Immunoglobulins in the serum and nasal secretions of lambs following vaccination and aerosol challenge with parainfluenza 3 virus
Serial changes in the concentrations of IgM, IgG and IgA were compared in specific pathogen free (SPF) Jambs which had been vaccinated with live or inactivated parainfluenza 3 virus (PI 3) by either intramuscular (IM) or intranasal (IN) routes followed by aerosol challenge with PI 3. In the serum, a...
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| Veröffentlicht in: | Research in veterinary science 1976-11, Vol.21 (3), p.341-348 |
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| container_issue | 3 |
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| container_title | Research in veterinary science |
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| creator | Smith, W.D. Dawson, A.McL Wells, P.W. Burrells, C. |
| description | Serial changes in the concentrations of IgM, IgG and IgA were compared in specific pathogen free (SPF) Jambs which had been vaccinated with live or inactivated parainfluenza 3 virus (PI 3) by either intramuscular (IM) or intranasal (IN) routes followed by aerosol challenge with PI 3. In the serum, an increase in IgM was associated with the primary antibody response to the aerosol challenge, whereas increased IgG was associated with the secondary antibody response. No changes in immunoglobulin concentrations were observed in the nasal secretions of lambs administered live or inactivated virus IM or IN without adjuvant. Marked increases in IgG were found in the serum and nasal secretions of lambs vaccinated IM with inactivated virus in Freund’s complete adjuvant (FCA) and fractionation by gel filtration confirmed that the antibody was associated with IgG in both these fluids. |
| doi_str_mv | 10.1016/S0034-5288(18)33348-4 |
| format | Article |
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In the serum, an increase in IgM was associated with the primary antibody response to the aerosol challenge, whereas increased IgG was associated with the secondary antibody response. No changes in immunoglobulin concentrations were observed in the nasal secretions of lambs administered live or inactivated virus IM or IN without adjuvant. Marked increases in IgG were found in the serum and nasal secretions of lambs vaccinated IM with inactivated virus in Freund’s complete adjuvant (FCA) and fractionation by gel filtration confirmed that the antibody was associated with IgG in both these fluids.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/S0034-5288(18)33348-4</identifier><identifier>PMID: 193171</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Administration, Intranasal ; Aerosols ; Animals ; Antibody Formation ; Immunoglobulin A - analysis ; Immunoglobulin G - analysis ; Immunoglobulin M - analysis ; Immunoglobulins - analysis ; Injections, Intramuscular ; Nasal Mucosa - immunology ; Nasal Mucosa - secretion ; Parainfluenza Virus 3, Human - immunology ; Respirovirus - immunology ; Sheep - immunology ; Vaccination - veterinary ; Viral Vaccines - administration & dosage</subject><ispartof>Research in veterinary science, 1976-11, Vol.21 (3), p.341-348</ispartof><rights>1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-5f958529135aff241ccf00784efcffc8d91e2acdfa68118dd28a4a696f9c72e73</citedby><cites>FETCH-LOGICAL-c359t-5f958529135aff241ccf00784efcffc8d91e2acdfa68118dd28a4a696f9c72e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0034-5288(18)33348-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/193171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, W.D.</creatorcontrib><creatorcontrib>Dawson, A.McL</creatorcontrib><creatorcontrib>Wells, P.W.</creatorcontrib><creatorcontrib>Burrells, C.</creatorcontrib><title>Immunoglobulins in the serum and nasal secretions of lambs following vaccination and aerosol challenge with parainfluenza 3 virus</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>Serial changes in the concentrations of IgM, IgG and IgA were compared in specific pathogen free (SPF) Jambs which had been vaccinated with live or inactivated parainfluenza 3 virus (PI 3) by either intramuscular (IM) or intranasal (IN) routes followed by aerosol challenge with PI 3. In the serum, an increase in IgM was associated with the primary antibody response to the aerosol challenge, whereas increased IgG was associated with the secondary antibody response. No changes in immunoglobulin concentrations were observed in the nasal secretions of lambs administered live or inactivated virus IM or IN without adjuvant. Marked increases in IgG were found in the serum and nasal secretions of lambs vaccinated IM with inactivated virus in Freund’s complete adjuvant (FCA) and fractionation by gel filtration confirmed that the antibody was associated with IgG in both these fluids.</description><subject>Administration, Intranasal</subject><subject>Aerosols</subject><subject>Animals</subject><subject>Antibody Formation</subject><subject>Immunoglobulin A - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>Immunoglobulins - analysis</subject><subject>Injections, Intramuscular</subject><subject>Nasal Mucosa - immunology</subject><subject>Nasal Mucosa - secretion</subject><subject>Parainfluenza Virus 3, Human - immunology</subject><subject>Respirovirus - immunology</subject><subject>Sheep - immunology</subject><subject>Vaccination - veterinary</subject><subject>Viral Vaccines - administration & dosage</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v1DAQxS3E17bwH4DkE4JDwBM7iXOqUMVHpUocgLM164x3jRx7sZOtyo3_nOxuRY89jUbvvRm9H2OvQbwHAe2H70JIVTW11m9Bv5NSKl2pR2wFjayrum3hMVv9tzxnZ6X8EkIogO4Zewq9hA5W7O_VOM4xbUJaz8HHwn3k05Z4oTyPHOPAIxYMy24zTT4tjuR4wHFduEshpBsfN3yP1vqIB_2YQcqppMDtFkOguCF-46ct32FGH12YKf5BLvne57m8YE8chkIv7-Y5-_n504_Lr9X1ty9Xlx-vKyubfqoa1ze6qXuQDTpXK7DWCdFpRc46Z_XQA9VoB4etBtDDUGtU2Pat621XUyfP2ZvT3V1Ov2cqkxl9sRQCRkpzMVp2HSilF2NzMtqlRMnkzC77EfOtAWEO5M2RvDlgNaDNkbxRS-7V3YN5PdJwnzqiXuSLk0xLyb2nbIr1FC0NPpOdzJD8Aw_-AQJOlko</recordid><startdate>197611</startdate><enddate>197611</enddate><creator>Smith, W.D.</creator><creator>Dawson, A.McL</creator><creator>Wells, P.W.</creator><creator>Burrells, C.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197611</creationdate><title>Immunoglobulins in the serum and nasal secretions of lambs following vaccination and aerosol challenge with parainfluenza 3 virus</title><author>Smith, W.D. ; Dawson, A.McL ; Wells, P.W. ; Burrells, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-5f958529135aff241ccf00784efcffc8d91e2acdfa68118dd28a4a696f9c72e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Administration, Intranasal</topic><topic>Aerosols</topic><topic>Animals</topic><topic>Antibody Formation</topic><topic>Immunoglobulin A - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>Immunoglobulins - analysis</topic><topic>Injections, Intramuscular</topic><topic>Nasal Mucosa - immunology</topic><topic>Nasal Mucosa - secretion</topic><topic>Parainfluenza Virus 3, Human - immunology</topic><topic>Respirovirus - immunology</topic><topic>Sheep - immunology</topic><topic>Vaccination - veterinary</topic><topic>Viral Vaccines - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, W.D.</creatorcontrib><creatorcontrib>Dawson, A.McL</creatorcontrib><creatorcontrib>Wells, P.W.</creatorcontrib><creatorcontrib>Burrells, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, W.D.</au><au>Dawson, A.McL</au><au>Wells, P.W.</au><au>Burrells, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulins in the serum and nasal secretions of lambs following vaccination and aerosol challenge with parainfluenza 3 virus</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>1976-11</date><risdate>1976</risdate><volume>21</volume><issue>3</issue><spage>341</spage><epage>348</epage><pages>341-348</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>Serial changes in the concentrations of IgM, IgG and IgA were compared in specific pathogen free (SPF) Jambs which had been vaccinated with live or inactivated parainfluenza 3 virus (PI 3) by either intramuscular (IM) or intranasal (IN) routes followed by aerosol challenge with PI 3. In the serum, an increase in IgM was associated with the primary antibody response to the aerosol challenge, whereas increased IgG was associated with the secondary antibody response. No changes in immunoglobulin concentrations were observed in the nasal secretions of lambs administered live or inactivated virus IM or IN without adjuvant. Marked increases in IgG were found in the serum and nasal secretions of lambs vaccinated IM with inactivated virus in Freund’s complete adjuvant (FCA) and fractionation by gel filtration confirmed that the antibody was associated with IgG in both these fluids.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>193171</pmid><doi>10.1016/S0034-5288(18)33348-4</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 1976-11, Vol.21 (3), p.341-348 |
| issn | 0034-5288 1532-2661 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Administration, Intranasal Aerosols Animals Antibody Formation Immunoglobulin A - analysis Immunoglobulin G - analysis Immunoglobulin M - analysis Immunoglobulins - analysis Injections, Intramuscular Nasal Mucosa - immunology Nasal Mucosa - secretion Parainfluenza Virus 3, Human - immunology Respirovirus - immunology Sheep - immunology Vaccination - veterinary Viral Vaccines - administration & dosage |
| title | Immunoglobulins in the serum and nasal secretions of lambs following vaccination and aerosol challenge with parainfluenza 3 virus |
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