Kinetics of Indomethacin Degradation I: Presence of Alkali
The kinetics of indomethacin degradation were followed in alkaline aqueous solutions at various temperatures between 20.1 and 40.7°. The apparent first‐order rate constants were evaluated from log absorbance versus time plots at λmax 318 nm. The primary salt effect was positive. The rate constant‐hy...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1977-01, Vol.66 (1), p.27-29 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Hajratwala, B.R. Dawson, J.E. |
| description | The kinetics of indomethacin degradation were followed in alkaline aqueous solutions at various temperatures between 20.1 and 40.7°. The apparent first‐order rate constants were evaluated from log absorbance versus time plots at λmax 318 nm. The primary salt effect was positive. The rate constant‐hydroxide‐ion concentration profile was linear with a positive slope, suggesting the following rate law. kobs= k1 [OH−]. The experimental data fit the proposed reaction of degradation, I− + OH− k1 →k1products, where I− = mono‐dissociated indomethacin species. Activationenergies and other related parameters were calculated from Arrhenius‐type plots. |
| doi_str_mv | 10.1002/jps.2600660106 |
| format | Article |
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The apparent first‐order rate constants were evaluated from log absorbance versus time plots at λmax 318 nm. The primary salt effect was positive. The rate constant‐hydroxide‐ion concentration profile was linear with a positive slope, suggesting the following rate law. kobs= k1 [OH−]. The experimental data fit the proposed reaction of degradation, I− + OH− k1 →k1products, where I− = mono‐dissociated indomethacin species. 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Pharm. Sci</addtitle><description>The kinetics of indomethacin degradation were followed in alkaline aqueous solutions at various temperatures between 20.1 and 40.7°. The apparent first‐order rate constants were evaluated from log absorbance versus time plots at λmax 318 nm. The primary salt effect was positive. The rate constant‐hydroxide‐ion concentration profile was linear with a positive slope, suggesting the following rate law. kobs= k1 [OH−]. The experimental data fit the proposed reaction of degradation, I− + OH− k1 →k1products, where I− = mono‐dissociated indomethacin species. Activationenergies and other related parameters were calculated from Arrhenius‐type plots.</description><subject>Alkalies</subject><subject>Anti-inflammatory agents-indomethacin</subject><subject>Anti‐inflammatory agents‐indomethacin, degradation in alkaline aqueous solutions, various temperatures, kinetics</subject><subject>degradation in alkaline aqueous solutions</subject><subject>Degradation-indomethacin in alkaline aqueous solutions</subject><subject>Degradation—indomethacin in alkaline aqueous solutions, various temperatures, kinetics, effect of ionic strength</subject><subject>Drug Stability</subject><subject>effect of ionic strength</subject><subject>Hot Temperature</subject><subject>Hydroxides</subject><subject>Indomethacin</subject><subject>Indomethacin-degradation in alkaline aqueous solutions</subject><subject>Indomethacin—degradation in alkaline aqueous solutions, various temperatures, kinetics, effect of ionic strength</subject><subject>Kinetics</subject><subject>Kinetics-degradation of indomethacin inalkaline aqueous solutions</subject><subject>Kinetics—degradation of indomethacin inalkaline aqueous solutions, various temperatures, effect of ionic strength</subject><subject>Osmolar Concentration</subject><subject>various temperatures</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEUha2qlAbaLSsWs2I34c74FWcX8WoAtZFKle4s174DTiYzwZ7w-Pd1NAjUBerKts53juSPkIMChgVAebxYx2EpAISAAsQHMih4CXl6yI9kkIAyp5ypz2QvxgUkDDjfJZ9GlEo6GpDxlW-w8zZmbZVNG9eusLsz1jfZKd4G40zn2yabjrNZwIiNxS03qZem9l_ITmXqiF9fzn3y6_zs5uRbfv3jYnoyuc4tZYXIuZUGrZOSOg5WAVQlU4pxC8aCwkoxZlS6sIJVKRbcCScAlSsLpyQTdJ8c9bvr0N5vMHZ65aPFujYNtpuoR1QqLoVK4LAHbWhjDFjpdfArE551AXrrSidX-s1VKhy-LG_-rNC94r2cFKs-fvQ1Pv9nTF_Ofv4znfddHzt8eu2asNRCUsn1_PuF_j2_mStFZ3qW-FHPYzL54DHoaP3Wt_MBbadd69_7xV97apVd</recordid><startdate>197701</startdate><enddate>197701</enddate><creator>Hajratwala, B.R.</creator><creator>Dawson, J.E.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197701</creationdate><title>Kinetics of Indomethacin Degradation I: Presence of Alkali</title><author>Hajratwala, B.R. ; Dawson, J.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3416-5c7aecd773d50c900f249945c0ac09ef944a909e414fc9065d6d60e9d21d97463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Alkalies</topic><topic>Anti-inflammatory agents-indomethacin</topic><topic>Anti‐inflammatory agents‐indomethacin, degradation in alkaline aqueous solutions, various temperatures, kinetics</topic><topic>degradation in alkaline aqueous solutions</topic><topic>Degradation-indomethacin in alkaline aqueous solutions</topic><topic>Degradation—indomethacin in alkaline aqueous solutions, various temperatures, kinetics, effect of ionic strength</topic><topic>Drug Stability</topic><topic>effect of ionic strength</topic><topic>Hot Temperature</topic><topic>Hydroxides</topic><topic>Indomethacin</topic><topic>Indomethacin-degradation in alkaline aqueous solutions</topic><topic>Indomethacin—degradation in alkaline aqueous solutions, various temperatures, kinetics, effect of ionic strength</topic><topic>Kinetics</topic><topic>Kinetics-degradation of indomethacin inalkaline aqueous solutions</topic><topic>Kinetics—degradation of indomethacin inalkaline aqueous solutions, various temperatures, effect of ionic strength</topic><topic>Osmolar Concentration</topic><topic>various temperatures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hajratwala, B.R.</creatorcontrib><creatorcontrib>Dawson, J.E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hajratwala, B.R.</au><au>Dawson, J.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetics of Indomethacin Degradation I: Presence of Alkali</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1977-01</date><risdate>1977</risdate><volume>66</volume><issue>1</issue><spage>27</spage><epage>29</epage><pages>27-29</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The kinetics of indomethacin degradation were followed in alkaline aqueous solutions at various temperatures between 20.1 and 40.7°. The apparent first‐order rate constants were evaluated from log absorbance versus time plots at λmax 318 nm. The primary salt effect was positive. The rate constant‐hydroxide‐ion concentration profile was linear with a positive slope, suggesting the following rate law. kobs= k1 [OH−]. The experimental data fit the proposed reaction of degradation, I− + OH− k1 →k1products, where I− = mono‐dissociated indomethacin species. Activationenergies and other related parameters were calculated from Arrhenius‐type plots.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>833738</pmid><doi>10.1002/jps.2600660106</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1977-01, Vol.66 (1), p.27-29 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Alkalies Anti-inflammatory agents-indomethacin Anti‐inflammatory agents‐indomethacin, degradation in alkaline aqueous solutions, various temperatures, kinetics degradation in alkaline aqueous solutions Degradation-indomethacin in alkaline aqueous solutions Degradation—indomethacin in alkaline aqueous solutions, various temperatures, kinetics, effect of ionic strength Drug Stability effect of ionic strength Hot Temperature Hydroxides Indomethacin Indomethacin-degradation in alkaline aqueous solutions Indomethacin—degradation in alkaline aqueous solutions, various temperatures, kinetics, effect of ionic strength Kinetics Kinetics-degradation of indomethacin inalkaline aqueous solutions Kinetics—degradation of indomethacin inalkaline aqueous solutions, various temperatures, effect of ionic strength Osmolar Concentration various temperatures |
| title | Kinetics of Indomethacin Degradation I: Presence of Alkali |
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