Observations on the pathogenesis and management of pulmonary hypertension
Experimental subclavian-pulmonary and aortapulmonary anastomoses were performed in attempts to produce progressively increasing pulmonary vascular changes and to observe their sequential development. At six weeks after anastomosis there was medial hypertrophy, at eight weeks total involvement of the...
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Veröffentlicht in: | The American journal of surgery 1978-03, Vol.135 (3), p.302-311 |
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description | Experimental subclavian-pulmonary and aortapulmonary anastomoses were performed in attempts to produce progressively increasing pulmonary vascular changes and to observe their sequential development. At six weeks after anastomosis there was medial hypertrophy, at eight weeks total involvement of the artery, and at eleven weeks severe pulmonary vascular disease, total decrease in the number of capillaries, and complete obstruction of the lumen. These pathologic changes are compared with the normal course of events in the fetal and postnatal lung. A series of patients with patent ductus arteriosus, single ventricle, and a large ventricular septal defect were studied and categorized into three phases according to the severity of their clinical symptoms. A method for producing pulmonary artery stenosis in the laboratory as applied to a three month old infant is discussed. |
doi_str_mv | 10.1016/0002-9610(78)90057-0 |
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A method for producing pulmonary artery stenosis in the laboratory as applied to a three month old infant is discussed.</description><subject>Animals</subject><subject>Aorta - surgery</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - complications</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Hypertension, Pulmonary - surgery</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lung - embryology</subject><subject>Lung - growth & development</subject><subject>Pulmonary Artery - physiopathology</subject><subject>Pulmonary Artery - surgery</subject><subject>Subclavian Artery - surgery</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAQxy3EqxS-QYdMCIaAHSeOsyChikelSl1gthz73AYldrDdSv32pKRiZDqd_g_d_RCaEfxAMGGPGOMsrRjBdyW_rzAuyhSfoAnhZZUSzukpmvxZLtFVCF_DSkhOL9A5yxglZIIWqzqA38nYOBsSZ5O4gaSXcePWYCE0IZFWJ520cg0d2Jg4k_TbtnNW-n2y2ffgI9gwpK_RmZFtgJvjnKLP15eP-Xu6XL0t5s_LVNGCxTQnBkxBoDZUZZTrkukq05pLkmteqZpThllRV9IYCUxirYrCGAa1JLwuMadTdDv29t59byFE0TVBQdtKC24bBKec4iwjgzEfjcq7EDwY0fumG84WBIsDQHGgIw50RMnFL0CBh9js2L-tO9B_oZHYID-NMgw_7hrwIqgGrALdeFBRaNf83_8DJr-A7g</recordid><startdate>197803</startdate><enddate>197803</enddate><creator>Muller, William H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197803</creationdate><title>Observations on the pathogenesis and management of pulmonary hypertension</title><author>Muller, William H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-41fef51ebf3c238d76d92dd8a14d89cb836065b9affae6a0dc55ff6eba18b7083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Aorta - surgery</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - complications</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Hypertension, Pulmonary - surgery</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lung - embryology</topic><topic>Lung - growth & development</topic><topic>Pulmonary Artery - physiopathology</topic><topic>Pulmonary Artery - surgery</topic><topic>Subclavian Artery - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muller, William H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muller, William H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Observations on the pathogenesis and management of pulmonary hypertension</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1978-03</date><risdate>1978</risdate><volume>135</volume><issue>3</issue><spage>302</spage><epage>311</epage><pages>302-311</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Experimental subclavian-pulmonary and aortapulmonary anastomoses were performed in attempts to produce progressively increasing pulmonary vascular changes and to observe their sequential development. 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subjects | Animals Aorta - surgery Child Child, Preschool Disease Models, Animal Dogs Humans Hypertension, Pulmonary - complications Hypertension, Pulmonary - physiopathology Hypertension, Pulmonary - surgery Infant Infant, Newborn Lung - embryology Lung - growth & development Pulmonary Artery - physiopathology Pulmonary Artery - surgery Subclavian Artery - surgery |
title | Observations on the pathogenesis and management of pulmonary hypertension |
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