Regional myocardial perfusion abnormalities on xenon-133 imaging in patients with angina pectoris and normal coronary arteries
With use of semiselective xenon-133 injections and gamma camera recording, myocardial scintigrams were obtained in a series of 20 patients with angina pectoris, abnormal exercise electrocardiograms and normal coronary arteries. Ten patients (Group I) exhibited localized perfusion defects and the oth...
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| Veröffentlicht in: | The American journal of cardiology 1977, Vol.39 (3), p.355-359 |
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| container_title | The American journal of cardiology |
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| creator | Korhola, Ossi Valle, Matti Frick, M. Heikki Wiljasalo, Mauri Riihimäki, Esko |
| description | With use of semiselective xenon-133 injections and gamma camera recording, myocardial scintigrams were obtained in a series of 20 patients with angina pectoris, abnormal exercise electrocardiograms and normal coronary arteries. Ten patients (Group I) exhibited localized perfusion defects and the other 10 (Group II) a homogeneous uptake of the tracer. Group I was characterized by more past myocardial infarctions and, most significantly, by male preponderance (
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| doi_str_mv | 10.1016/S0002-9149(77)80088-X |
| format | Article |
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P <0.001). Computer analysis of regional xenon-133 washout curves revealed that every patient in Group I had a reduced flow rate in the area of the perfusion defect (
P <0.001). A comparison of this group with 26 patients with similarly abnormal scintigrams but coronary arterial obstruction revealed that myocardial perfusion was 16 to 18 percent greater in the group with normal coronary arteries. In three patients of this group, myocardial perfusion rates were not augmented by atrial pacing in contrast to the response in patients with coronary arterial obstruction.
The data demonstrated localized perfusion abnormalities in half of the patients with angina pectoris and normal coronary arteries and constitute evidence that a metabolic disorder is not the sole mechanism for ischemia in this syndrome.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(77)80088-X</identifier><identifier>PMID: 842456</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Angina Pectoris - diagnosis ; Blood Flow Velocity ; Coronary Circulation ; Coronary Disease - diagnosis ; Electrocardiography ; Exercise Test ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction - diagnosis ; Radionuclide Imaging ; Xenon Radioisotopes</subject><ispartof>The American journal of cardiology, 1977, Vol.39 (3), p.355-359</ispartof><rights>1977 Dun • Donnelley Publishing Corporation 666 Fifth Avenue, New York, New York 10019 All rights reserved</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c274t-308c24faff745daf4db0e18815c9b34e1332fa46f2f586167cfd30217856160b3</citedby><cites>FETCH-LOGICAL-c274t-308c24faff745daf4db0e18815c9b34e1332fa46f2f586167cfd30217856160b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9149(77)80088-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/842456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Korhola, Ossi</creatorcontrib><creatorcontrib>Valle, Matti</creatorcontrib><creatorcontrib>Frick, M. Heikki</creatorcontrib><creatorcontrib>Wiljasalo, Mauri</creatorcontrib><creatorcontrib>Riihimäki, Esko</creatorcontrib><title>Regional myocardial perfusion abnormalities on xenon-133 imaging in patients with angina pectoris and normal coronary arteries</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>With use of semiselective xenon-133 injections and gamma camera recording, myocardial scintigrams were obtained in a series of 20 patients with angina pectoris, abnormal exercise electrocardiograms and normal coronary arteries. Ten patients (Group I) exhibited localized perfusion defects and the other 10 (Group II) a homogeneous uptake of the tracer. Group I was characterized by more past myocardial infarctions and, most significantly, by male preponderance (
P <0.001). Computer analysis of regional xenon-133 washout curves revealed that every patient in Group I had a reduced flow rate in the area of the perfusion defect (
P <0.001). A comparison of this group with 26 patients with similarly abnormal scintigrams but coronary arterial obstruction revealed that myocardial perfusion was 16 to 18 percent greater in the group with normal coronary arteries. In three patients of this group, myocardial perfusion rates were not augmented by atrial pacing in contrast to the response in patients with coronary arterial obstruction.
The data demonstrated localized perfusion abnormalities in half of the patients with angina pectoris and normal coronary arteries and constitute evidence that a metabolic disorder is not the sole mechanism for ischemia in this syndrome.</description><subject>Adult</subject><subject>Angina Pectoris - diagnosis</subject><subject>Blood Flow Velocity</subject><subject>Coronary Circulation</subject><subject>Coronary Disease - diagnosis</subject><subject>Electrocardiography</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Radionuclide Imaging</subject><subject>Xenon Radioisotopes</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi3UQrcL_6CVfEJwCLVjJ3ZOCCG-JCQkaCVuluPYW6PE3toJ7V747R0I2isne2beeWfmQeg7JSeU0PrHAyGkLBrKmyMhjiUhUhaPO2hBpWgK2lD2CS22ki_oa85PEFJa1XtoV_KSV_UCvdzblY9B93jYRKNT5-G7tslNGdJYtyGmQfd-9DZjSPyzIYaCMob9oFc-rLAPeK2hHMaM__rxN9YB8hpMzBiTzxB3eHbBJiaYlTZYp9EmsNxHn53usz14f5fo1-XFz_Pr4vbu6ub87LYwpeBjwYg0JXfaOcGrTjvetcRSKWllmpZxC_uUTvPala6SNa2FcR0jJRWygoi0bIkOZ991in8mm0c1-Gxs3-tg45SVZLIEOQNhNQtNijkn69Q6waVpoyhRr9jVG3b1ylQJod6wq0fo-_Y-YGoH2227Zs5QPp3LFo589japbACZsZ1PwEl10X8w4D8yNZRf</recordid><startdate>1977</startdate><enddate>1977</enddate><creator>Korhola, Ossi</creator><creator>Valle, Matti</creator><creator>Frick, M. Heikki</creator><creator>Wiljasalo, Mauri</creator><creator>Riihimäki, Esko</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1977</creationdate><title>Regional myocardial perfusion abnormalities on xenon-133 imaging in patients with angina pectoris and normal coronary arteries</title><author>Korhola, Ossi ; Valle, Matti ; Frick, M. Heikki ; Wiljasalo, Mauri ; Riihimäki, Esko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-308c24faff745daf4db0e18815c9b34e1332fa46f2f586167cfd30217856160b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adult</topic><topic>Angina Pectoris - diagnosis</topic><topic>Blood Flow Velocity</topic><topic>Coronary Circulation</topic><topic>Coronary Disease - diagnosis</topic><topic>Electrocardiography</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Radionuclide Imaging</topic><topic>Xenon Radioisotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Korhola, Ossi</creatorcontrib><creatorcontrib>Valle, Matti</creatorcontrib><creatorcontrib>Frick, M. Heikki</creatorcontrib><creatorcontrib>Wiljasalo, Mauri</creatorcontrib><creatorcontrib>Riihimäki, Esko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korhola, Ossi</au><au>Valle, Matti</au><au>Frick, M. Heikki</au><au>Wiljasalo, Mauri</au><au>Riihimäki, Esko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional myocardial perfusion abnormalities on xenon-133 imaging in patients with angina pectoris and normal coronary arteries</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1977</date><risdate>1977</risdate><volume>39</volume><issue>3</issue><spage>355</spage><epage>359</epage><pages>355-359</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>With use of semiselective xenon-133 injections and gamma camera recording, myocardial scintigrams were obtained in a series of 20 patients with angina pectoris, abnormal exercise electrocardiograms and normal coronary arteries. Ten patients (Group I) exhibited localized perfusion defects and the other 10 (Group II) a homogeneous uptake of the tracer. Group I was characterized by more past myocardial infarctions and, most significantly, by male preponderance (
P <0.001). Computer analysis of regional xenon-133 washout curves revealed that every patient in Group I had a reduced flow rate in the area of the perfusion defect (
P <0.001). A comparison of this group with 26 patients with similarly abnormal scintigrams but coronary arterial obstruction revealed that myocardial perfusion was 16 to 18 percent greater in the group with normal coronary arteries. In three patients of this group, myocardial perfusion rates were not augmented by atrial pacing in contrast to the response in patients with coronary arterial obstruction.
The data demonstrated localized perfusion abnormalities in half of the patients with angina pectoris and normal coronary arteries and constitute evidence that a metabolic disorder is not the sole mechanism for ischemia in this syndrome.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>842456</pmid><doi>10.1016/S0002-9149(77)80088-X</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 1977, Vol.39 (3), p.355-359 |
| issn | 0002-9149 1879-1913 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Angina Pectoris - diagnosis Blood Flow Velocity Coronary Circulation Coronary Disease - diagnosis Electrocardiography Exercise Test Female Humans Male Middle Aged Myocardial Infarction - diagnosis Radionuclide Imaging Xenon Radioisotopes |
| title | Regional myocardial perfusion abnormalities on xenon-133 imaging in patients with angina pectoris and normal coronary arteries |
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