Amniotic Fluid Tests for Fetal Maturity in Normal and Abnormal Pregnancies
The lecithin-sphingomyelin (L/S) ratio is acknowledged to be superior to most procedures for predicting fetal lung maturity in normal pregnancy. In complicated gestations, however, errors have been reported. This study involves 686 normal gestations and 389 pregnancies complicated by fetomaternal di...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1977-01, Vol.49 (1), p.20-24 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
| container_volume | 49 |
| creator | MORRISON, J. C. WHYBREW, W. D. BUCOVAZ, E. T. WISER, W. L. FISH, S. A. |
| description | The lecithin-sphingomyelin (L/S) ratio is acknowledged to be superior to most procedures for predicting fetal lung maturity in normal pregnancy. In complicated gestations, however, errors have been reported. This study involves 686 normal gestations and 389 pregnancies complicated by fetomaternal diseases. The L/S ratio, creatinine level, and percent of fat-staining cells were measured in samples of amniotic fluid from these patients. The results showed good correlation of all three tests with fetal maturity as measured by weight, Dubowitz criteria, and incidence of respiratory distress syndrome in the normal patients. In the complicated pregnancies, however, the creatinine was unacceptable in up to 30% of the cases. The L/S ratio likewise decreased in accuracy for all parameters of fetal maturity measured. The Nile blue staining of the fetal cells appeared to be the most consistent technic in these cases. A fetal maturity battery comprised of these three assays and other methods of assessing fetal health is advocated in pregnancies complicated by certain disease states. |
| format | Article |
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C. ; WHYBREW, W. D. ; BUCOVAZ, E. T. ; WISER, W. L. ; FISH, S. A.</creator><creatorcontrib>MORRISON, J. C. ; WHYBREW, W. D. ; BUCOVAZ, E. T. ; WISER, W. L. ; FISH, S. A.</creatorcontrib><description>The lecithin-sphingomyelin (L/S) ratio is acknowledged to be superior to most procedures for predicting fetal lung maturity in normal pregnancy. In complicated gestations, however, errors have been reported. This study involves 686 normal gestations and 389 pregnancies complicated by fetomaternal diseases. The L/S ratio, creatinine level, and percent of fat-staining cells were measured in samples of amniotic fluid from these patients. The results showed good correlation of all three tests with fetal maturity as measured by weight, Dubowitz criteria, and incidence of respiratory distress syndrome in the normal patients. In the complicated pregnancies, however, the creatinine was unacceptable in up to 30% of the cases. The L/S ratio likewise decreased in accuracy for all parameters of fetal maturity measured. The Nile blue staining of the fetal cells appeared to be the most consistent technic in these cases. A fetal maturity battery comprised of these three assays and other methods of assessing fetal health is advocated in pregnancies complicated by certain disease states.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 63926</identifier><language>eng</language><publisher>United States: The American College of Obstetricians and Gynecologists</publisher><subject>Amniocentesis ; Amniotic Fluid - metabolism ; Birth Weight ; Creatinine - metabolism ; Female ; Fetus - physiology ; Humans ; Phosphatidylcholines - metabolism ; Pregnancy ; Pregnancy Complications - metabolism ; Sphingomyelins - metabolism ; Staining and Labeling</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1977-01, Vol.49 (1), p.20-24</ispartof><rights>1977 The American College of Obstetricians and Gynecologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/63926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MORRISON, J. C.</creatorcontrib><creatorcontrib>WHYBREW, W. D.</creatorcontrib><creatorcontrib>BUCOVAZ, E. T.</creatorcontrib><creatorcontrib>WISER, W. L.</creatorcontrib><creatorcontrib>FISH, S. A.</creatorcontrib><title>Amniotic Fluid Tests for Fetal Maturity in Normal and Abnormal Pregnancies</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>The lecithin-sphingomyelin (L/S) ratio is acknowledged to be superior to most procedures for predicting fetal lung maturity in normal pregnancy. In complicated gestations, however, errors have been reported. This study involves 686 normal gestations and 389 pregnancies complicated by fetomaternal diseases. The L/S ratio, creatinine level, and percent of fat-staining cells were measured in samples of amniotic fluid from these patients. The results showed good correlation of all three tests with fetal maturity as measured by weight, Dubowitz criteria, and incidence of respiratory distress syndrome in the normal patients. In the complicated pregnancies, however, the creatinine was unacceptable in up to 30% of the cases. The L/S ratio likewise decreased in accuracy for all parameters of fetal maturity measured. The Nile blue staining of the fetal cells appeared to be the most consistent technic in these cases. A fetal maturity battery comprised of these three assays and other methods of assessing fetal health is advocated in pregnancies complicated by certain disease states.</description><subject>Amniocentesis</subject><subject>Amniotic Fluid - metabolism</subject><subject>Birth Weight</subject><subject>Creatinine - metabolism</subject><subject>Female</subject><subject>Fetus - physiology</subject><subject>Humans</subject><subject>Phosphatidylcholines - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - metabolism</subject><subject>Sphingomyelins - metabolism</subject><subject>Staining and Labeling</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotUMlOwzAQtRAVlMIXcPGJWyRvseNjVVEoKsuhSNwix5lQg5MU21HVvyfQnuZtGs28MzSlheIZ4_zjHE0JYTpThRCX6CrGL0IIlZpfoInkmskpepq3neuTs3jpB1fjDcQUcdMHvIRkPH42aQguHbDr8Esf2lEyXY3nVXckbwE-O9NZB_EaTRrjI9yc5gy9L-83i8ds_fqwWszX2Y4JLbJKVVBQxbRlpJYCKqaopKQmTDZAoW4ESEFtJSqrc5WrRlmRqxq0yJsRWD5Dd8e9u9D_DOO9ZeuiBe9NB_0Qy4KrnGklx-DtKThULdTlLrjWhEP5__roiqO7732CEL_9sIdQbsH4tC3HoohkOcmoVorQkWV_kuC_kL9k0w</recordid><startdate>197701</startdate><enddate>197701</enddate><creator>MORRISON, J. C.</creator><creator>WHYBREW, W. D.</creator><creator>BUCOVAZ, E. T.</creator><creator>WISER, W. L.</creator><creator>FISH, S. A.</creator><general>The American College of Obstetricians and Gynecologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197701</creationdate><title>Amniotic Fluid Tests for Fetal Maturity in Normal and Abnormal Pregnancies</title><author>MORRISON, J. C. ; WHYBREW, W. D. ; BUCOVAZ, E. T. ; WISER, W. L. ; FISH, S. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2494-b7be81729c20d64eb271610d026fe1edf4e641cb4bc95757f7c457de945f457c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Amniocentesis</topic><topic>Amniotic Fluid - metabolism</topic><topic>Birth Weight</topic><topic>Creatinine - metabolism</topic><topic>Female</topic><topic>Fetus - physiology</topic><topic>Humans</topic><topic>Phosphatidylcholines - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - metabolism</topic><topic>Sphingomyelins - metabolism</topic><topic>Staining and Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MORRISON, J. C.</creatorcontrib><creatorcontrib>WHYBREW, W. D.</creatorcontrib><creatorcontrib>BUCOVAZ, E. T.</creatorcontrib><creatorcontrib>WISER, W. L.</creatorcontrib><creatorcontrib>FISH, S. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORRISON, J. C.</au><au>WHYBREW, W. D.</au><au>BUCOVAZ, E. T.</au><au>WISER, W. L.</au><au>FISH, S. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amniotic Fluid Tests for Fetal Maturity in Normal and Abnormal Pregnancies</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1977-01</date><risdate>1977</risdate><volume>49</volume><issue>1</issue><spage>20</spage><epage>24</epage><pages>20-24</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><abstract>The lecithin-sphingomyelin (L/S) ratio is acknowledged to be superior to most procedures for predicting fetal lung maturity in normal pregnancy. In complicated gestations, however, errors have been reported. This study involves 686 normal gestations and 389 pregnancies complicated by fetomaternal diseases. The L/S ratio, creatinine level, and percent of fat-staining cells were measured in samples of amniotic fluid from these patients. The results showed good correlation of all three tests with fetal maturity as measured by weight, Dubowitz criteria, and incidence of respiratory distress syndrome in the normal patients. In the complicated pregnancies, however, the creatinine was unacceptable in up to 30% of the cases. The L/S ratio likewise decreased in accuracy for all parameters of fetal maturity measured. The Nile blue staining of the fetal cells appeared to be the most consistent technic in these cases. A fetal maturity battery comprised of these three assays and other methods of assessing fetal health is advocated in pregnancies complicated by certain disease states.</abstract><cop>United States</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>63926</pmid><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1977-01, Vol.49 (1), p.20-24 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Amniocentesis Amniotic Fluid - metabolism Birth Weight Creatinine - metabolism Female Fetus - physiology Humans Phosphatidylcholines - metabolism Pregnancy Pregnancy Complications - metabolism Sphingomyelins - metabolism Staining and Labeling |
| title | Amniotic Fluid Tests for Fetal Maturity in Normal and Abnormal Pregnancies |
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