Localization of glomerular 'deposits' in Henoch-Schönlein nephritis
Twenty‐five renal biopsies from patients with Henoch‐Schönlein nephritis were examined using light microscopy, immunofluorescence, I μm plastic‐embedded sections and electron microscopy. The I μm plastic‐embedded sections and electron microscopy showed deposits in mesangial, subendothelial and subep...
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| Veröffentlicht in: | Histopathology 1977-03, Vol.1 (2), p.93-104 |
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| creator | HEATON, JULIET M. TURNER, D. R. CAMERON, J. S. |
| description | Twenty‐five renal biopsies from patients with Henoch‐Schönlein nephritis were examined using light microscopy, immunofluorescence, I μm plastic‐embedded sections and electron microscopy. The I μm plastic‐embedded sections and electron microscopy showed deposits in mesangial, subendothelial and subepithelial sites. Some of the latter were very large and similar to those which have been described as ‘humps’ in acute proliferative glomerulonephritis. Immunofluorescence showed the mesangial deposition of IgG, IgA and C3 with extension into a peripheral position in some cases. Fibrin was frequently found associated with crescents. The case for Henoch‐Schönlein disease being mediated, in part at least, by immune complex deposition, is presented. |
| doi_str_mv | 10.1111/j.1365-2559.1977.tb01648.x |
| format | Article |
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R. ; CAMERON, J. S.</creator><creatorcontrib>HEATON, JULIET M. ; TURNER, D. R. ; CAMERON, J. S.</creatorcontrib><description>Twenty‐five renal biopsies from patients with Henoch‐Schönlein nephritis were examined using light microscopy, immunofluorescence, I μm plastic‐embedded sections and electron microscopy. The I μm plastic‐embedded sections and electron microscopy showed deposits in mesangial, subendothelial and subepithelial sites. Some of the latter were very large and similar to those which have been described as ‘humps’ in acute proliferative glomerulonephritis. Immunofluorescence showed the mesangial deposition of IgG, IgA and C3 with extension into a peripheral position in some cases. Fibrin was frequently found associated with crescents. The case for Henoch‐Schönlein disease being mediated, in part at least, by immune complex deposition, is presented.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.1977.tb01648.x</identifier><identifier>PMID: 680651</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Complement System Proteins - analysis ; Endothelium - ultrastructure ; Epithelium - ultrastructure ; glomerular deposits ; glomerulonephritis ; Glomerulonephritis - immunology ; Glomerulonephritis - pathology ; Henoch-Schönlein nephritis ; Humans ; Immunoglobulins - analysis ; Kidney Glomerulus - immunology ; Kidney Glomerulus - ultrastructure ; Purpura, Schoenlein-Henoch - immunology ; Purpura, Schoenlein-Henoch - pathology</subject><ispartof>Histopathology, 1977-03, Vol.1 (2), p.93-104</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5003-d8bfbc85a3cf24dab859c6802369a255828566f61bef74933e8e179d5f5c8bad3</citedby><cites>FETCH-LOGICAL-c5003-d8bfbc85a3cf24dab859c6802369a255828566f61bef74933e8e179d5f5c8bad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2559.1977.tb01648.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2559.1977.tb01648.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/680651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HEATON, JULIET M.</creatorcontrib><creatorcontrib>TURNER, D. R.</creatorcontrib><creatorcontrib>CAMERON, J. S.</creatorcontrib><title>Localization of glomerular 'deposits' in Henoch-Schönlein nephritis</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Twenty‐five renal biopsies from patients with Henoch‐Schönlein nephritis were examined using light microscopy, immunofluorescence, I μm plastic‐embedded sections and electron microscopy. The I μm plastic‐embedded sections and electron microscopy showed deposits in mesangial, subendothelial and subepithelial sites. Some of the latter were very large and similar to those which have been described as ‘humps’ in acute proliferative glomerulonephritis. Immunofluorescence showed the mesangial deposition of IgG, IgA and C3 with extension into a peripheral position in some cases. Fibrin was frequently found associated with crescents. The case for Henoch‐Schönlein disease being mediated, in part at least, by immune complex deposition, is presented.</description><subject>Complement System Proteins - analysis</subject><subject>Endothelium - ultrastructure</subject><subject>Epithelium - ultrastructure</subject><subject>glomerular deposits</subject><subject>glomerulonephritis</subject><subject>Glomerulonephritis - immunology</subject><subject>Glomerulonephritis - pathology</subject><subject>Henoch-Schönlein nephritis</subject><subject>Humans</subject><subject>Immunoglobulins - analysis</subject><subject>Kidney Glomerulus - immunology</subject><subject>Kidney Glomerulus - ultrastructure</subject><subject>Purpura, Schoenlein-Henoch - immunology</subject><subject>Purpura, Schoenlein-Henoch - pathology</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtOwzAQhi3EqxRuwCJiQVcJdlw7DhIL1EJbqQKhgmBnOY5DXdK42KloORgX4GK4StU9sxlp_vnn8QFwgWCEfFzNIoQpCWNC0gilSRLVGUS0y6LVHmjtpH3QghimoZeSY3Di3AxClOA4PgKHlEFKUAv0x0aKUn-LWpsqMEXwXpq5sstS2KCTq4VxunadQFfBUFVGTsOJnP7-VKXylUotplbX2p2Cg0KUTp1tcxu83N8994bh-HEw6t2OQ0kgxGHOsiKTjAgsi7ibi4yRVPpDYkxT4Q9mMSOUFhRlqki6KcaKKZSkOSmIZJnIcRtcNnMX1nwulav5XDupylJUyiwdZ5jFiMbEN143jdIa56wq-MLqubBrjiDfEOQzvsHEN5j4hiDfEuQrbz7fbllmc5XvrA0yL9808pcu1fofg_lwNPFPtUHY-LWr1WrnF_aD0wQnhL8-DHg_JU_PjL35l_4AE9WQVA</recordid><startdate>197703</startdate><enddate>197703</enddate><creator>HEATON, JULIET M.</creator><creator>TURNER, D. R.</creator><creator>CAMERON, J. S.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197703</creationdate><title>Localization of glomerular 'deposits' in Henoch-Schönlein nephritis</title><author>HEATON, JULIET M. ; TURNER, D. R. ; CAMERON, J. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5003-d8bfbc85a3cf24dab859c6802369a255828566f61bef74933e8e179d5f5c8bad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Complement System Proteins - analysis</topic><topic>Endothelium - ultrastructure</topic><topic>Epithelium - ultrastructure</topic><topic>glomerular deposits</topic><topic>glomerulonephritis</topic><topic>Glomerulonephritis - immunology</topic><topic>Glomerulonephritis - pathology</topic><topic>Henoch-Schönlein nephritis</topic><topic>Humans</topic><topic>Immunoglobulins - analysis</topic><topic>Kidney Glomerulus - immunology</topic><topic>Kidney Glomerulus - ultrastructure</topic><topic>Purpura, Schoenlein-Henoch - immunology</topic><topic>Purpura, Schoenlein-Henoch - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HEATON, JULIET M.</creatorcontrib><creatorcontrib>TURNER, D. R.</creatorcontrib><creatorcontrib>CAMERON, J. S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HEATON, JULIET M.</au><au>TURNER, D. R.</au><au>CAMERON, J. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization of glomerular 'deposits' in Henoch-Schönlein nephritis</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>1977-03</date><risdate>1977</risdate><volume>1</volume><issue>2</issue><spage>93</spage><epage>104</epage><pages>93-104</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Twenty‐five renal biopsies from patients with Henoch‐Schönlein nephritis were examined using light microscopy, immunofluorescence, I μm plastic‐embedded sections and electron microscopy. The I μm plastic‐embedded sections and electron microscopy showed deposits in mesangial, subendothelial and subepithelial sites. Some of the latter were very large and similar to those which have been described as ‘humps’ in acute proliferative glomerulonephritis. Immunofluorescence showed the mesangial deposition of IgG, IgA and C3 with extension into a peripheral position in some cases. Fibrin was frequently found associated with crescents. The case for Henoch‐Schönlein disease being mediated, in part at least, by immune complex deposition, is presented.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>680651</pmid><doi>10.1111/j.1365-2559.1977.tb01648.x</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0309-0167 |
| ispartof | Histopathology, 1977-03, Vol.1 (2), p.93-104 |
| issn | 0309-0167 1365-2559 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Complement System Proteins - analysis Endothelium - ultrastructure Epithelium - ultrastructure glomerular deposits glomerulonephritis Glomerulonephritis - immunology Glomerulonephritis - pathology Henoch-Schönlein nephritis Humans Immunoglobulins - analysis Kidney Glomerulus - immunology Kidney Glomerulus - ultrastructure Purpura, Schoenlein-Henoch - immunology Purpura, Schoenlein-Henoch - pathology |
| title | Localization of glomerular 'deposits' in Henoch-Schönlein nephritis |
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