Xenon Inhalation as an Adjunct to Computerized Tomography of the Brain: Preliminary Study
The purpose of this study is to determine whether computerized tomography can distinguish between brain tissue and brain tissue containing dissolved xenon at physiologic concentrations. Xenon is an inert gas of high atomic number (54), and is highly soluble in tissue, particularly in fat. Its presen...
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| Veröffentlicht in: | Investigative radiology 1977-01, Vol.12 (1), p.15-18 |
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| container_title | Investigative radiology |
| container_volume | 12 |
| creator | WINKLER, STEFAN S SACKETT, JOSEPH F HOLDEN, JAMES E FLEMMING, DAVID C ALEXANDER, S CRAIGHEAD MADSEN, MARK KIMMEL, ROGER I |
| description | The purpose of this study is to determine whether computerized tomography can distinguish between brain tissue and brain tissue containing dissolved xenon at physiologic concentrations. Xenon is an inert gas of high atomic number (54), and is highly soluble in tissue, particularly in fat. Its presence in the brain after inhalation is manifested by well known anesthetic effects. Phantom studies using xenon in equilibrium at atmospheric pressure with water, corn oil, and milk samples of varying known fat content, demonstrate that xenon is detectable in all cases with a steep linear increase in change of attenuation factor (EMI number) with increasing fat content. In the rhesus monkey xenon is readily detectable at 20% inhaled gas concentration, with linear increase of attenuation factor with increasing concentration. The possible application of our findings to the study of brain pathophysiology is discussed. Since xenon is a potent although safe anesthestic, caution in clinical application is advised. |
| doi_str_mv | 10.1097/00004424-197701000-00005 |
| format | Article |
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Xenon is an inert gas of high atomic number (54), and is highly soluble in tissue, particularly in fat. Its presence in the brain after inhalation is manifested by well known anesthetic effects. Phantom studies using xenon in equilibrium at atmospheric pressure with water, corn oil, and milk samples of varying known fat content, demonstrate that xenon is detectable in all cases with a steep linear increase in change of attenuation factor (EMI number) with increasing fat content. In the rhesus monkey xenon is readily detectable at 20% inhaled gas concentration, with linear increase of attenuation factor with increasing concentration. The possible application of our findings to the study of brain pathophysiology is discussed. 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Xenon is an inert gas of high atomic number (54), and is highly soluble in tissue, particularly in fat. Its presence in the brain after inhalation is manifested by well known anesthetic effects. Phantom studies using xenon in equilibrium at atmospheric pressure with water, corn oil, and milk samples of varying known fat content, demonstrate that xenon is detectable in all cases with a steep linear increase in change of attenuation factor (EMI number) with increasing fat content. In the rhesus monkey xenon is readily detectable at 20% inhaled gas concentration, with linear increase of attenuation factor with increasing concentration. The possible application of our findings to the study of brain pathophysiology is discussed. Since xenon is a potent although safe anesthestic, caution in clinical application is advised.</description><subject>Animals</subject><subject>Cerebrovascular Disorders - diagnostic imaging</subject><subject>Contrast Media - administration & dosage</subject><subject>Haplorhini</subject><subject>Models, Structural</subject><subject>Respiration</subject><subject>Tomography, X-Ray Computed</subject><subject>Xenon - administration & dosage</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq2q0C5L_0EPPnELHX_FNrdlRelKSCABUnuyvI7ThCbxYidCy6-vt0v3xlw8nnln7HkGIUzgnICW3yAb55QXREsJJN-KXUh8QDMiWFkAJfARzQAoFFrr8jM6SekpK6gE9gkdc6CM0Rn69dMPYcCrobGdHdvs2oTtgBfV0zS4EY8BL0O_mUYf21df4YfQh9_RbpotDjUeG48vo22HC3wXfdf27WDjFt-PU7U9RUe17ZL_8nbO0eP3q4flj-Lm9nq1XNwUjgkuCktFrVjplGOaSSd4ySspSk3XldDgvBPaClJRkDV4DQKqWuXZiBJCcKoYm6Ozfd9NDM-TT6Pp2-R819nBhykZxaRUSkEWqr3QxZBS9LXZxLbP_zUEzA6q-Q_VHKD-C4lc-vXtjWnd--pQuKeY03yffgldBpX-dNOLj6bxthsb896q2F-qWX_m</recordid><startdate>197701</startdate><enddate>197701</enddate><creator>WINKLER, STEFAN S</creator><creator>SACKETT, JOSEPH F</creator><creator>HOLDEN, JAMES E</creator><creator>FLEMMING, DAVID C</creator><creator>ALEXANDER, S CRAIGHEAD</creator><creator>MADSEN, MARK</creator><creator>KIMMEL, ROGER I</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197701</creationdate><title>Xenon Inhalation as an Adjunct to Computerized Tomography of the Brain: Preliminary Study</title><author>WINKLER, STEFAN S ; SACKETT, JOSEPH F ; HOLDEN, JAMES E ; FLEMMING, DAVID C ; ALEXANDER, S CRAIGHEAD ; MADSEN, MARK ; KIMMEL, ROGER I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3545-a25f836c8c3937c5464d75692bd590cec59a51d207f0e9050df82101855542833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Cerebrovascular Disorders - diagnostic imaging</topic><topic>Contrast Media - administration & dosage</topic><topic>Haplorhini</topic><topic>Models, Structural</topic><topic>Respiration</topic><topic>Tomography, X-Ray Computed</topic><topic>Xenon - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WINKLER, STEFAN S</creatorcontrib><creatorcontrib>SACKETT, JOSEPH F</creatorcontrib><creatorcontrib>HOLDEN, JAMES E</creatorcontrib><creatorcontrib>FLEMMING, DAVID C</creatorcontrib><creatorcontrib>ALEXANDER, S CRAIGHEAD</creatorcontrib><creatorcontrib>MADSEN, MARK</creatorcontrib><creatorcontrib>KIMMEL, ROGER I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WINKLER, STEFAN S</au><au>SACKETT, JOSEPH F</au><au>HOLDEN, JAMES E</au><au>FLEMMING, DAVID C</au><au>ALEXANDER, S CRAIGHEAD</au><au>MADSEN, MARK</au><au>KIMMEL, ROGER I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xenon Inhalation as an Adjunct to Computerized Tomography of the Brain: Preliminary Study</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>1977-01</date><risdate>1977</risdate><volume>12</volume><issue>1</issue><spage>15</spage><epage>18</epage><pages>15-18</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>The purpose of this study is to determine whether computerized tomography can distinguish between brain tissue and brain tissue containing dissolved xenon at physiologic concentrations. 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Since xenon is a potent although safe anesthestic, caution in clinical application is advised.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>402332</pmid><doi>10.1097/00004424-197701000-00005</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0020-9996 |
| ispartof | Investigative radiology, 1977-01, Vol.12 (1), p.15-18 |
| issn | 0020-9996 1536-0210 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Cerebrovascular Disorders - diagnostic imaging Contrast Media - administration & dosage Haplorhini Models, Structural Respiration Tomography, X-Ray Computed Xenon - administration & dosage |
| title | Xenon Inhalation as an Adjunct to Computerized Tomography of the Brain: Preliminary Study |
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