Regional intralymphatic infusion (ILI) of irradiated tumor cells with evidence of distant effects

A case of canine lymphoma with radiographically‐documented involvement of the para‐aortic nodes is reported. Intralymphatic infusions (ILI) of cultured irradiated autochthonous tumor cells to remote lymph node bearing areas were associated with a dramatic initial shrinkage of the para‐aortic lymphadenop‐athies. Three ILI timing schedules were used consecutively during a course of 10 treatments, allowing a comparison of responses in the same animal. The reported case suggests that a normal lymph node can be effectively “stimulated” by the same agent approximately every 3 weeks. A possible schedule for intralymphatic infusion is proposed for further investigation.