244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sparks, Frank C.</creatorcontrib><creatorcontrib>Albert, N. Erick</creatorcontrib><creatorcontrib>Breeding, James H.</creatorcontrib><title>Effect of Isonicotinic Acid Hydrazide on the Intratumor Injection of BCG</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>Rats with established subcutaneous tumors were treated by repeated intratumor injections of BCG over a 5-week period. Isonicotinic acid hydrazide (INH) was given to some rats to determine if this drug decreased the effect of BCG on local tumor growth. INH alone had no effect on either survival or tumor volume. Rats treated with either BCG or BCG and INH had prolonged survivals and smaller tumor volumes than did control rats. In these experiments, INH did not decrease the effect of BCG on local tumor growth. However, the intratumor injection of BCG in rats receiving INH systematically was associated with better survival and smaller tumor volumes compared to the intratumor injection of BCG alone.</description><subject>Adenocarcinoma - immunology</subject><subject>Adenocarcinoma - therapy</subject><subject>Animals</subject><subject>BCG Vaccine</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunotherapy</subject><subject>Injections</subject><subject>Isoniazid - pharmacology</subject><subject>Isoniazid - therapeutic use</subject><subject>Mammary Neoplasms, Experimental - immunology</subject><subject>Mammary Neoplasms, Experimental - therapy</subject><subject>Mycobacterium bovis - immunology</subject><subject>Rats</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0tLAzEUhYP4qtWlOxezcjdtnpNkWdvaKRakoCBuwkySwdTOTJ1kwPrrjbR4F_dc-M45cAG4RXCEoCTjTaPdmIkRHpGMn4ABohlMMYLsFAwgxDwVgtNLcOX9BsaRmF6Ac4Ki0gHI51VldUjaKln6tnG6DS7uZKKdSfK96YofZ2zSNkn4sMmyCV0R-rrt4rmJORdBjD5MF9fgrCq23t4cdQheH-cv0zxdPS-W08kqdZiSkGImbCWpKbOMIC1LCK2kqOSSs4wZxmSGLdPMSsOEMJAJVpaCWFwZTTEUnAzB_aF317VfvfVB1c5ru90WjW17rwQRBBL4Z7w7GvuytkbtOlcX3V4dPo84PWDng_3-p0X3qTJOOFP527uCEK3XaPakOPkFrUpntA</recordid><startdate>197702</startdate><enddate>197702</enddate><creator>Sparks, Frank C.</creator><creator>Albert, N. Erick</creator><creator>Breeding, James H.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197702</creationdate><title>Effect of Isonicotinic Acid Hydrazide on the Intratumor Injection of BCG</title><author>Sparks, Frank C. ; Albert, N. Erick ; Breeding, James H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i243t-258ef94db6631c9b00e941b797565d55962e5c5e9d588d0585bb83e2fdc420873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adenocarcinoma - immunology</topic><topic>Adenocarcinoma - therapy</topic><topic>Animals</topic><topic>BCG Vaccine</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunotherapy</topic><topic>Injections</topic><topic>Isoniazid - pharmacology</topic><topic>Isoniazid - therapeutic use</topic><topic>Mammary Neoplasms, Experimental - immunology</topic><topic>Mammary Neoplasms, Experimental - therapy</topic><topic>Mycobacterium bovis - immunology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sparks, Frank C.</creatorcontrib><creatorcontrib>Albert, N. Erick</creatorcontrib><creatorcontrib>Breeding, James H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sparks, Frank C.</au><au>Albert, N. Erick</au><au>Breeding, James H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Isonicotinic Acid Hydrazide on the Intratumor Injection of BCG</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1977-02</date><risdate>1977</risdate><volume>58</volume><issue>2</issue><spage>367</spage><epage>368</epage><pages>367-368</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>Rats with established subcutaneous tumors were treated by repeated intratumor injections of BCG over a 5-week period. Isonicotinic acid hydrazide (INH) was given to some rats to determine if this drug decreased the effect of BCG on local tumor growth. INH alone had no effect on either survival or tumor volume. Rats treated with either BCG or BCG and INH had prolonged survivals and smaller tumor volumes than did control rats. In these experiments, INH did not decrease the effect of BCG on local tumor growth. However, the intratumor injection of BCG in rats receiving INH systematically was associated with better survival and smaller tumor volumes compared to the intratumor injection of BCG alone.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>319244</pmid><doi>10.1093/jnci/58.2.367</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1977-02, Vol.58 (2), p.367-368 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83830307 |
| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Adenocarcinoma - immunology Adenocarcinoma - therapy Animals BCG Vaccine Immunity, Cellular - drug effects Immunotherapy Injections Isoniazid - pharmacology Isoniazid - therapeutic use Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - therapy Mycobacterium bovis - immunology Rats |
| title | Effect of Isonicotinic Acid Hydrazide on the Intratumor Injection of BCG |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T07%3A37%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Isonicotinic%20Acid%20Hydrazide%20on%20the%20Intratumor%20Injection%20of%20BCG&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=Sparks,%20Frank%20C.&rft.date=1977-02&rft.volume=58&rft.issue=2&rft.spage=367&rft.epage=368&rft.pages=367-368&rft.issn=0027-8874&rft.eissn=1460-2105&rft_id=info:doi/10.1093/jnci/58.2.367&rft_dat=%3Cproquest_pubme%3E83830307%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83830307&rft_id=info:pmid/319244&rfr_iscdi=true |