Kinetic Spectrophotometric Study of Effect of Triazolopyrazines on p-Benzoquinone Complexes
The effect of adding triazolopyrazines to a p-benzoqui-none-proline system and a p-benzoquinone-histamine system was studied by observing the kinetics of the spectral changes and analyzing the results using digital simulation methods. Below 35°, the major effect was that the triazolopyrazine compete...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1977-02, Vol.66 (2), p.205-208 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Moxon, G.H. Slifkin, M.A. |
| description | The effect of adding triazolopyrazines to a p-benzoqui-none-proline system and a p-benzoquinone-histamine system was studied by observing the kinetics of the spectral changes and analyzing the results using digital simulation methods. Below 35°, the major effect was that the triazolopyrazine competed with the electron donors for the acceptors to form complexes. Above 35°, there was predominantly a chemical interaction between the triazolopyrazine and the acceptors. A separate experiment showed that the triazolopyrazine interacted with p-benzoquinone to form a complex initially but that a chemical interaction took place later. |
| doi_str_mv | 10.1002/jps.2600660218 |
| format | Article |
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Below 35°, the major effect was that the triazolopyrazine competed with the electron donors for the acceptors to form complexes. Above 35°, there was predominantly a chemical interaction between the triazolopyrazine and the acceptors. A separate experiment showed that the triazolopyrazine interacted with p-benzoquinone to form a complex initially but that a chemical interaction took place later.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600660218</identifier><identifier>PMID: 839416</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Chelating Agents ; Chemical Phenomena ; Chemistry ; Complexes-p-benzoquinone with proline and histamine ; Complexes—p-benzoquinone with proline and histamine effect of various triazolopyrazines, kinetic spectrophotometric study ; effect of triazolopyrazines on complexes of p-benzoquinone with proline and histamine ; effect of various triazolopyrazines ; effect on complexes of p-benzoquinone with proline and histamine ; Histamine ; kinetic spectrophotometric study ; Kinetics ; p-Benzoquinone complexes-with proline and histamine ; p-Benzoquinone complexes—with proline and histamine effect of various triazolopyrazines, kinetic spectrophotometric study ; Proline ; Pyrazines ; Quinones - analysis ; Spectrophotometry ; Spectrophotometry-kinetic study ; Spectrophotometry—kinetic study effect of triazolopyrazines on complexes of p-benzoquinone with proline and histamine ; Structure-activity relationships-various triazolopyrazines ; Structure-activity relationships—various triazolopyrazines effect on complexes of p-benzoquinone with proline and histamine ; substituted-effect on complexes of p-benzoquinone with proline and histamine ; Thermodynamics ; Time Factors ; Triazoles ; Triazolopyrazines ; Triazolopyrazines substituted—effect on complexes of p-benzoquinone with proline and histamine, kinetic spectrophotometric study</subject><ispartof>Journal of pharmaceutical sciences, 1977-02, Vol.66 (2), p.205-208</ispartof><rights>1977 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1977 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2968-a1f41014ee34dc25b587c58c291aaa0075b8bdef4692462fa9e16462ac7da4453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600660218$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600660218$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/839416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moxon, G.H.</creatorcontrib><creatorcontrib>Slifkin, M.A.</creatorcontrib><title>Kinetic Spectrophotometric Study of Effect of Triazolopyrazines on p-Benzoquinone Complexes</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The effect of adding triazolopyrazines to a p-benzoqui-none-proline system and a p-benzoquinone-histamine system was studied by observing the kinetics of the spectral changes and analyzing the results using digital simulation methods. Below 35°, the major effect was that the triazolopyrazine competed with the electron donors for the acceptors to form complexes. Above 35°, there was predominantly a chemical interaction between the triazolopyrazine and the acceptors. A separate experiment showed that the triazolopyrazine interacted with p-benzoquinone to form a complex initially but that a chemical interaction took place later.</description><subject>Chelating Agents</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Complexes-p-benzoquinone with proline and histamine</subject><subject>Complexes—p-benzoquinone with proline and histamine effect of various triazolopyrazines, kinetic spectrophotometric study</subject><subject>effect of triazolopyrazines on complexes of p-benzoquinone with proline and histamine</subject><subject>effect of various triazolopyrazines</subject><subject>effect on complexes of p-benzoquinone with proline and histamine</subject><subject>Histamine</subject><subject>kinetic spectrophotometric study</subject><subject>Kinetics</subject><subject>p-Benzoquinone complexes-with proline and histamine</subject><subject>p-Benzoquinone complexes—with proline and histamine effect of various triazolopyrazines, kinetic spectrophotometric study</subject><subject>Proline</subject><subject>Pyrazines</subject><subject>Quinones - analysis</subject><subject>Spectrophotometry</subject><subject>Spectrophotometry-kinetic study</subject><subject>Spectrophotometry—kinetic study effect of triazolopyrazines on complexes of p-benzoquinone with proline and histamine</subject><subject>Structure-activity relationships-various triazolopyrazines</subject><subject>Structure-activity relationships—various triazolopyrazines effect on complexes of p-benzoquinone with proline and histamine</subject><subject>substituted-effect on complexes of p-benzoquinone with proline and histamine</subject><subject>Thermodynamics</subject><subject>Time Factors</subject><subject>Triazoles</subject><subject>Triazolopyrazines</subject><subject>Triazolopyrazines substituted—effect on complexes of p-benzoquinone with proline and histamine, kinetic spectrophotometric study</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9P2zAcxa2JDTq2604ccuKWznZsxzlCKS2_tkmwceBguc43wpDEwU6B9q-fqyAQh2knf-X3eU9fPyP0jeAxwZh-v-vCmAqMhcCUyA9oRDjFqcAk30KjCNA046zYQZ9DuMMRw5xvo08yKxgRI3RzZlvorUkuOzC9d92t610Dvd9c9ctylbgqmVZVFDfTlbd67WrXrbxeR2dIXJt06SG0a_ewtK1rIZm4pqvhGcIX9LHSdYCvL-cu-n08vZrM0_Ofs5PJwXlqaCFkqknFCCYMIGOloXzBZW64jCLRWmOc84VclFAxUVAmaKULICIO2uSlZoxnu2h_yO18XAJCrxobDNS1bsEtg5KZpDhaIzgeQONdCB4q1XnbaL9SBKtNmSqWqd7KjIa9l-TlooHyFR_ai3IxyE-2htV_wtTpr8t30engtaGH51ev9vdK5FnO1fWPmTqaX8yO57NT9SfycuAhNvlowatgLLQGSuvj56jS2X-94i_AyaOe</recordid><startdate>197702</startdate><enddate>197702</enddate><creator>Moxon, G.H.</creator><creator>Slifkin, M.A.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197702</creationdate><title>Kinetic Spectrophotometric Study of Effect of Triazolopyrazines on p-Benzoquinone Complexes</title><author>Moxon, G.H. ; Slifkin, M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2968-a1f41014ee34dc25b587c58c291aaa0075b8bdef4692462fa9e16462ac7da4453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Chelating Agents</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Complexes-p-benzoquinone with proline and histamine</topic><topic>Complexes—p-benzoquinone with proline and histamine effect of various triazolopyrazines, kinetic spectrophotometric study</topic><topic>effect of triazolopyrazines on complexes of p-benzoquinone with proline and histamine</topic><topic>effect of various triazolopyrazines</topic><topic>effect on complexes of p-benzoquinone with proline and histamine</topic><topic>Histamine</topic><topic>kinetic spectrophotometric study</topic><topic>Kinetics</topic><topic>p-Benzoquinone complexes-with proline and histamine</topic><topic>p-Benzoquinone complexes—with proline and histamine effect of various triazolopyrazines, kinetic spectrophotometric study</topic><topic>Proline</topic><topic>Pyrazines</topic><topic>Quinones - analysis</topic><topic>Spectrophotometry</topic><topic>Spectrophotometry-kinetic study</topic><topic>Spectrophotometry—kinetic study effect of triazolopyrazines on complexes of p-benzoquinone with proline and histamine</topic><topic>Structure-activity relationships-various triazolopyrazines</topic><topic>Structure-activity relationships—various triazolopyrazines effect on complexes of p-benzoquinone with proline and histamine</topic><topic>substituted-effect on complexes of p-benzoquinone with proline and histamine</topic><topic>Thermodynamics</topic><topic>Time Factors</topic><topic>Triazoles</topic><topic>Triazolopyrazines</topic><topic>Triazolopyrazines substituted—effect on complexes of p-benzoquinone with proline and histamine, kinetic spectrophotometric study</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moxon, G.H.</creatorcontrib><creatorcontrib>Slifkin, M.A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moxon, G.H.</au><au>Slifkin, M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetic Spectrophotometric Study of Effect of Triazolopyrazines on p-Benzoquinone Complexes</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1977-02</date><risdate>1977</risdate><volume>66</volume><issue>2</issue><spage>205</spage><epage>208</epage><pages>205-208</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The effect of adding triazolopyrazines to a p-benzoqui-none-proline system and a p-benzoquinone-histamine system was studied by observing the kinetics of the spectral changes and analyzing the results using digital simulation methods. Below 35°, the major effect was that the triazolopyrazine competed with the electron donors for the acceptors to form complexes. Above 35°, there was predominantly a chemical interaction between the triazolopyrazine and the acceptors. A separate experiment showed that the triazolopyrazine interacted with p-benzoquinone to form a complex initially but that a chemical interaction took place later.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>839416</pmid><doi>10.1002/jps.2600660218</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1977-02, Vol.66 (2), p.205-208 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Chelating Agents Chemical Phenomena Chemistry Complexes-p-benzoquinone with proline and histamine Complexes—p-benzoquinone with proline and histamine effect of various triazolopyrazines, kinetic spectrophotometric study effect of triazolopyrazines on complexes of p-benzoquinone with proline and histamine effect of various triazolopyrazines effect on complexes of p-benzoquinone with proline and histamine Histamine kinetic spectrophotometric study Kinetics p-Benzoquinone complexes-with proline and histamine p-Benzoquinone complexes—with proline and histamine effect of various triazolopyrazines, kinetic spectrophotometric study Proline Pyrazines Quinones - analysis Spectrophotometry Spectrophotometry-kinetic study Spectrophotometry—kinetic study effect of triazolopyrazines on complexes of p-benzoquinone with proline and histamine Structure-activity relationships-various triazolopyrazines Structure-activity relationships—various triazolopyrazines effect on complexes of p-benzoquinone with proline and histamine substituted-effect on complexes of p-benzoquinone with proline and histamine Thermodynamics Time Factors Triazoles Triazolopyrazines Triazolopyrazines substituted—effect on complexes of p-benzoquinone with proline and histamine, kinetic spectrophotometric study |
| title | Kinetic Spectrophotometric Study of Effect of Triazolopyrazines on p-Benzoquinone Complexes |
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