Antigenicity of the Major Polypeptides of Hepatitis B Surface Antigen (HBsAg)
The major polypeptides (P-1, P-2, and P-6) of HBsAg were isolated from purified preparations of 22-nm HBsAg particles, iodinated, and analyzed by double-antibody radioimmunoprecipitation assays for the presence of hepatitis B virus (HBV)-specific antigens. Each polypeptide fraction contained both gr...
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| Veröffentlicht in: | The Journal of immunology (1950) 1978-02, Vol.120 (2), p.520-525 |
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| container_title | The Journal of immunology (1950) |
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| creator | Shih, J. Wai-Kuo Tan, Peter L Gerin, John L |
| description | The major polypeptides (P-1, P-2, and P-6) of HBsAg were isolated from purified preparations of 22-nm HBsAg particles, iodinated, and analyzed by double-antibody radioimmunoprecipitation assays for the presence of hepatitis B virus (HBV)-specific antigens. Each polypeptide fraction contained both group (a) and subtype (d) specific determinants in common by virtue of their immunoreaction with antiserum to native HBsAg and antisera to the other structural polypeptides. The antigenic and structural similarities of the HBsAg polypeptides establish that they are not each unique gene products of the HBV genome. |
| doi_str_mv | 10.4049/jimmunol.120.2.520 |
| format | Article |
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The antigenic and structural similarities of the HBsAg polypeptides establish that they are not each unique gene products of the HBV genome.</description><subject>Antigens</subject><subject>Epitopes</subject><subject>Hepatitis B Surface Antigens - analysis</subject><subject>Hepatitis B virus - immunology</subject><subject>Humans</subject><subject>Peptides - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS1EBaXwA7DxCsEiYfzIw8u2AorUCiRgbTmJ3brKizhR1L8npQVWs5h77mgOQtcEfA5cPGxtUXRllfuEgk_9gMIJGpMgAC8MITxFYwBKPRKF0Tm6cG4LACFQfoZGEWeCjNFqWrZ2rUub2naHK4PbjcYrta0a_Fblu1rXrc20228Wulatba3DM_zeNUalGh9pfLeYuen6_hKNjMqdvjrOCfp8evyYL7zl6_PLfLr0UhqH4GWaEdAmIAnnjGfAYpFQpojJBI0yIxQkYSpCzmhEExZRiLnIuE6oIVQEhrAJuj301k311WnXysK6VOe5KnXVORmzePhUiCFID8G0qZxrtJF1YwvV7CQBuTcofw3KwaCkcjA4QDfH9i4pdPaH_Cj7v72x601vGy1dofJ8yBLZ9_1_zTeMtXnU</recordid><startdate>197802</startdate><enddate>197802</enddate><creator>Shih, J. 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The antigenic and structural similarities of the HBsAg polypeptides establish that they are not each unique gene products of the HBV genome.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>74391</pmid><doi>10.4049/jimmunol.120.2.520</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of immunology (1950), 1978-02, Vol.120 (2), p.520-525 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antigens Epitopes Hepatitis B Surface Antigens - analysis Hepatitis B virus - immunology Humans Peptides - immunology |
| title | Antigenicity of the Major Polypeptides of Hepatitis B Surface Antigen (HBsAg) |
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